Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Molecular Biology of the Cell

• Publication date

  2007-11-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.E07-07-0728PMID 18032583PMCID PMC2230577
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

  2007cited by this paper
• Exploring the roles of Mus81-Eme1/Mms4 at perturbed replication forks.

  2007cited by this paper
• Synthetic Lethality of Drosophila in the Absence of the MUS81 Endonuclease and the DmBlm Helicase Is Associated With Elevated Apoptosis

  2007cited by this paper
• Genome‐wide characterization of fission yeast DNA replication origins

  2006cited by this paper
• Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication

  2006cited by this paper
• Genome‐wide replication profiles of S‐phase checkpoint mutants reveal fragile sites in yeast

  2006cited by this paper
• The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.

  2006cited by this paper
• The Bloom's Syndrome Helicase Can Promote the Regression of a Model Replication Fork*

  2006cited by this paper
• RuvAB is essential for replication forks reversal in certain replication mutants

  2006cited by this paper
• Checkpoint responses to replication fork barriers.

  2005cited by this paper
• BLM helicase facilitates Mus81 endonuclease activity in human cells.

  2005cited by this paper
• Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells.

  2005cited by this paper
• The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

  2005cited by this paper
• Temporal separation of replication and recombination requires the intra-S checkpoint

  2005cited by this paper
• Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.

  2005influential reference
• DNA replication origins fire stochastically in fission yeast.

  2005cited by this paper
• Gross chromosomal rearrangements and elevated recombination at an inducible site-specific replication fork barrier.

  2005cited by this paper
• The Fission Yeast Crb2/Chk1 Pathway Coordinates the DNA Damage and Spindle Checkpoint in Response to Replication Stress Induced by Topoisomerase I Inhibitor

  2005cited by this paper
• The DNA repair helicase UvrD is essential for replication fork reversal in replication mutants

  2004cited by this paper
• Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1.

  2004cited by this paper
• Swi1 and Swi3 Are Components of a Replication Fork Protection Complex in Fission Yeast

  2004cited by this paper
• Cds1 Phosphorylation by Rad3-Rad26 Kinase Is Mediated by Forkhead-associated Domain Interaction with Mrc1*

  2004cited by this paper
• DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51.

  2004influential reference
• Checkpoint-mediated control of replisome–fork association and signalling in response to replication pausing

  2004cited by this paper
• Swi1 Prevents Replication Fork Collapse and Controls Checkpoint Kinase Cds1

  2003cited by this paper
• The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism.

  2003influential reference
• DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1

  2003influential reference
• Checkpoint activation regulates mutagenic translesion synthesis.

  2003cited by this paper
• A central role for DNA replication forks in checkpoint activation and response.

  2003cited by this paper
• Role for the Fission Yeast RecQ Helicase in DNA Repair in G2

  2003cited by this paper
• Cleavage of Model Replication Forks by Fission Yeast Mus81-Eme1 and Budding Yeast Mus81-Mms4

  2003influential reference
• Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

  2002cited by this paper
• Mus81-Eme1 and Rqh1 Involvement in Processing Stalled and Collapsed Replication Forks*

  2002cited by this paper
• The chromosome replication cycle.

  2002cited by this paper
• Different Roles for Nonhomologous End Joining and Homologous Recombination following Replication Arrest in Mammalian Cells

  2002cited by this paper
• Maintenance of Genome Stability in Saccharomyces cerevisiae

  2002cited by this paper
• Regulation of replication timing in fission yeast

  2001cited by this paper
• Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

  2001cited by this paper
• The DNA replication checkpoint response stabilizes stalled replication forks

  2001cited by this paper
• RecA protein promotes the regression of stalled replication forks in vitro

  2001cited by this paper
• Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1

  2001cited by this paper
• Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled

  2001cited by this paper
• Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease.

  2001cited by this paper
• Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae.

  2001cited by this paper
• Mus81-Eme1 are essential components of a Holliday junction resolvase.

  2001influential reference
• Mrc1 transduces signals of DNA replication stress to activate Rad53

  2001cited by this paper
• RuvABC‐dependent double‐strand breaks in dnaBts mutants require RecA

  2000cited by this paper
• Damage Tolerance Protein Mus81 Associates with the FHA1 Domain of Checkpoint Kinase Cds1

  2000cited by this paper
• DNA structure checkpoint pathways in Schizosaccharomyces pombe.

  1999cited by this paper
• S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.

  1998influential reference
• RuvAB acts at arrested replication forks.

  1998cited by this paper
• Replication checkpoint enforced by kinases Cds1 and Chk1.

  1998cited by this paper
• A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

  1998cited by this paper
• DNA double‐strand breaks caused by replication arrest

  1997cited by this paper
• A kinase from fission yeast responsible for blocking mitosis in S phase

  1995influential reference
• A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage.

  1995cited by this paper
• Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.

  1994cited by this paper
• The fission yeast rad22 gene, having a function in mating-type switching and repair of DNA damages, encodes a protein homolog to Rad52 of Saccharomyces cerevisiae.

  1993cited by this paper
• Fission yeast genes involved in coupling mitosis to completion of DNA replication.

  1992cited by this paper
• Mitochondrial growth and DNA synthesis occur in the absence of nuclear DNA replication in fission yeast.

  1990cited by this paper

• S-phase checkpoint protects from aberrant replication fork processing and degradation

  2025cites this paper
• SNF2L suppresses nascent DNA gap formation to promote DNA synthesis

  2024cites this paper
• RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation.

  2023cites this paper
• Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae.

  2023cites this paper
• Roles of Claspin in regulation of DNA replication, replication stress responses and oncogenesis in human cells

  2021cites this paper
• Stimulation of adaptive gene amplification by origin firing under replication fork constraint

  2021influential citation
• Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant

  2020cites this paper
• An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases

  2020cites this paper
• Resolvases, Dissolvases, and Helicases in Homologous Recombination: Clearing the Road for Chromosome Segregation

  2020cites this paper
• Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins

  2020cites this paper
• Structure-Specific Endonucleases and the Resolution of Chromosome Underreplication

  2019cites this paper
• Chapter 13 DNA Replication Restart in Archaea

  2018cites this paper
• Preserving replication fork integrity and competence via the homologous recombination pathway

  2018influential citation
• An essential role for dNTP homeostasis following CDK-induced replication stress

  2018cites this paper
• Regulation of Structure-Specific Endonucleases in Replication Stress

  2018cites this paper
• Phosphorylation by CK2 regulates MUS81/EME1 in mitosis and after replication stress

  2018cites this paper
• Genetic Evidence for Roles of Yeast Mitotic Cyclins at Single-Stranded Gaps Created by DNA Replication

  2017cites this paper
• Quantitative DSB sequencing (qDSB-Seq): a method for genome-wide accurate estimation of absolute DNA double-strand break frequencies per cell

  2017cites this paper
• Integrated analysis of patterns of DNA breaks reveals break formation mechanisms and their population distribution during replication stress

  2017cites this paper
• Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts.

  2017cites this paper
• Control of structure-specific endonucleases to maintain genome stability

  2017cites this paper
• Building up and breaking down: mechanisms controlling recombination during replication

  2017cites this paper
• S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion

  2017cites this paper
• Dissecting the functions of atr in replication fork stability

  2017cites this paper
• Multi-BRCT domain protein Brc 1 links Rhp 18 / Rad 18 and γH 2 A to maintain 3 genome stability during S-phase

  2017cites this paper
• Feedback regulation of methyl methanesulfonate and ultraviolet-sensitive gene clone 81 via ATM/Chk2 pathway contributes to the resistance of MCF-7 breast cancer cells to cisplatin

  2017cites this paper
• The Intra-S Checkpoint Responses to DNA Damage

  2017cites this paper
• Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase

  2017cites this paper
• Dna Disentangled: Roles For Sgs1 And Top3 In Rec-X Resolution And Replication Fork Restart

  2016cites this paper
• Dynamique cellulaire des protéines de la réplication chez l'archée halophile Haloferax volcanii

  2016cites this paper
• Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability

  2016cites this paper
• Managing Single-Stranded DNA during Replication Stress in Fission Yeast

  2015cites this paper
• DNA Replication Restart in Archaea

  2015cites this paper
• Replication fork reversal in eukaryotes: from dead end to dynamic response

  2015cites this paper
• The impact of the chromatin regulators, Abo1 and HIRA, on global nucleosome architecture

  2015cites this paper
• Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex

  2015cites this paper
• Cancer therapy and replication stress: forks on the road to perdition.

  2015cites this paper
• Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast

  2015cites this paper
• Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S‐phase arrest and promoting apoptosis through CHK1 pathway

  2015cites this paper
• Srs2 promotes Mus81–Mms4-mediated resolution of recombination intermediates

  2015cites this paper
• Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress

  2015cites this paper
• Targeting lung cancer through inhibition of checkpoint kinases

  2015cites this paper
• Chromatin assembly by CAF-1 during homologous recombination: A novel step of regulation

  2015cites this paper
• ATR suppresses apoptosis after UVB irradiation by controlling both translesion synthesis and alternative tolerance pathways

  2015cites this paper
• The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage

  2014cites this paper
• MECHANISMS MEDIATING REPLICATION FORK COLLAPSE AND PROCESSING IN CHECKPOINT DEFECTIVE CELLS

  2014cites this paper
• The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins

  2014cites this paper
• The Role of DNA Secondary Structures at Human Chromosomal Fragile Sites

  2014cites this paper
• Structure-specific endonucleases: guardians of fragile site stability.

  2014cites this paper
• The causes of replication stress and their consequences on genome stability and cell fate.

  2014cites this paper
• Fission Yeast Rad52 Phosphorylation Restrains Error Prone Recombination Pathways

  2014cites this paper
• Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function

  2013cites this paper
• Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes

  2013cites this paper
• Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage

  2013cites this paper
• Replication stress and genome rearrangements: lessons from yeast models.

  2013cites this paper
• Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover

  2013cites this paper
• Regulation of Mus81–Eme1 Holliday junction resolvase in response to DNA damage

  2013cites this paper
• RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells

  2013cites this paper
• The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation

  2013cites this paper
• The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design.

  2013cites this paper
• Rescuing stalled or damaged replication forks.

  2013cites this paper
• Preserving the Replication Fork in Response to Nucleotide Starvation: Evading the Replication Fork Collapse Point

  2013cites this paper
• Studien zur Reparatur Camptothecin- und Methylmethansulfonat-induzierter DNA-Schäden

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• The Efficacy of CHK1 Inhibitors Is Not Altered by Hypoxia, but Is Enhanced after Reoxygenation

  2013cites this paper
• Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN.

  2012cites this paper
• Recovery of Arrested Replication Forks by Homologous Recombination Is Error-Prone

  2012cites this paper
• Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery

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• Genome instability induced by structured DNA and replication fork restart

  2012cites this paper
• Continued DNA Synthesis in Replication Checkpoint Mutants Leads to Fork Collapse

  2012influential citation
• Carboxy-terminal phosphorylation sites in Cdc25 contribute to enforcement of the DNA damage and replication checkpoints in fission yeast

  2012cites this paper
• Complex Chromosomal Rearrangements Mediated by Break-Induced Replication Involve Structure-Selective Endonucleases

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• Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes

  2011influential citation
• Analysis of stem cell genome stability and cancer-associated developmental programmes

  2011cites this paper
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• REGULATION OF THE CDC25 MITOTIC INDUCER FOLLOWING REPLICATION ARREST AND DNA DAMAGE

  2011cites this paper
• Structure-Specific DNA Endonuclease Mus81/Eme1 Generates DNA Damage Caused by Chk1 Inactivation

  2011cites this paper
• Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

  2011cites this paper
• Redundant Mechanisms Prevent Mitotic Entry Following Replication Arrest in the Absence of Cdc25 Hyper-Phosphorylation in Fission Yeast

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• Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

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• Histone H3K56 Acetylation, CAF1, and Rtt106 Coordinate Nucleosome Assembly and Stability of Advancing Replication Forks

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• Erratum to: Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes

  2011influential citation
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  2010cites this paper
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