The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem‐like cells

No abstract is available for this paper.

• Publication year

  2011

• Venue

  FEBS Letters

• Publication date

  2011-07-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2011.05.070PMID 21704033
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer

  2011cited by this paper
• Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo

  2010cited by this paper
• HER2/ErbB2-induced Breast Cancer Cell Migration and Invasion Require p120 Catenin Activation of Rac1 and Cdc42*

  2010cited by this paper
• Selective targeting of radiation-resistant tumor-initiating cells

  2010cited by this paper
• Rac and Rho GTPases in cancer cell motility control

  2010cited by this paper
• Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy

  2010cited by this paper
• SUMOylation of the GTPase Rac1 is required for optimal cell migration

  2010cited by this paper
• Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation.

  2010cited by this paper
• A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.

  2009cited by this paper
• DNA Repair and Resistance of Gliomas to Chemotherapy and Radiotherapy

  2009cited by this paper
• Rho GTPase function in tumorigenesis.

  2009cited by this paper
• Mechanisms of stem cell self-renewal.

  2009cited by this paper
• Faculty Opinions recommendation of Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.

  2008cited by this paper
• Comparison between cells and cancer stem-like cells isolated from glioblastoma and astrocytoma on expression of anti-apoptotic and multidrug resistance-associated protein genes.

  2008cited by this paper
• Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling

  2008cited by this paper
• Tumorigenesis and Neoplastic Progression A Critical Role for Rac1 in Tumor Progression of Human Colorectal Adenocarcinoma Cells malignant phenotype

  2008cited by this paper
• Rho GTPases in cancer cell biology

  2008cited by this paper
• Paradoxical Expression of Anti-Apoptotic and MRP Genes on Cancer Stem-Like Cell Isolated from TJ905 Glioblastoma Multiforme Cell Line

  2008cited by this paper
• Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance

  2007cited by this paper
• Long-term maintenance of brain tumor stem cell properties under at non-adherent and adherent culture conditions.

  2007cited by this paper
• Cancer stem cells and human malignant melanoma

  2007cited by this paper
• Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor.

  2006cited by this paper
• A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.

  2006cited by this paper
• Ephrin-B3 ligand promotes glioma invasion through activation of Rac1.

  2006cited by this paper
• A Clonogenic Survival Assay of Neural Stem Cells in Rat Spinal Cord after Exposure to Ionizing Radiation

  2005cited by this paper
• Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells

  2005cited by this paper
• Rho GTPase expression in tumourigenesis: Evidence for a significant link

  2005cited by this paper
• Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion

  2005cited by this paper
• Role of Synaptojanin 2 in Glioma Cell Migration and Invasion

  2004cited by this paper
• Overexpression of RhoA, Rac1, and Cdc42 GTPases Is Associated with Progression in Testicular Cancer

  2004cited by this paper
• Cancer stem cells in nervous system tumors

  2004cited by this paper
• Rac1 gene mutations in human brain tumours

  2004cited by this paper
• Engagement of CD44 Promotes Rac Activation and CD44 Cleavage during Tumor Cell Migration*

  2004cited by this paper
• Rac1 gene mutations in human brain tumours.

  2004cited by this paper
• Identification of a cancer stem cell in human brain tumors.

  2003cited by this paper
• RHO–GTPases and cancer

  2002cited by this paper
• Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres

  2002cited by this paper
• Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes.

  2002cited by this paper
• Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

  2000cited by this paper

• RAGE signaling pathway in glioblastoma and cognitive decline: Insights into inflammatory mechanisms and therapeutic implications.

  2025cites this paper
• Regulation of epithelial-mesenchymal plasticity in pancreatic ductal adenocarcinoma: Role of key molecules in tumor differentiation and therapy.

  2025cites this paper
• Activation of the Mevalonate Pathway in Response to Anti-cancer Treatments Drives Glioblastoma Recurrences Through Activation of Rac-1

  2024cites this paper
• Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1

  2023cites this paper
• DNMT3A/miR-129-2-5p/Rac1 Is an Effector Pathway for SNHG1 to Drive Stem-Cell-like and Invasive Behaviors of Advanced Bladder Cancer Cells

  2022cites this paper
• Preclinical Efficacy and Toxicology Evaluation of RAC1 Inhibitor 1A-116 in Human Glioblastoma Models

  2022cites this paper
• Rac1, A Potential Target for Tumor Therapy

  2021cites this paper
• Transcriptome analysis revealed differences in the microenvironment of spermatogonial stem cells in seminiferous tubules between pre-pubertal and adult buffaloes.

  2021cites this paper
• Role of Rho GTPases in stem cell regulation.

  2021cites this paper
• Activation of a Ductal-to-Endocrine Transdifferentiation Transcriptional Program in the Pancreatic Cancer Cell Line PANC-1 Is Controlled by RAC1 and RAC1b through Antagonistic Regulation of Stemness Factors

  2021cites this paper
• Cholesterol and beyond - The role of the mevalonate pathway in cancer biology.

  2020cites this paper
• mTORC2/Rac1 Pathway Predisposes Cancer Aggressiveness in IDH1-Mutated Glioma

  2020cites this paper
• LncRNA NR2F2-AS1 Upregulates Rac1 to Increase Cancer Stemness in Clear Cell Renal Cell Carcinoma

  2020cites this paper
• Rho GTPases: Promising Candidates for Overcoming Chemotherapeutic Resistance.

  2020cites this paper
• Rho GTPases in cancer radiotherapy and metastasis

  2020cites this paper
• DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits

  2020cites this paper
• RAS-mediated oncogenic signaling pathways in human malignancies.

  2019cites this paper
• TIAM1 promotes chemoresistance and tumor invasiveness in colorectal cancer

  2019cites this paper
• Aberrant Rac pathway signalling in glioblastoma

  2019cites this paper
• Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase

  2018cites this paper
• Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics.

  2018cites this paper
• Long Noncoding RNA TUNAR Represses Growth, Migration, and Invasion of Human Glioma Cells Through Regulating miR-200a and Rac1

  2018cites this paper
• Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo

  2017cites this paper
• Reactive Oxygen Species-Mediated Autophagy Defines the Fate of Cancer Stem Cells

  2017cites this paper
• miR-142 inhibits the migration and invasion of glioma by targeting Rac1.

  2017cites this paper
• Simultaneous Interference with HER1/EGFR and RAC1 Signaling Drives Cytostasis and Suppression of Survivin in Human Glioma Cells in Vitro

  2017cites this paper
• Targeting Rho, Rac, CDC42 GTPase Effector p21 Activated Kinases in Mutant K-Ras-Driven Cancer

  2017cites this paper
• The role of β1-integrin in mammary stem and progenitor fate

  2016influential citation
• ould drugs inhibiting the mevalonate pathway also target cancer tem cells ?

  2016cites this paper
• Targeting ROR1 inhibits the self‐renewal and invasive ability of glioblastoma stem cells

  2016cites this paper
• RhoGDIα suppresses self-renewal and tumorigenesis of glioma stem cells

  2016cites this paper
• Rac1 and EMT: a dangerous liaison?

  2016cites this paper
• Could drugs inhibiting the mevalonate pathway also target cancer stem cells?

  2016cites this paper
• Inference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of Cancer

  2015cites this paper
• Dynamic interaction between glioma cells and their microenvironment: targeting Rac1 as a therapeutic approach

  2015cites this paper
• Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways.

  2015cites this paper
• Three-dimensional constructs using hyaluronan cell carrier as a tool for the study of cancer stem cells.

  2015cites this paper
• The Rab2A GTPase Promotes Breast Cancer Stem Cells and Tumorigenesis via Erk Signaling Activation

  2015cites this paper
• Putative biomarkers and therapeutic targets associated with radiation resistance

  2014cites this paper
• Glycogen Synthase Kinase 3β Sustains Invasion of Glioblastoma via the Focal Adhesion Kinase, Rac1, and c-Jun N-Terminal Kinase-Mediated Pathway

  2014cites this paper
• Prognostic Biomarkers and Target Proteins for Treatment of High-grade Gliomas

  2014cites this paper
• Proapoptotic and antiinvasive activity of rac1 small molecule inhibitors on malignant glioma cells

  2014cites this paper
• Three-dimensional patterning of multiple cell populations through orthogonal genetic control of cell motility.

  2014cites this paper
• Proteomics of cancer stem cells

  2014cites this paper
• Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells

  2014cites this paper
• Rho GTPases and cancer

  2014cites this paper
• Therapeutic strategies targeting glioblastoma stem cells.

  2013cites this paper
• Combined Inhibition of HER1/EGFR and RAC1 Results in a Synergistic Antiproliferative Effect on Established and Primary Cultured Human Glioblastoma Cells

  2013cites this paper
• Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression

  2013cites this paper
• Synergistic interactions between camptothecin and EGFR or RAC1 inhibitors and between imatinib and Notch signaling or RAC1 inhibitors in glioblastoma cell lines

  2013cites this paper
• The cancer stem cell niche(s): the crosstalk between glioma stem cells and their microenvironment.

  2013cites this paper
• Characteristic Features of Stem Cells in Glioblastomas: From Cellular Biology to Genetics

  2012cites this paper
• Chemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrest

  2012cites this paper
• Oncotargets and Therapy Dovepress Dovepress Proapoptotic and Antiinvasive Activity of Rac1 Small Molecule Inhibitors on Malignant Glioma Cells

  year unknowncites this paper