Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2011-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bbalip.2011.07.008PMID 21798367
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998influential reference

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  2016cites this paper
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  2016cites this paper
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