Notch signaling in hepatocellular carcinoma: molecular targeting in an advanced disease

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Hepatoma Research

• Publication date

  2015-04-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.4103/2394-5079.154132
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Modulation of Notch signaling as a therapeutic approach for liver cancer.

  2015cited by this paper
• Transarterial chemoembolization for primary liver malignancies and colorectal liver metastasis.

  2015cited by this paper
• Emerging roles of Notch signaling in liver disease

  2015cited by this paper
• Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma.

  2014cited by this paper
• Proteomics of a fuzzy organelle: interphase chromatin

  2014cited by this paper
• Pretreatment MicroRNA Level and Outcome in Sorafenib-treated Hepatocellular Carcinoma

  2014cited by this paper
• Changing Hepatocellular Carcinoma Incidence and Liver Cancer Mortality Rates in the United States

  2014cited by this paper
• Therapeutic modulation of Notch signalling — are we there yet?

  2014cited by this paper
• Introduction to Notch signaling.

  2014cited by this paper
• Notch signaling and new therapeutic options in liver disease.

  2014cited by this paper
• Cross‐talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice

  2013cited by this paper
• Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3β phosphorylation and p21 down-regulation in hepatocellular carcinoma

  2013cited by this paper
• Notch inhibitors for cancer treatment.

  2013cited by this paper
• Notch3 functions as a tumor suppressor by controlling cellular senescence.

  2013cited by this paper
• Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice.

  2013cited by this paper
• A critical role for notch signaling in the formation of cholangiocellular carcinomas.

  2013cited by this paper
• Notch-driven carcinogenesis: the merging of hepatocellular cancer and cholangiocarcinoma into a common molecular liver cancer subtype.

  2013cited by this paper
• Overexpression of the Notch3 receptor and its ligand Jagged1 in human clinically non-functioning pituitary adenomas

  2013cited by this paper
• Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers.

  2013cited by this paper
• ShRNA targeting Notch1 sensitizes breast cancer stem cell to paclitaxel.

  2013influential reference
• Notch signalling beyond liver development: emerging concepts in liver repair and oncogenesis.

  2013cited by this paper
• Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

  2012cited by this paper
• Notch3 overexpression as potential therapeutic target in advanced stage chemoresistant ovarian cancer.

  2012cited by this paper
• Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib.

  2012cited by this paper
• Liver regeneration.

  2012cited by this paper
• Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice.

  2012influential reference
• Expression features of SOX9 associate with tumor progression and poor prognosis of hepatocellular carcinoma

  2012cited by this paper
• Hedgehog controls hepatic stellate cell fate by regulating metabolism.

  2012cited by this paper
• Notch1 signaling contributes to the oncogenic effect of HBx on human hepatic cells

  2012cited by this paper
• The microcosmos of cancer

  2012cited by this paper
• PI3K signalling: the path to discovery and understanding

  2012cited by this paper
• Notch signaling in hepatocellular carcinoma: guilty in association!

  2012cited by this paper
• Notch signalling in solid tumours: a little bit of everything but not all the time

  2011cited by this paper
• New concepts in liver regeneration

  2011cited by this paper
• The global epidemiology of hepatocellular carcinoma: present and future.

  2011cited by this paper
• Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway

  2011cited by this paper
• Liver regeneration: alternative epithelial pathways.

  2011cited by this paper
• MicroRNA-122 sensitizes HCC cancer cells to adriamycin and vincristine through modulating expression of MDR and inducing cell cycle arrest.

  2011cited by this paper
• Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation.

  2010cited by this paper
• Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

  2010cited by this paper
• Therapeutic antibody targeting of individual Notch receptors

  2010cited by this paper
• Notch 1 signaling is active in ovarian cancer.

  2010cited by this paper
• Canonical and non-canonical Notch ligands.

  2010cited by this paper
• Evaluation of Selective γ-Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design

  2010cited by this paper
• [Targeted therapies in hepatocellular carcinoma].

  2010cited by this paper
• Down‐regulation of the Notch pathway mediated by a γ‐secretase inhibitor induces anti‐tumour effects in mouse models of T‐cell leukaemia

  2009cited by this paper
• MicroRNA-122 Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells and Sensitizes These Cells to Sorafenib*

  2009cited by this paper
• Selective ablation of Notch3 in HCC enhances doxorubicin's death promoting effect by a p53 dependent mechanism.

  2009cited by this paper
• Hepatocellular Carcinoma – Epidemiological Trends and Risk Factors

  2009cited by this paper
• Notch signaling: the core pathway and its posttranslational regulation.

  2009cited by this paper
• Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells.

  2008cited by this paper
• Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3*

  2008cited by this paper
• Profiling MicroRNA Expression in Hepatocellular Carcinoma Reveals MicroRNA-224 Up-regulation and Apoptosis Inhibitor-5 as a MicroRNA-224-specific Target*

  2008cited by this paper
• MicroRNA involvement in hepatocellular carcinoma

  2008cited by this paper
• A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis.

  2008cited by this paper
• Sorafenib in advanced hepatocellular carcinoma.

  2008cited by this paper
• Transcatheter Arterial Chemoembolization (TACE) in Hepatocellular Carcinoma (HCC): The Role of Angiogenesis and Invasiveness

  2008cited by this paper
• Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma

  2007cited by this paper
• Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells.

  2007cited by this paper
• Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors.

  2007cited by this paper
• FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

  2007cited by this paper
• Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion.

  2007cited by this paper
• The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

  2007cited by this paper
• Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

  2006cited by this paper
• Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease

  2006cited by this paper
• NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway.

  2006cited by this paper
• Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

  2006cited by this paper
• Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.

  2006cited by this paper
• Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice

  2005cited by this paper
• Faculty Opinions recommendation of Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

  2005cited by this paper
• Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling.

  2005cited by this paper
• Staging systems in hepatocellular carcinoma.

  2005cited by this paper
• Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma

  2005cited by this paper
• Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

  2004cited by this paper
• Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors

  2004cited by this paper
• Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival

  2003cited by this paper
• Notch signaling and inherited disease syndromes.

  2003cited by this paper
• Notch Signaling in Cancer

  2002cited by this paper
• The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

  2002cited by this paper
• International trends and patterns of primary liver cancer

  2001cited by this paper
• Notch signaling: from the outside in.

  2000cited by this paper
• Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells.

  1999influential reference
• Mutations in the human Jagged1 gene are responsible for Alagille syndrome

  1997cited by this paper
• Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

  1997cited by this paper
• Alagille syndrome with interstitial 20p deletion derived from maternal ins(7;20).

  1996cited by this paper
• The generation of cell diversity during early neurogenesis in Drosophila.

  1992cited by this paper
• TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.

  1991cited by this paper
• Xotch, the Xenopus homolog of Drosophila notch.

  1990cited by this paper
• The glp-1 locus and cellular interactions in early C. elegans embryos.

  1987cited by this paper
• glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans.

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• Hepatocellular carcinoma.

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• Cellular, Molecular and Proteomic Characteristics of Early Hepatocellular Carcinoma

  2022cites this paper
• Elucidating the Molecular Basis of Sorafenib Resistance in HCC: Current Findings and Future Directions

  2021cites this paper
• Increased Expression of Fibulin-1 Is Associated With Hepatocellular Carcinoma Progression by Regulating the Notch Signaling Pathway

  2020cites this paper
• Inhibition of NOTCH signaling pathway chemosensitizes HCC CD133+ cells to vincristine and 5-fluorouracil through upregulation of BBC3.

  2020cites this paper
• Beyond its antioxidant properties: Quercetin targets multiple signalling pathways in hepatocellular carcinoma in rats.

  2019cites this paper
• The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective

  2019cites this paper
• Evaluation of the role of Notch1 expression in hepatic carcinogenesis with clinico-pathological correlation.

  2018cites this paper
• Potential Molecular Targets and Drugs for Treatment of Hepatocellular Carcinoma

  2017cites this paper
• Notch Signaling Components

  2016cites this paper
• Natural products and hepatocellular carcinoma: a review

  2015cites this paper