Structural Analysis and Ion Translocation Mechanisms of the Muscle-Type Acetylcholine Receptor Channel

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Applied Biomaterials & Functional Materials

• Publication date

  2013-01-01

• Fields of study

  Medicine, Physics, Chemistry

• Identifiers
  DOI 10.5301/JABFM.5000148PMID 23728540
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanical characterization of actomyosin complex by molecular mechanics simulations.

  2010cited by this paper
• Role of acetylcholine receptor domains in ion selectivity.

  2009influential reference
• Computational modeling study of human nicotinic acetylcholine receptor for developing new drugs in the treatment of alcoholism

  2009cited by this paper
• Computational study of the transmembrane domain of the acetylcholine receptor

  2009influential reference
• Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer

  2008cited by this paper
• Congenital Myasthenic Syndromes and the Formation of the Neuromuscular Junction

  2008cited by this paper
• In silico models for the human alpha4beta2 nicotinic acetylcholine receptor.

  2008influential reference
• Mechanics of Channel Gating of the Nicotinic Acetylcholine Receptor

  2008cited by this paper
• Barriers to ion translocation in cationic and anionic receptors from the Cys-loop family.

  2007influential reference
• Dynamics of heteropentameric nicotinic acetylcholine receptor: Implications of the gating mechanism

  2007cited by this paper
• Multi-Scale Analysis of the Toraymyxin Adsorption Cartridge Part I: Molecular Interaction of Polymyxin B with Endotoxins

  2006cited by this paper
• Channel opening motion of alpha7 nicotinic acetylcholine receptor as suggested by normal mode analysis.

  2006influential reference
• Statistical potential for assessment and prediction of protein structures

  2006cited by this paper
• Comparative Protein Structure Modeling Using Modeller

  2006cited by this paper
• An energy-efficient gating mechanism in the acetylcholine receptor channel suggested by molecular and Brownian dynamics.

  2006cited by this paper
• Homology modeling and molecular dynamics simulations of transmembrane domain structure of human neuronal nicotinic acetylcholine receptor.

  2005cited by this paper
• A hydrophobic gate in an ion channel: the closed state of the nicotinic acetylcholine receptor

  2005cited by this paper
• Refined structure of the nicotinic acetylcholine receptor at 4A resolution.

  2005influential reference
• Scalable molecular dynamics with NAMD

  2005cited by this paper
• Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism.

  2005influential reference
• The α7 nicotinic acetylcholine receptor: Molecular modelling, electrostatics, and energetics

  2005cited by this paper
• The alpha7 nicotinic acetylcholine receptor: molecular modelling, electrostatics, and energetics.

  2005cited by this paper
• Drugs of anesthesia, central nicotinic receptors and Parkinson's disease.

  2004cited by this paper
• ElNémo: a normal mode web server for protein movement analysis and the generation of templates for molecular replacement

  2004cited by this paper
• PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations

  2004cited by this paper
• Regulating the regulators: the role of nicotinic acetylcholine receptors in human epilepsy.

  2003cited by this paper
• Structure and gating mechanism of the acetylcholine receptor pore

  2003influential reference
• Normal mode analysis of macromolecular motions in a database framework: Developing mode concentration as a useful classifying statistic

  2002cited by this paper
• The nicotinic receptor ligand binding domain.

  2002cited by this paper
• Neuroreceptors and ion channels as targets of alcohol.

  2001cited by this paper
• Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

  2001cited by this paper
• Electrostatics of nanosystems: Application to microtubules and the ribosome

  2001cited by this paper
• High calcium permeability and calcium block of the alpha9 nicotinic acetylcholine receptor.

  2000cited by this paper
• High calcium permeability and calcium block of the α9 nicotinic acetylcholine receptor

  2000influential reference
• The cholinergic hypothesis of Alzheimer’s disease: a review of progress

  1999cited by this paper
• Behavioural status during the intracarotid amobarbital procedure (Wada test): relevance for surgical management

  1999cited by this paper
• Electrostatics and the ion selectivity of ligand-gated channels.

  1998cited by this paper
• Ca2+ permeability of mouse and chick nicotinic acetylcholine receptors expressed in transiently transfected human cells

  1998cited by this paper
• Functional nicotinic ACh receptors on interneurones in the rat hippocampus

  1997cited by this paper
• VMD: visual molecular dynamics.

  1996influential reference
• Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.

  1995cited by this paper
• Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

  1995cited by this paper
• Protein electrostatics: rapid multigrid-based Newton algorithm for solution of the full nonlinear Poisson-Boltzmann equation.

  1994cited by this paper
• Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors.

  1992influential reference
• CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

  1983cited by this paper
• Review: Ionic hydration in chemistry and biophysics, by B. E. Conway, Elsevier Publishing Company, 1981

  1982cited by this paper
• The permeability of endplate channels to monovalent and divalent metal cations

  1980cited by this paper
• Effects of permeant monovalent cations on end‐plate channels.

  1979cited by this paper
• Selectivity of cations and nonelectrolytes for acetylcholine-activated channels in cultured muscle cells

  1978cited by this paper
• Permeability of the endplate membrane activated by acetylcholine to some organic cations.

  1977cited by this paper

• A Missense Mutation in Epsilon-subunit of Acetylcholine Receptor Causing Autosomal Dominant Slow-channel Congenital Myasthenic Syndrome in a Chinese Family

  2016cites this paper