Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Virology

• Publication date

  2010-07-28

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/JVI.00898-10PMID 20668092PMCID PMC2937765
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases

  2010influential reference
• Practical application of bioinformatics by the multidisciplinary VIZIER consortium

  2010cited by this paper
• Ubiquitylation in innate and adaptive immunity

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• Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection

  2009influential reference
• Jalview Version 2—a multiple sequence alignment editor and analysis workbench

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• rtracklayer: an R package for interfacing with genome browsers

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• SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

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• PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production

  2008influential reference
• The intracellular sites of early replication and budding of SARS-coronavirus

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• Deubiquitination in virus infection

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• Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease

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• The Buccaneer software for automated model building

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• Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme.

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• Auto-Rickshaw: an automated crystal structure determination pipeline as an efficient tool for fast validation of an X-ray diffraction experiment

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• Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus

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• Binding site‐based classification of coronaviral papain‐like proteases†

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  1999influential reference
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  1999cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• Proteolytic Processing at the Amino Terminus of Human Coronavirus 229E Gene 1-Encoded Polyproteins: Identification of a Papain-Like Proteinase and Its Substrate

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• Refinement of macromolecular structures by the maximum-likelihood method.

  1997cited by this paper
• Ribosomal frameshifting viral RNAs.

  1995cited by this paper
• Identification of a trypsin-like serine proteinase domain encoded by ORF 1a of the coronavirus IBV.

  1995cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• Identification of the catalytic sites of a papain-like cysteine proteinase of murine coronavirus

  1993cited by this paper
• Putative papain‐related thiol proteases of positive‐strand RNA viruses Identification of rubi‐ and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi‐, α‐ and coronaviruses

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• Identification of a domain required for autoproteolytic cleavage of murine coronavirus gene A polyprotein

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• Evaluation of Single-Crystal X-ray Diffraction Data from a Position-Sensitive Detector

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• Translation and processing of mouse hepatitis virus virion RNA in a cell-free system

  1986cited by this paper
• Electronic Reprint Biological Crystallography Application of the Complex Multivariate Normal Distribution to Crystallographic Methods with Insights into Multiple Isomorphous Replacement Phasing Biological Crystallography Application of the Complex Multivariate Normal Distribution to Crystallographic

  year unknowncited by this paper

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