Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Molecular and Cellular Endocrinology

• Publication date

  2013-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mce.2013.05.003PMID 23707792
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.

  2012cited by this paper
• GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1)

  2011cited by this paper
• FTY720 Normalizes Hyperglycemia by Stimulating β-Cell in Vivo Regeneration in db/db Mice through Regulation of Cyclin D3 and p57KIP2*

  2011cited by this paper
• Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects

  2011cited by this paper
• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

  2010cited by this paper
• Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating.

  2010cited by this paper
• Cyclin I-Cdk5 governs survival in post-mitotic cells.

  2010cited by this paper
• Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a

  2010cited by this paper
• Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

  2010cited by this paper
• Cyclin D2 Is Essential for the Compensatory β-Cell Hyperplastic Response to Insulin Resistance in Rodents

  2010cited by this paper
• Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

  2010cited by this paper
• An Immune Response Network Associated with Blood Lipid Levels

  2010cited by this paper
• Cyclin D2 protein stability is regulated in pancreatic beta-cells.

  2009cited by this paper
• Islet Specific Wnt Activation in Human Type II Diabetes

  2009cited by this paper
• The Retinoblastoma Protein and Its Homolog p130 Regulate the G1/S Transition in Pancreatic β-Cells

  2009cited by this paper
• A crucial role for adipose tissue p53 in the regulation of insulin resistance

  2009cited by this paper
• Survey of the Human Pancreatic β-Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human β-Cell Replication and Function In Vivo

  2009cited by this paper
• Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

  2009cited by this paper
• β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans

  2008cited by this paper
• Differential expression of cell cycle proteins during ageing of pancreatic islet cells

  2008cited by this paper
• CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

  2008cited by this paper
• Impaired islet turnover in human donor pancreata with aging.

  2008cited by this paper
• Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers.

  2007cited by this paper
• Cdk1 is sufficient to drive the mammalian cell cycle

  2007cited by this paper
• p16INK4a induces an age-dependent decline in islet regenerative potential

  2006cited by this paper
• The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation

  2006cited by this paper
• Molecular control of cell cycle progression in the pancreatic beta-cell.

  2006cited by this paper
• Molecular Control of Cell Cycle Progression in the Pancreatic β-Cell

  2006cited by this paper
• Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis.

  2006cited by this paper
• Intrinsic Regulators of Pancreatic β-Cell Proliferation

  2006cited by this paper
• Intrinsic regulators of pancreatic beta-cell proliferation.

  2006cited by this paper
• Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

  2005cited by this paper
• Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression

  2005cited by this paper
• Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c.

  2005cited by this paper
• Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth.

  2005cited by this paper
• Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth

  2005cited by this paper
• Ink4a/Arf expression is a biomarker of aging.

  2004cited by this paper
• Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1.

  2004cited by this paper
• Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.

  2004cited by this paper
• Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.

  2004cited by this paper
• Cellular sources of new pancreatic β cells and therapeutic implications for regenerative medicine

  2004cited by this paper
• Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

  2004cited by this paper
• β cell replication is the primary mechanism for maintaining postnatal β cell mass

  2004cited by this paper
• Cyclins That Don’t Cycle : Cyclin T/Cyclin-Dependent Kinase-9 Determines Cardiac Muscle Cell Size

  2003cited by this paper
• The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

  2003cited by this paper
• Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue Specificity

  2000cited by this paper
• Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction

  1999cited by this paper
• Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

  1999cited by this paper
• Expression of a novel isoform of cyclin I in human testis.

  1998cited by this paper
• Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

  1997cited by this paper
• Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame

  1997cited by this paper
• Cyclin I: a new cyclin encoded by a gene isolated from human brain.

  1995cited by this paper

• Combined bioinformatics and experimental validation identifies m1A-modified genes as potential diagnostic biomarkers in periodontitis and diabetes.

  2025cites this paper
• (Poly)phenols and diabetes: from effects to mechanisms by systematic multigenomic analysis.

  2024cites this paper
• Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes

  2024cites this paper
• Unveiling the link between arsenic toxicity and diabetes: an in silico exploration into the role of transcription factors

  2024cites this paper
• Insights into the structural and functional activities of forgotten Kinases: PCTAIREs CDKs

  2024cites this paper
• Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness

  2024cites this paper
• Network medicine based approach for identifying the type 2 diabetes, osteoarthritis and triple negative breast cancer interactome: Finding the hub of hub genes

  2024cites this paper
• Search for polymorphic variants of candidate genes contributing to individual radiosensitivity

  2023cites this paper
• Validating Fractalkine receptor as a target and identifying candidates for drug discovery against type 2 diabetes

  2023cites this paper
• A data integration approach unveils a transcriptional signature of type 2 diabetes progression in rat and human islets

  2023cites this paper
• Metabolic profiling of Apostichopus japonicus body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health

  2023cites this paper
• Circulating MiRNAs Are Associated With Low-grade Systemic Inflammation and Leptin Levels in Older Adults

  2023cites this paper
• Connecting islet-specific hub genes and pathways in type 2 diabetes mellitus through the bioinformatics lens

  2023cites this paper
• CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs

  2023cites this paper
• Retinal Transcriptome and Cellular Landscape in Relation to the Progression of Diabetic Retinopathy

  2022cites this paper
• T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased β-cell proliferation

  2022cites this paper
• Overview of Transcriptomic Research on Type 2 Diabetes: Challenges and Perspectives

  2022cites this paper
• Establishment and Verification of a Gene Signature for Diagnosing Type 2 Diabetics by WGCNA, LASSO Analysis, and In Vitro Experiments

  2022cites this paper
• A suggested shared aetiology of dementia - a colocalization study.

  2022cites this paper
• Novel Molecular Networks and Regulatory MicroRNAs in Type 2 Diabetes Mellitus: Multiomics Integration and Interactomics Study

  2022influential citation
• Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications

  2021cites this paper
• CCNI2 plays a promoting role in the progression of colorectal cancer

  2021cites this paper
• Overview of PCTK3/CDK18: A Cyclin-Dependent Kinase Involved in Specific Functions in Post-Mitotic Cells.

  2021cites this paper
• Redox Homeostasis in Pancreatic β-Cells: From Development to Failure

  2021cites this paper
• Cisplatin's potential for type 2 diabetes repositioning by inhibiting CDKN1A, FAS, and SESN1

  2021cites this paper
• MicroRNA-532-5p regulates oxidative stress and insulin secretion damage in high glucose-induced pancreatic β cells by downregulating the expression levels of CCND1

  2021cites this paper
• Gene–environment interaction identification via penalized robust divergence

  2021cites this paper
• Convolutional Neural Network–Based Automatic Classification of Colorectal and Prostate Tumor Biopsies Using Multispectral Imagery: System Development Study

  2021cites this paper
• A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study

  2020cites this paper
• DMSO_A_245165 1793..1801

  2020cites this paper
• 3 TRANSCRIPTOMIC ANALYSIS IN DIABETES 4

  2020cites this paper
• Identification of Hub Genes in Type 2 Diabetes Mellitus Using Bioinformatics Analysis

  2020cites this paper
• Elucidation of the Mechanisms and Molecular Targets of Sanhuang Xiexin Decoction for Type 2 Diabetes Mellitus Based on Network Pharmacology

  2020cites this paper
• Integrative transcriptomic analysis of pancreatic islets from patients with prediabetes/type 2 diabetes

  2020cites this paper
• Angel or Devil ? - CDK8 as the new drug target.

  2020cites this paper
• MicroRNA-564 acts as a tumor suppressor by directly targeting CDK 16 in bladder carcinoma cell lines

  2019cites this paper
• Molecular mechanisms linking peri-implantitis and type 2 diabetes mellitus revealed by transcriptomic analysis

  2019cites this paper
• CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells.

  2019cites this paper
• Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels

  2019cites this paper
• NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

  2019cites this paper
• p-21 activated kinase as a molecular target for chemoprevention in 1 diabetes 2 3

  2018cites this paper
• The Role Of Cdk8 In Metastatic Growth Of Colon Cancer

  2018cites this paper
• Integrated analysis of the gene expression profile and DNA methylation profile of obese patients with type 2 diabetes

  2018cites this paper
• Effective litmus gene test for monitoring the quality of blood samples: Application to Alzheimer’s disease diagnostics

  2017cites this paper
• Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

  2017cites this paper
• Retraction Note: Up-regulation of CDK16 by multiple mechanisms in hepatocellular carcinoma promotes tumor progression

  2017cites this paper
• CDK1 promotes nascent DNA synthesis and induces resistance of cancer cells to DNA-damaging therapeutic agents

  2017cites this paper
• Up-regulation of CDK16 by multiple mechanisms in hepatocellular carcinoma promotes tumor progression

  2017cites this paper
• Islet biology, the CDKN2A/B locus and type 2 diabetes risk

  2016cites this paper
• Definition of a Skp2-c-Myc Pathway to Expand Human Beta-cells

  2016cites this paper
• Differential expression network analysis for diabetes mellitus type 2 based on expressed level of islet cells.

  2016cites this paper
• RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes.

  2016cites this paper
• Type 2 diabetes: genetic data sharing to advance complex disease research

  2016cites this paper
• Targeting cell cycle regulators in hematologic malignancies

  2015cites this paper
• Genetics of Type 2 Diabetes—Pitfalls and Possibilities

  2015cites this paper
• Tissue-Specific Molecular Biomarker Signatures of Type 2 Diabetes: An Integrative Analysis of Transcriptomics and Protein–Protein Interaction Data

  2015cites this paper
• Novel Roles of p21 in Apoptosis During Beta-Cell Stress in Diabetes

  2014cites this paper
• Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action

  2014cites this paper
• Molecular Mechanisms of Cell Cycle Regulation in Pancreatic α- and β-cells that Control Glucose Homeostasis

  2014cites this paper