A concerted action of HNF4α and HNF1α links hepatitis B virus replication to hepatocyte differentiation

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cellular Microbiology

• Publication date

  2008-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1462-5822.2008.01141.xPMID 18346225
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
• Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection.

  2007influential reference
• PGC-1α controls hepatitis B virus through nutritional signals

  2006influential reference
• PGC-1alpha controls hepatitis B virus through nutritional signals.

  2006influential reference
• Characterization of a hepatitis B and hepatitis delta virus receptor binding site

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• Dendritic cells take up viral antigens but do not support the early steps of hepatitis B virus infection

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• Phenobarbital regulates nuclear expression of HNF‐4α in mouse and rat hepatocytes independent of CAR and PXR

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• Hepatocyte nuclear factor 4 (cid:1) orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver

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• Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes.

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• Characterization of sequence variations in human histone H1.2 and H1.4 subtypes

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• Regulation of Hepatitis B Virus Core Promoter by Transcription Factors HNF1 and HNF4 and the Viral X Protein

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• Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

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• Distinct Modes of Regulation of Transcription of Hepatitis B Virus by the Nuclear Receptors HNF4α and COUP-TF1

  2003cited by this paper
• The role of hepatocytes and oval cells in liver regeneration and repopulation.

  2003cited by this paper
• Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis

  2003influential reference
• Primary human hepatocytes--a valuable tool for investigation of apoptosis and hepatitis B virus infection.

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• Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β

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• Infection of a human hepatoma cell line by hepatitis B virus

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• Analysis of gene expression profile induced by hepatocyte nuclear factor 4α in hepatoma cells using an oligonucleotide microarray

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• Analysis of Gene Expression Profile Induced by Hepatocyte Nuclear Factor 4α in Hepatoma Cells Using an Oligonucleotide Microarray*

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• Optimised Conditions for the Production of Hepatitis B Virus from Cell Culture

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• Nuclear Covalently Closed Circular Viral Genomic DNA in the Liver of Hepatocyte Nuclear Factor 1α-Null Hepatitis B Virus Transgenic Mice

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• Transfer of Hepatitis B Virus Genome by Adenovirus Vectors into Cultured Cells and Mice: Crossing the Species Barrier

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• Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

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• Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism.

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• Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

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• Native display of complete foreign protein domains on the surface of hepatitis B virus capsids.

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• Members of the nuclear receptor superfamily regulate transcription from the hepatitis B virus nucleocapsid promoter

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• Hepatitis B virus replication is cell cycle independent during liver regeneration in transgenic mice

  1997cited by this paper
• Type, prevalence, and significance of core promoter/enhancer II mutations in hepatitis B viruses from immunosuppressed patients with severe liver disease

  1996cited by this paper
• Effect of hepatocyte proliferation and cellular DNA synthesis on hepatitis B virus replication.

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• Promoters for synthesis of the pre-C and pregenomic mRNAs of human hepatitis B virus are genetically distinct and differentially regulated

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• Characterization of a functional hepatocyte nuclear factor 3 binding site in the hepatitis B virus nucleocapsid promoter.

  1995cited by this paper
• Hepatitis B virus enhancer binds and is activated by the Hepatocyte nuclear factor 3.

  1995cited by this paper
• Characterization of the hepatitis B virus large surface antigen promoter Sp1 binding site.

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• Regulation of transcription from the hepatitis B virus large surface antigen promoter by hepatocyte nuclear factor 3

  1995cited by this paper
• Differentiated liver cell specificity of the second enhancer of hepatitis B virus

  1993cited by this paper
• Differential patterns of expression of three C/EBP isoforms, HNF-1, and HNF-4 after partial hepatectomy in rats.

  1993cited by this paper
• Regulation of hepatitis B virus gene expression by its two enhancers.

  1992cited by this paper
• Transcriptional factor C/EBP binds to and transactivates the enhancer element II of the hepatitis B virus.

  1991cited by this paper
• Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: trans-activation and repression by CCAAT/enhancer binding protein.

  1990cited by this paper
• Differentiation-specific transcriptional regulation of the hepatitis B virus large surface antigen gene in human hepatoma cell lines

  1990cited by this paper
• Translational inactivation of RNA function: discrimination against a subset of genomic transcripts during HBV nucleocapsid assembly.

  1990cited by this paper
• Identification of a promoter region for 3.6-kilobase mRNA of hepatitis B virus and specific cellular binding protein

  1989influential reference
• The surface gene promoter of the human hepatitis B virus displays a preference for differentiated hepatocytes.

  1989cited by this paper
• Regulation by dimethylsulfoxide, insulin, and corticosteroids of hepatitis b virus replication in a transfected human hepatoma cell line

  1989cited by this paper
• A liver-specific enhancer in the core promoter region of human hepatitis B virus.

  1989cited by this paper
• Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters.

  1988cited by this paper
• Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.

  1987influential reference
• A human hepatitis B viral enhancer element.

  1985cited by this paper
• Replication of the genome of a hepatitis B--like virus by reverse transcription of an RNA intermediate.

  1982cited by this paper

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• Identification of Slug and SOX7 as transcriptional repressors binding to the hepatitis B virus core promoter.

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• UvA-DARE (Digital Academic Repository) X: On the molecular biology of the hepatitis B virus X protein van de Klundert, M.A.A

  2016cites this paper
• Roles of hepatocyte nuclear factors in hepatitis B virus infection.

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• Attacking hepatitis B virus cccDNA--The holy grail to hepatitis B cure.

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• Hepatitis B Virus Protein X Induces Degradation of Talin-1

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• EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes.

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• Immune-mediated Liver Injury in Hepatitis B Virus Infection

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• A zebrafish model for subgenomic hepatitis C virus replication.

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• Hepatitis: Epigenetic control of HBV by HBx protein—releasing the break?

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• Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells

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• Endogenous antiviral microRNAs determine permissiveness for hepatitis B virus replication in cultured human fetal and adult hepatocytes

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• A new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses.

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• 5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice.

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• In vivo proliferation of hepadnavirus‐infected hepatocytes induces loss of covalently closed circular DNA in mice

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• Publication List 2008

  2009cites this paper
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