Thermodynamics of ABC transporters

ABSTRACTABC transporters form the largest of all transporter families, and their structural study has made tremendous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and the conformational changes following substrate binding remain to be elucidated. Here, we present our thermodynamic analysis for both ABC importers and exporters, and introduce the two new concepts of differential-binding energy and elastic conformational energy into the discussion. We hope that the structural analysis of ABC transporters will henceforth take thermodynamic aspects of transport mechanisms into account as well.

• Publication year

  2015

• Venue

  Protein & Cell

• Publication date

  2015-09-25

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s13238-015-0211-zPMID 26408021PMCID 4707154
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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