The biochemical and phenotypic characterization of females homozygous for 5 alpha-reductase-2 deficiency.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Journal of Clinical Endocrinology and Metabolism

• Publication date

  1995-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/JCEM.80.11.7593420PMID 7593420
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A prospective randomized trial comparing finasteride to spironolactone in the treatment of hirsute women.

  1995cited by this paper
• Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism.

  1994cited by this paper
• Natural mutagenesis study of the human steroid 5 alpha-reductase 2 isozyme.

  1994cited by this paper
• The Syndrome of 5α-Reductase Deficiency:

  1994cited by this paper
• The Molecular Genetics of Steroid 5α-Reductases

  1994cited by this paper
• Effects of finasteride, a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women.

  1994cited by this paper
• Dihydrotestosterone regulation of semen in male pseudohermaphrodites with 5 alpha-reductase-2 deficiency.

  1994cited by this paper
• Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research.

  1993cited by this paper
• The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity.

  1993cited by this paper
• Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.

  1993cited by this paper
• Inverse relationship between ovarian aromatase cytochrome P450 and 5 alpha-reductase enzyme activities and mRNA levels during the estrous cycle in the rat.

  1992cited by this paper
• Structure of human type II 5 alpha-reductase gene.

  1992cited by this paper
• The Molecular Basis of Steroid 5α-Reductase Deficiency in a Large Dominican Kindred

  1992cited by this paper
• Molecular genetics of steroid 5 alpha-reductase 2 deficiency.

  1992cited by this paper
• Brief report: the molecular basis of steroid 5 alpha-reductase deficiency in a large Dominican kindred.

  1992cited by this paper
• Prostate visualization studies in males homozygous and heterozygous for 5 alpha-reductase deficiency.

  1992cited by this paper
• Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.

  1992cited by this paper
• Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism

  1991cited by this paper
• Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism.

  1991cited by this paper
• A cluster of male pseudohermaphrodites with 5 alpha-reductase deficiency in Papua New Guinea.

  1991cited by this paper
• Clinical and biochemical parameters of androgen action in normal healthy Caucasian versus Chinese subjects.

  1991cited by this paper
• Effect of dihydrotestosterone on the growth and function of ovarian follicles in intact immature female rats primed with PMSG.

  1990cited by this paper
• 5 alpha-reductase activity in polycystic ovary syndrome.

  1990cited by this paper
• Ultrasensitive two-site immunometric assay of human lutropin by time-resolved fluorometry.

  1990cited by this paper
• 5 α-reductase activity in polycystic ovary syndrome

  1990cited by this paper
• Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.

  1990cited by this paper
• Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction.

  1989cited by this paper
• Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

  1989cited by this paper
• A simple salting out procedure for extracting DNA from human nucleated cells.

  1988cited by this paper
• THE COEXISTENCE OF MALE PSEUDOHERMAPHRODITES WITH 17‐KETOSTEROID REDUCTASE DEFICIENCY AND 5α‐REDUCTASE DEFICIENCY WITHIN A TURKISH KINDRED

  1987cited by this paper
• Androstanediol glucuronide plasma clearance and production rates in normal and hirsute women.

  1986cited by this paper
• Periovulatory changes in serum concentration and ovarian content of 5 alpha-androstane-3 alpha, 17 beta-diol in the adult rat.

  1986cited by this paper
• Familial male pseudohermaphroditism due to 5-alpha-reductase deficiency in a Turkish village.

  1986cited by this paper
• Measurement of sebum output using a lipid absorbent tape.

  1986cited by this paper
• Contribution of plasma androstenedione to 5 alpha-androstanediol glucuronide in women with idiopathic hirsutism.

  1986cited by this paper
• URINARY STEROID METABOLITES IN SUBJECTS WITH MALE PSEUDOHERMAPHRODITISM DUE TO 5α‐REDUCTASE DEFICIENCY

  1985cited by this paper
• 5α-Reductase Activity in the Genital Skin of Hirsute Women*

  1985cited by this paper
• Decreased Urinary C19 and C21 Steroid 5α-Metabolites in Parents of Male Pseudohermaphrodites with 5α- Reductase Deficiency: Detection of Carriers*

  1985cited by this paper
• 5 alpha-Reductase activity in the genital skin of hirsute women.

  1985cited by this paper
• Decreased urinary C19 and C21 steroid 5 alpha-metabolites in parents of male pseudohermaphrodites with 5 alpha-reductase deficiency: detection of carriers.

  1985cited by this paper
• Elevated production and metabolic clearance rates of androgens in morbidly obese women.

  1984cited by this paper
• Androgen binding capacity and 5 alpha-reductase activity in pubic skin fibroblasts from hirsute patients.

  1983cited by this paper
• Evidence for the importance of peripheral tissue events in the development of hirsutism in polycystic ovary syndrome.

  1983cited by this paper
• Plasma 5 alpha-androstane-3 alpha,17 beta-diol and urinary 5 alpha-androstane-3 alpha,17 beta-diol glucuronide, parameters of peripheral androgen action: a comparative study.

  1982cited by this paper
• 3 alpha, 17 beta-androstanediol glucuronide in plasma. A marker of androgen action in idiopathic hirsutism.

  1982cited by this paper
• Is 3 alpha-androstanediol a marker of peripheral hirsutism?

  1982cited by this paper
• Estradiol, testosterone, and androstenedione in ovine follicular fluid during growth and atresia of ovarian follicles.

  1981cited by this paper
• Steroid 5 alpha-reductase deficiency in a 65-year-old male pseudohermaphrodite: the natural history, ultrastructure of the testes, and evidence for inherited enzyme heterogeneity.

  1980cited by this paper
• Effects of androgen on induction of gonadotropin receptors and gonadotropin-stimulated adenosine 3',5'-monophosphate production in rat ovarian granulosa cells.

  1980cited by this paper
• Alterations in granulosa cell aromatase activity accompanying preovulatory follicular development in the rat ovary with evidence that 5alpha-reduced C19 steroids inhibit the aromatase reaction in vitro.

  1980cited by this paper
• Metabolism of androstenedione by human ovarian tissues in vitro with particular reference to reductase and aromatase activity.

  1979cited by this paper
• The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro.

  1979cited by this paper
• Androgens and the evolution of male-gender identity among male pseudohermaphrodites with 5alpha-reductase deficiency.

  1979cited by this paper
• Metabolism of androstenedione by human ovarian tissues ? ? with particular reference to reductase and aromatase activity

  1979cited by this paper
• The microenvironment of the human antral follicle: interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of the oocyte in vivo and in vitro.

  1979cited by this paper
• Male pseudohermaphroditism secondary to 5 alpha-reductase deficiency--a model for the role of androgens in both the development of the male phenotype and the evolution of a male gender identity.

  1979cited by this paper
• Follicle stimulating hormone-induced follicular development: an examination of the role of androgens.

  1979cited by this paper
• Plasma 5α-Reduced Androgens in Men and Hirsute Women: Role of Adrenals and Gonads

  1979cited by this paper
• Hormonal regulation of 4-ENE-5α-reductase activity in prepubertal rat ovaries

  1978cited by this paper
• Hormonal regulation of 4-ene-5alpha-reductase activity in prepubertal rat ovaries.

  1978cited by this paper
• MALE PSEUDOHERMAPHRODITISM DUE TO STEROID 5α-REDUCTASE DEFICIENCY

  1977cited by this paper
• Male pseudohermaphroditism due to steroid 5-alpha-reductase deficiency.

  1977cited by this paper
• Changes in ovarian 5alpha-steroid reductase and 20alpha-hydroxysteroid dehydrogenase activity produced by induction of first ovulation with gonadotropin.

  1977cited by this paper
• Androgen production and skin metabolism in hirsutism.

  1977cited by this paper
• Male pseudohermaphroditism: the complexities of male phenotypic development.

  1976cited by this paper
• Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism.

  1975cited by this paper
• Evidence of a role of adrogens in follicular maturation.

  1975cited by this paper
• Interaction of estrogen and gonadotrophins on follicular atresia.

  1975cited by this paper
• Evidence for a Role of Androgens in Follicular Maturation

  1975cited by this paper
• In vitro conversion of testosterone-4-14C to androgens of the 5alpha-androstane series by a normal human ovary.

  1974cited by this paper
• Familial incomplete male pseudohermaphroditism, type 2. Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias.

  1974cited by this paper
• Steroid 5α-Reductase Deficiency in Man: An Inherited Form of Male Pseudohermaphroditism

  1974cited by this paper
• Simultaneous determination of urinary androstanediol and testosterone as an evaluation of human androgenicity.

  1973cited by this paper
• The metabolism of testosterone by human skin in disorders of hair growth.

  1973cited by this paper
• Studies on 5α-reductase activity in human ovarian tissue

  1971cited by this paper
• Further observations on the defective synthesis of ovarian steroids in the Stein-Leventhal syndrome.

  1962cited by this paper
• Clinical assessment of body hair growth in women.

  1961cited by this paper
• Defective Biosynthesis of Ovarian Steroids in the Stein-Leventhal Syndrome

  1961cited by this paper

• Identification of xenobiotics interfering with 5α-reductase (SRD5A2) activity.

  2026cites this paper
• The circulating dihydrotestosterone/testosterone ratio is increased by gut microbial 5α-reductase activity in females

  2025cites this paper
• Clinical, Hormonal, and Genetic Spectrum of 46 XY Disorders of Sexual Development (DSD) Patients

  2024cites this paper
• Identification of Key Proteins Related to Cashmere Fiber Diameter by Integrated Proteomics and Bioinformatic Analyses in the Alpas and Alxa Goat Breeds

  2024cites this paper
• The Molecular Basis of 5α-Reductase Type 2 Deficiency

  2022cites this paper
• Association of genetic polymorphisms with local steroid metabolism in human benign breasts.

  2021cites this paper
• Paternity in 5α-Reductase-2 Deficiency: Report of Two Brothers with Spontaneous or Assisted Fertility and Literature Review

  2019cites this paper
• Reprint of "Steroid 5α-reductase 2 deficiency".

  2017cites this paper
• 5α-Reductase Inhibitors in the Treatment of Benign Prostatic Hyperplasia: A Review

  2017cites this paper
• Ace rca de l mal de no minado «hirs utis mo idio pático »

  2016cites this paper
• Steroid 5α-reductase 2 deficiency.

  2016cites this paper
• 5-α-Reductase Deficiency Syndrome: An Experience from a Referral Hospital, Riyadh, Saudi Arabia

  2015cites this paper
• The value of middle phalangeal hair as an anthropometric marker: A review of the literature.

  2015cites this paper
• The effect of 5α-reductase-2 deficiency on human fertility.

  2014cites this paper
• 5 α -reductase-2 Deficiency’s Effect on Human Fertility

  2014cites this paper
• Clinical biochemistry of dihydrotestosterone

  2013cites this paper
• 5-Alpha-Reductase 2 Deficiency in a Woman with Primary Amenorrhea

  2013cites this paper
• The first successful paternity through in vitro fertilization-intracytoplasmic sperm injection with a man homozygous for the 5α-reductase-2 gene mutation.

  2011cites this paper
• Effect of finasteride on ovulation induction in nonresponder (hyperandrogenic) polycystic ovary syndrome (PCOS) women.

  2010cites this paper
• Clinical, hormonal, and molecular-genetic characteristics of three cases of 46XY disorder of sex development caused by type II 5-alpha reductase deficiency

  2010cites this paper
• Genetic Defects of Androgen Resistance

  2010cites this paper
• Disorders of sex development

  2009cites this paper
• Androgens—Molecular Basis and Related Disorders

  2009cites this paper
• CHAPTER 16 – The Testes: Disorders of Sexual Differentiation and Puberty in the Male

  2008cites this paper
• Detection of the G34R Mutation in the 5 Alpha Reductase 2 Gene by Allele Specific PCR and Its Linkage to the 89L Allele among Egyptian Cases

  2007cites this paper
• Anti-hormone Therapy: Principles of Endocrine Therapy of Cancer

  2006cites this paper
• Deficiência de 5alfa-redutase tipo 2: experiências de Campinas (SP) e Salvador (BA)

  2005cites this paper
• New mutations, hotspots, and founder effects in Brazilian patients with steroid 5α-reductase deficiency type 2

  2005cites this paper
• [5alpha-reductase type 2 deficiency: experiences from Campinas (SP) and Salvador (BA)].

  2005cites this paper
• Choice of gender in 5alpha-reductase deficiency: a moving target.

  2005cites this paper
• Choice of Gender in 5α-Reductase Deficiency: A Moving Target

  2005cites this paper
• Selective non-steroidal inhibitors of 5α-reductase type 1

  2004cites this paper
• Anomalies de la différenciation sexuelle

  2004cites this paper
• Selective non-steroidal inhibitors of 5 alpha-reductase type 1.

  2004cites this paper
• A Role for 5Alpha‐Reductase Activity in the Development of Male Homosexuality?

  2004cites this paper
• Effect of finasteride on the ovulatory function of normal women.

  2003cites this paper
• Prenatal exposures to phthalates among women in New York City and Krakow, Poland.

  2003cites this paper
• Molecular analysis of 5alpha-reductase type 2 gene in eight unrelated egyptian children with suspected 5alpha-reductase deficiency: prevalence of the G34R mutation.

  2003cites this paper
• Molecular analysis of 5α‐reductase type 2 gene in eight unrelated egyptian children with suspected 5α‐reductase deficiency: prevalence of the G34R mutation

  2003cites this paper
• Androgens and alopecia.

  2002cites this paper
• Factors affecting oestrogen action in the human prostate : does 5α-reductase type 1 isozyme have a role?

  2002cites this paper
• Mutations of the 5α-Steroid Reductase Type 2 Gene in Six Turkish Patients from Unrelated Families and a Large Pedigree of an Isolated Turkish Village

  2002cites this paper
• Androgens and male physiology the syndrome of 5alpha-reductase-2 deficiency.

  2002cites this paper
• Allelic frequencies of six polymorphic markers for risk of prostate cancer.

  2002cites this paper
• Androgens and male physiology the syndrome of 5α-reductase-2 deficiency

  2002cites this paper
• 5α-reductase inhibitors

  2001cites this paper
• Clinical application of 5α-reductase inhibitors

  2001cites this paper
• 5 alpha-Reductase inhibitors.

  2001cites this paper
• Clinical application of 5alpha-reductase inhibitors.

  2001cites this paper
• Terapia della calvizie e dell’irsutismo con inibitori della 5α-riduttasi

  2000cites this paper
• Acerca del mal denominado «hirsutismo idiopático»

  2000cites this paper
• Sex, kings and serial killers and other group-selected human traits.

  2000cites this paper
• [About the misnamed "idiopathic hirsutism"].

  2000cites this paper
• Neurosteroids

  1999cites this paper
• Androgen-activating enzymes in the central nervous system.

  1999cites this paper
• Aspects of Hormonal Steroid Metabolism in the Nervous System

  1999cites this paper
• New frameshift mutation in the 5α-reductase type 2 gene in a Brazilian patient with 5α-reductase deficiency

  1999cites this paper
• Androgen insensitivity.

  1999cites this paper
• Acquired scalp alopecia. Part II: A review

  1999cites this paper
• New frameshift mutation in the 5alpha-reductase type 2 gene in a Brazilian patient with 5alpha-reductase deficiency.

  1999cites this paper
• The identification of 5 alpha-reductase-2 and 17 beta-hydroxysteroid dehydrogenase-3 gene defects in male pseudohermaphrodites from a Turkish kindred.

  1998cites this paper
• Detection of Gly-196-Ser Mutation in 5α-Reductase Type II Gene in a Brazilian Patient with Female Assignment and Behavior

  1998cites this paper
• A novel mutation of the human luteinizing hormone receptor in 46XY and 46XX sisters.

  1998cites this paper
• 5 alpha-reductase isozymes in the central nervous system.

  1998cites this paper
• 5α-Reductase Isozymes in the Central Nervous System

  1998cites this paper
• Natural potent androgens: lessons from human genetic models.

  1998cites this paper
• Steroid metabolism in the mammalian brain: 5alpha-reduction and aromatization.

  1997cites this paper
• Paternity by intrauterine insemination with sperm from a man with 5alpha-reductase-2 deficiency.

  1997cites this paper
• Metabolism of steroids in the brain: a new insight into the role of 5alpha-reductase and aromatase in brain differentiation and functions.

  1996cites this paper
• Steroid receptors and action in the primate follicle.

  1996cites this paper
• Outcome of long-term treatment with the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism: clinical and hormonal effects during a 1-year course of therapy and 1-year follow-up.

  1996cites this paper