A gene delivery system containing nuclear localization signal: Increased nucleus import and transfection efficiency with the assistance of RanGAP1.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Acta Biomaterialia

• Publication date

  2017-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.actbio.2016.11.004PMID 27816620
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Serum starvation and thymidine double blocking achieved efficient cell cycle synchronization and altered the expression of p27, p53, bcl-2 in canine breast cancer cells.

  2016cited by this paper
• Gene therapy as a potential tool for treating neuroblastoma—a focused review

  2016cited by this paper
• Synthesis and characterization of a PAMAM-OH derivative containing an acid-labile β-thiopropionate bond for gene delivery.

  2016cited by this paper
• Incorporation of a Nuclear Localization Signal in pH Responsive LAH4-L1 Peptide Enhances Transfection and Nuclear Uptake of Plasmid DNA.

  2016cited by this paper
• Non-viral gene therapy: Gains and challenges of non-invasive administration methods.

  2016cited by this paper
• The Synthesis of Cyclic Poly(ethylene imine) and Exact Linear Analogues: An Evaluation of Gene Delivery Comparing Polymer Architectures.

  2015cited by this paper
• Dual targeting of retinoid X receptor and histone deacetylase with DW22 as a novel antitumor approach

  2015cited by this paper
• Targeted Delivery of Nucleic Acid Therapeutics via Nonviral Vectors

  2015cited by this paper
• Nuclear localization signals for four distinct karyopherin-β nuclear import systems.

  2015cited by this paper
• Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner

  2015cited by this paper
• Ran GTPase in nuclear envelope formation and cancer metastasis.

  2014cited by this paper
• A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway.

  2014cited by this paper
• Interplay between nuclear transport and ubiquitin/SUMO modifications in the regulation of cancer-related proteins.

  2014cited by this paper
• Non-viral vectors for gene-based therapy

  2014cited by this paper
• In vitro inhibition of the replication of classical swine fever virus by porcine Mx1 protein.

  2014cited by this paper
• Interpretation of protein quantitation using the Bradford assay: comparison with two calculation models.

  2013cited by this paper
• Nuclear location signal peptide–modified poly (ethyleneimine)/DNA complexes: An efficient gene delivery vector in vitro and in vivo

  2013cited by this paper
• The molecular architecture of the plant nuclear pore complex.

  2013cited by this paper
• Non-viral gene delivery methods.

  2013cited by this paper
• Intracellular pathways and nuclear localization signal peptide-mediated gene transfection by cationic polymeric nanovectors.

  2012cited by this paper
• Functional architecture of the nuclear pore complex.

  2012cited by this paper
• Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions

  2012cited by this paper
• Understanding nonviral nucleic acid delivery with quantum dot-FRET nanosensors.

  2012cited by this paper
• Dextran-protamine-solid lipid nanoparticles as a non-viral vector for gene therapy: in vitro characterization and in vivo transfection after intravenous administration to mice.

  2012cited by this paper
• The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect.

  2011cited by this paper
• Endoprotease-mediated intracellular protein delivery using nanocapsules.

  2011cited by this paper
• Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles.

  2010cited by this paper
• Short biodegradable polyamines for gene delivery and transfection of brain capillary endothelial cells.

  2010cited by this paper
• Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity.

  2008cited by this paper
• Fluorescent resonance energy transfer: A tool for probing molecular cell-biomaterial interactions in three dimensions.

  2007cited by this paper
• Nuclear targeting of non-viral gene carriers using psoralen-nuclear localization signal (NLS) conjugates.

  2007cited by this paper
• Classical Nuclear Localization Signals: Definition, Function, and Interaction with Importin α*

  2007cited by this paper
• Structural biology of nucleocytoplasmic transport.

  2007cited by this paper
• Uptake characteristics of liposomes by rat alveolar macrophages: influence of particle size and surface mannose modification

  2007cited by this paper
• Nuclear Localization Signal Receptor Affinity Correlates with in Vivo Localization in Saccharomyces cerevisiae*

  2006cited by this paper
• China approves first gene therapy

  2004cited by this paper
• Improvement of exogenous DNA nuclear importation by nuclear localization signal‐bearing vectors: a promising way for non‐viral gene therapy?

  2003cited by this paper
• The nuclear pore complex: nucleocytoplasmic transport and beyond

  2003cited by this paper
• Non-viral gene therapy: polycation-mediated DNA delivery

  2003cited by this paper
• Barriers to nonviral gene delivery.

  2003cited by this paper
• RanGAP mediates GTP hydrolysis without an arginine finger

  2002cited by this paper
• Dissection of a Nuclear Localization Signal*

  2001cited by this paper
• The nuclear pore complex: mediator of translocation between nucleus and cytoplasm.

  2000cited by this paper
• Synthetic DNA delivery systems

  2000cited by this paper
• Mitosis enhances transgene expression of plasmid delivered by cationic liposomes.

  1999cited by this paper
• Identification of different roles for RanGDP and RanGTP in nuclear protein import.

  1996cited by this paper
• New amphipatic polymer-lipid conjugates forming long-circulating reticuloendothelial system-evading liposomes.

  1994cited by this paper
• The basic science of gene therapy.

  1993cited by this paper

• Recent Advances in the Molecular Engineering of Synthetic Polypeptides: Design, Synthesis, Functionality, and Biological Applications

  2025cites this paper
• Polymeric nanocarriers for therapeutic gene delivery

  2025cites this paper
• Increased stable integration efficiency in CHO cells through enhanced nuclear localization of Bxb1 serine integrase

  2024cites this paper
• Enhancing non-viral DNA delivery systems: Recent advances in improving efficiency and target specificity.

  2024cites this paper
• Nanoassemblies designed for efficient nuclear targeting.

  2024cites this paper
• Nuclear localization signal-tagged systems: relevant nuclear import principles in the context of current therapeutic design.

  2023cites this paper
• Nanobiomaterial vectors for improving gene editing and gene therapy

  2023cites this paper
• Targeting necroptosis as an alternative strategy in tumor treatment: From drugs to nanoparticles.

  2022cites this paper
• Design and application of DNA nanostructures for organelle-targeted delivery of anticancer drugs

  2022cites this paper
• Advances in the Development of Biodegradable Polymeric Materials for Biomedical Applications

  2022cites this paper
• Guanidinylated Cyclic Synthetic Polypeptides Can Effectively Deliver siRNA by Mimicking the Biofunctions of Both Cell-Penetrating Peptides and Nuclear Localization Signal Peptides.

  2021cites this paper
• Recent advances in targeted nanotherapeutic approaches for breast cancer management.

  2021cites this paper
• Strategies for Improving the Efficiency of Nanomaterials

  2021cites this paper
• Amino acids functionalized dendrimers with nucleus accumulation for efficient gene delivery.

  2021cites this paper
• Multifunctional Peptide-Conjugated Nanocarriers for Pulp Regeneration in a Full-Length Human Tooth Root.

  2021cites this paper
• A core-shell nanoplatform as a nonviral vector for targeted delivery of genes to the retina.

  2021cites this paper
• Application of nano-based systems for drug delivery and targeting: a review

  2020cites this paper
• Modulation of membrane properties by DNA in liposomes: A spectroscopic study.

  2020cites this paper
• Phospholipid-Coated Guanosine Diphosphate Auxiliary CaP Active Nanoparticles Can Systematically Improve the Efficiency of Gene Therapy for Cancer Disease.

  2020cites this paper
• Application of advances in endocytosis and membrane trafficking to drug delivery.

  2020cites this paper
• Tailoring Iron Oxide Nanoparticles for Efficient Cellular Internalization and Endosomal Escape

  2020cites this paper
• A progressively targeted gene delivery system with a pH triggered surface charge-switching ability to drive angiogenesis in vivo.

  2019cites this paper
• Multifunctional REDV-G-TAT-G-NLS-Cys peptide sequence conjugated gene carriers to enhance gene transfection efficiency in endothelial cells.

  2019cites this paper
• Multifunctional Gene Carriers Labeled by Perylene Diimide Derivative as Fluorescent Probe for Tracking Gene Delivery.

  2019cites this paper
• Biological barriers to cellular interventions

  2019cites this paper
• Bypassing Border Control: Nuclear Envelope Rupture in Disease.

  2018cites this paper
• Self-assembled CaP-based hybrid nanoparticles to enhance gene transfection efficiency in vitro and in vivo: beneficial utilization of PEGylated bisphosphate and nucleus locating signal.

  2018cites this paper
• Methodologies to investigate intracellular barriers for nucleic acid delivery in non-viral gene therapy

  2018cites this paper
• Multitargeting Peptide-Functionalized Star-Shaped Copolymers with Comblike Structure and a POSS-Core To Effectively Transfect Endothelial Cells.

  2018cites this paper
• Design of Polymeric Gene Carriers for Effective Intracellular Delivery.

  2018cites this paper
• 2-Aminoimidazole facilitates efficient gene delivery in a low molecular weight poly(amidoamine) dendrimer.

  2018cites this paper
• Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities.

  2018cites this paper
• Bioreducible, hydrolytically degradable and targeting polymers for gene delivery.

  2017cites this paper
• Strategies for the enhanced intracellular delivery of nanomaterials

  2017cites this paper
• Extra- and intra-cellular fate of nanocarriers under dynamic interactions with biology

  2017cites this paper
• Multifunctional Gene Carriers with Enhanced Specific Penetration and Nucleus Accumulation to Promote Neovascularization of HUVECs in Vivo.

  2017influential citation