PERK is responsible for the increased phosphorylation of eIF2α and the severe inhibition of protein synthesis after transient global brain ischemia

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Neurochemistry

• Publication date

  2005-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1471-4159.2005.03276.xPMID 16000157
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cytoprotection following endoplasmic reticulum stress protein induction in continuous cell lines.

  2004cited by this paper
• Regional impairment of protein synthesis following brief cerebral ischemia in the gerbil

  2004cited by this paper
• Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus

  2004cited by this paper
• Cytoprotection by pre‐emptive conditional phosphorylation of translation initiation factor 2

  2004cited by this paper
• Stress‐induced gene expression requires programmed recovery from translational repression

  2003cited by this paper
• Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses

  2003cited by this paper
• Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.

  2003cited by this paper
• Shutdown of Translation: Lethal or Protective? Unfolded Protein Response versus Apoptosis

  2003cited by this paper
• PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver.

  2003cited by this paper
• Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.

  2003cited by this paper
• Mechanisms of neuronal cell death: diverse roles of calcium in the various subcellular compartments.

  2003cited by this paper
• The Protein Kinase/Endoribonuclease IRE1α That Signals the Unfolded Protein Response Has a Luminal N-terminal Ligand-independent Dimerization Domain*

  2002cited by this paper
• The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

  2002cited by this paper
• Dimerization and Release of Molecular Chaperone Inhibition Facilitate Activation of Eukaryotic Initiation Factor-2 Kinase in Response to Endoplasmic Reticulum Stress*

  2002cited by this paper
• Mechanisms underlying suppression of protein synthesis induced by transient focal cerebral ischemia in mouse brain.

  2002cited by this paper
• Regulation of peptide-chain elongation in mammalian cells.

  2002cited by this paper
• Changes in the phosphorylation of initiation factor eIF‐2α, elongation factor eEF‐2 and p70 S6 kinase after transient focal cerebral ischaemia in mice

  2001cited by this paper
• Protein Aggregation after Focal Brain Ischemia and Reperfusion

  2001cited by this paper
• Initiation factor eIF2 alpha phosphorylation in stress responses and apoptosis.

  2001cited by this paper
• Initiation Factor eIF2α Phosphorylation in Stress Responses and Apoptosis

  2001cited by this paper
• Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK

  2001cited by this paper
• Protein Aggregation after Transient Cerebral Ischemia

  2000cited by this paper
• Role of calcium in neuronal cell injury: which subcellular compartment is involved?

  2000cited by this paper
• Regulated translation initiation controls stress-induced gene expression in mammalian cells.

  2000cited by this paper
• Perk is essential for translational regulation and cell survival during the unfolded protein response.

  2000cited by this paper
• Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

  2000influential reference
• Brain ischemia and reperfusion: molecular mechanisms of neuronal injury.

  2000cited by this paper
• Ischemic cell death in brain neurons.

  1999cited by this paper
• Insulin Induces Dephosphorylation of Eukaryotic Initiation Factor 2α and Restores Protein Synthesis in Vulnerable Hippocampal Neurons after Transient Brain Ischemia

  1999cited by this paper
• Protein synthesis inhibition by flavonoids: roles of eukaryotic initiation factor 2alpha kinases.

  1999cited by this paper
• Disturbances of the Functioning of Endoplasmic Reticulum: A Key Mechanism Underlying Neuronal Cell Injury?

  1999cited by this paper
• Eukaryotic Initiation Factor 2 a Kinase and Phosphatase Activity during Postischemic Brain Reperfusion

  1999cited by this paper
• Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

  1999cited by this paper
• Associate Editor: D. Shugar The 90-kDa Molecular Chaperone Family: Structure, Function, and Clinical Applications. A Comprehensive Review

  1998cited by this paper
• The development of a new mouse model of global ischemia: focus on the relationships between ischemia duration, anesthesia, cerebral vasculature, and neuronal injury following global ischemia in mice.

  1998cited by this paper
• Phosphorylation of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis in Response to Activation of the Double-stranded RNA-dependent Protein Kinase*

  1998cited by this paper
• Regulation of translational initiation during cellular responses to stress.

  1998cited by this paper
• BiP, a Major Chaperone Protein of the Endoplasmic Reticulum Lumen, Plays a Direct and Important Role in the Storage of the Rapidly Exchanging Pool of Ca2+ *

  1997cited by this paper
• Effect of Brain Ischemia and Reperfusion on the Localization of Phosphorylated Eukaryotic Initiation Factor 2α

  1997cited by this paper
• Neuroprotective nitric oxide synthase inhibitor reduces intracellular calcium accumulation following transient global ischemia in the gerbil.

  1997cited by this paper
• Ischemia‐Induced Inhibition of Calcium Uptake into Rat Brain Microsomes Mediated by Mg2+/Ca2+ ATPase

  1997cited by this paper
• Global Brain Ischemia and Reperfusion: Modifications in Eukaryotic Initiation Factors Associated with Inhibition of Translation Initiation

  1996cited by this paper
• Initiation of protein synthesis in eukaryotic cells.

  1996cited by this paper
• Depletion of Neuronal Endoplasmic Reticulum Calcium Stores by Thapsigargin: Effect on Protein Synthesis

  1996cited by this paper
• Calcium activity and post-ischemic suppression of protein synthesis

  1995cited by this paper
• Erythroid expression of the heme-regulated eIF-2 alpha kinase

  1994cited by this paper
• Phosphorylation of the alpha subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischaemia in the rat.

  1994cited by this paper
• Expression of a phosphorylation-resistant eukaryotic initiation factor 2 alpha-subunit mitigates heat shock inhibition of protein synthesis.

  1993cited by this paper
• Suppression of Protein Synthesis in the Reperfused Brain

  1993cited by this paper
• Disturbances of cerebral protein synthesis and ischemic cell death.

  1993cited by this paper
• Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP

  1991cited by this paper
• Tissue distribution and immunoreactivity of heme-regulated eIF-2 alpha kinase determined by monoclonal antibodies.

  1991cited by this paper
• Effect of barbiturate treatment on post-ischemic protein biosynthesis in gerbil brain.

  1989cited by this paper
• Four intracisternal calcium-binding glycoproteins from rat liver microsomes with high affinity for calcium. No indication for calsequestrin-like proteins in inositol 1,4,5-trisphosphate-sensitive calcium sequestering rat liver vesicles.

  1989cited by this paper
• Endoplasmic reticulum contains a common, abundant calcium-binding glycoprotein, endoplasmin.

  1986cited by this paper
• Preparation of a cell-free extract from rat brain which can initiate protein synthesis in vitro

  1986cited by this paper
• Changes in Brain Energy Metabolism and Protein Synthesis Following Transient Bilateral Ischemia in the Gerbil

  1985cited by this paper
• INTERNATIONAL SOCIETY FOR NEUROCHEMISTRY

  1976cited by this paper
• Initiation of the polypeptide chain by reticulocyte cell-free systems. Survey of different inhibitors of translation.

  1976cited by this paper
• Cerebral energy reserves after prolonged hypoxia and ischemia.

  1973cited by this paper
• Aurintricarboxylic acid: inhibitor of initiation of protein synthesis.

  1971cited by this paper
• Protein synthesis in the cat brain after prolonged cerebral ischemia.

  1971cited by this paper
• [Initiation of protein synthesis in eukaryotic cells].

  1969cited by this paper
• Cerebral ischemia. II. The no-reflow phenomenon.

  1968cited by this paper
• Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 a -Subunit Kinase, PEK, Involved in Translational Control

  year unknowncited by this paper
• Erythroid Expression of the Heme-Regulated eIF-2a Kinase

  year unknowncited by this paper

• Clemastine Reduces post-stroke Neurodegeneration by Alleviating Endoplasmic Reticulum stress-mediated Demyelination and Cognitive Impairment Through PERK/ATF4/CHOP Signaling Pathway

  2025cites this paper
• Mass spectrometry-based proteomics of FFPE tissues: progress, limitations, and clinical translation barriers

  2025cites this paper
• Protein Misfolding and Aggregation as a Mechanistic Link Between Chronic Pain and Neurodegenerative Diseases

  2025cites this paper
• Therapeutic Potential of Targeting the PERK Signaling Pathway in Ischemic Stroke

  2024cites this paper
• MAM-mediated mitophagy and endoplasmic reticulum stress: the hidden regulators of ischemic stroke

  2024cites this paper
• Time-Dependent Potentiation of the PERK Branch of UPR by GPR68 Offers Protection in Brain Ischemia

  2024cites this paper
• IRE1α regulates ROS and immune responses after UVB irradiation.

  2024cites this paper
• Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury

  2024cites this paper
• Astrocytic deletion of protein kinase R‐like ER kinase (PERK) does not affect learning and memory in aged mice but worsens outcome from experimental stroke

  2023cites this paper
• Ferroptosis and endoplasmic reticulum stress in ischemic stroke

  2023cites this paper
• PERK inhibitor, GSK2606414, ameliorates neuropathological damage, memory and motor functional impairments in cerebral ischemia via PERK/p-eIF2ɑ/ATF4/CHOP signaling

  2023cites this paper
• Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cerebral Ischemia/Reperfusion Injury

  2022cites this paper
• Pleckstrin homology-like domain, family A, member 1 (PHLDA1): A multifaceted cell survival factor that drives metabolic disease

  2022cites this paper
• Targeting autophagy, oxidative stress, and ER stress for neurodegenerative diseases treatment.

  2022cites this paper
• Endocrine-Disrupting Chemicals and Their Adverse Effects on the Endoplasmic Reticulum

  2022cites this paper
• Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2α and XBP-1 pathways after stroke.

  2022cites this paper
• Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice

  2021cites this paper
• The integrated stress response in ischemic diseases

  2021cites this paper
• An update on the unfolded protein response in brain ischemia: Experimental evidence and therapeutic opportunities.

  2021cites this paper
• Involvement of Kisspeptin in androgen-induced hypothalamic endoplasmic reticulum stress and its rescuing effect in PCOS rats.

  2021cites this paper
• CTRP1 Attenuates Cerebral Ischemia/Reperfusion Injury via the PERK Signaling Pathway

  2021cites this paper
• Mechanism of Endoplasmic Reticulum Stress in Cerebral Ischemia

  2021cites this paper
• 17β-oestradiol alleviates endoplasmic reticulum stress injury induced by chronic cerebral hypoperfusion through the Haemoglobin/HIF 1α signalling pathway in ovariectomized rats.

  2021cites this paper
• How cytosolic compartments play safeguard functions against neuroinflammation and cell death in cerebral ischemia

  2021cites this paper
• Insight into the effects of melatonin on endoplasmic reticulum, mitochondrial function, and their cross-talk in the stroke.

  2021cites this paper
• Mechanism and role of the intra-axonal Calreticulin translation in response to axonal injury.

  2020cites this paper
• PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis

  2020cites this paper
• Unfolded protein response in cardiovascular disease.

  2020cites this paper
• Proteostasis During Cerebral Ischemia

  2019cites this paper
• The double‐edged sword of endoplasmic reticulum stress in uremic sarcopenia through myogenesis perturbation

  2018cites this paper
• Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and γ-H2AX in colon cancer cells

  2017cites this paper
• Modulation of AβPP and GSK3β by Endoplasmic Reticulum Stress and Involvement in Alzheimer’s Disease

  2017cites this paper
• Regulation of mRNA following brain ischemia and reperfusion

  2017cites this paper
• Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death

  2017cites this paper
• Endoplasmic Reticulum Stress: An Opportunity for Neuroprotective Strategies After Stroke

  2017cites this paper
• Computer simulation of a large-scale signalling network regulating translation Initiation in the mammalian cell.

  2017cites this paper
• rAAV8-733-Mediated Gene Transfer of CHIP/Stub-1 Prevents Hippocampal Neuronal Death in Experimental Brain Ischemia.

  2017cites this paper
• Unfolded protein response in brain ischemia: A timely update

  2016cites this paper
• Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress- related signaling pathways

  2016cites this paper
• Calcineurin β protects brain after injury by activating the unfolded protein response

  2016cites this paper
• BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver.

  2016cites this paper
• Chemical chaperone 4-phenylbutyric acid protects H9c2 cardiomyocytes from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis.

  2016cites this paper
• Translational control by eIF2α in neurons: Beyond the stress response

  2016cites this paper
• The Dual Role of Serpins and Tissue-Type Plasminogen Activator During Stroke

  2015cites this paper
• Endoplasmic reticulum stress in cerebral ischemia.

  2014cites this paper
• Perk Gene Dosage Regulates Glucose Homeostasis by Modulating Pancreatic β-Cell Functions

  2014cites this paper
• Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries

  2014cites this paper
• Calpain cleaves methionine aminopeptidase-2 in a rat model of ischemia/reperfusion.

  2013cites this paper
• Endoplasmic reticulum dysfunction in neurological disease.

  2013cites this paper
• Potential roles of HDAC inhibitors in mitigating ischemia-induced brain damage and facilitating endogenous regeneration and recovery.

  2013cites this paper
• Consolidation of object recognition memory requires HRI kinase‐dependent phosphorylation of eIF2α in the hippocampus

  2013cites this paper
• p35 deficiency accelerates HMGB-1-mediated neuronal death in the early stages of an Alzheimer's disease mouse model.

  2013cites this paper
• Loss of endoplasmic reticulum Ca2+ homeostasis: contribution to neuronal cell death during cerebral ischemia

  2012cites this paper
• PKR-like endoplasmic reticulum kinase (PERK) activation following brain ischemia is independent of unfolded nascent proteins.

  2010cites this paper
• Critical role of eukaryotic translation initiation factor 4g degradation in mediating ischemia-induced neuronal death

  2009cites this paper
• Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation

  2009cites this paper
• CRITICAL ROLE OF EUKARYOTIC TRANSLATION INITIATION FACTOR 4G IN MEDIATING ISCHEMIA-INDUCED NEURONAL DEATH

  2009influential citation
• Translation arrest and ribonomics in post‐ischemic brain: layers and layers of players

  2008cites this paper
• A decrease in cellular energy status stimulates PERK-dependent eIF2α phosphorylation and regulates protein synthesis in pancreatic β-cells

  2008cites this paper
• A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic beta-cells.

  2008cites this paper
• A persistent translation arrest (TA) correlates with the delayed neuronal death (DND) of vulnerable neurons following brain ischemia and reperfusion

  2008cites this paper
• Olanzapine potentiates neuronal survival and neural stem cell differentiation: regulation of endoplasmic reticulum stress response proteins

  2007cites this paper
• Irreversible Translation Arrest in the Reperfused Brain

  2007cites this paper
• Translational Control and the Unfolded Protein Response

  2007cites this paper
• Regulatory proteins of eukaryotic initiation factor 2‐alpha subunit (eIF2α) phosphatase, under ischemic reperfusion and tolerance

  2007cites this paper
• The Eukaryotic Initiation Factor-2 Kinase Pathway Facilitates Differential GADD45a Expression in Response to Environmental Stress*

  2006cites this paper
• NFκB in neurons? The Uncertainty Principle in neurobiology

  2006cites this paper
• Microcephaly and simplified gyral pattern of the brain associated with early onset insulin-dependent diabetes mellitus

  2006cites this paper
• Irreversible aggregation of protein synthesis machinery after focal brain ischemia

  2006cites this paper
• NFkappaB in neurons? The uncertainty principle in neurobiology.

  2006cites this paper