2,3‐Dehydrosilybin A/B as a pro‐longevity and anti‐aggregation compound

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Free Radical Biology & Medicine

• Publication date

  2017-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.freeradbiomed.2016.12.042PMID 28039083
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Silibinin and its 2,3‐dehydro‐derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation

  2016cited by this paper
• Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity.

  2016cited by this paper
• Phycocyanin moderates aging and proteotoxicity in Caenorhabditis elegans

  2016cited by this paper
• Distinct stress conditions result in aggregation of proteins with similar properties

  2016cited by this paper
• 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures

  2016cited by this paper
• Effects of 2,3-Dehydrosilybin and Its Galloyl Ester and Methyl Ether Derivatives on Human Umbilical Vein Endothelial Cells.

  2016cited by this paper
• Silymarin

  2015cited by this paper
• Silymarin component 2,3-dehydrosilybin attenuates cardiomyocyte damage following hypoxia/reoxygenation by limiting oxidative stress.

  2015cited by this paper
• Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer's model.

  2015cited by this paper
• 20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans

  2015cited by this paper
• Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases.

  2015cited by this paper
• Facilitative glucose transporter and its regulation by insulin/IGF-like signaling in Caenorhabditis elegans

  2015cited by this paper
• Bioavailability of silymarin flavonolignans: drug formulations and biotransformation

  2014cited by this paper
• Preparatory separation of the silymarin flavonolignans by Sephadex LH-20 gel

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
• New Concepts in Nutraceuticals as Alternative for Pharmaceuticals

  2014cited by this paper
• Chemistry of silybin.

  2014cited by this paper
• The ubiquitin proteasome system in Caenorhabditis elegans and its regulation☆

  2014cited by this paper
• Protein damage, repair and proteolysis.

  2014cited by this paper
• The oxidative stress hypothesis in Alzheimer's disease.

  2013cited by this paper
• The hallmarks of aging.

  2013cited by this paper
• FGT-1 Is a Mammalian GLUT2-Like Facilitative Glucose Transporter in Caenorhabditis elegans Whose Malfunction Induces Fat Accumulation in Intestinal Cells

  2013influential reference
• Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit

  2013cited by this paper
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  2013cited by this paper
• Neuroprotective Potential of Silymarin against CNS Disorders: Insight into the Pathways and Molecular Mechanisms of Action

  2013cited by this paper
• Dimethyl sulfoxide and dimethyl formamide increase lifespan of C. elegans in liquid.

  2013cited by this paper
• Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture

  2013cited by this paper
• Base-catalyzed oxidation of silybin and isosilybin into 2,3-dehydro derivatives

  2013cited by this paper
• RPN-6 determines C. elegans longevity under proteotoxic stress conditions

  2012cited by this paper
• NIH Image to ImageJ: 25 years of image analysis

  2012cited by this paper
• Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

  2012cited by this paper
• Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins

  2011influential reference
• Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

  2011cited by this paper
• Silibinin: a novel inhibitor of Aβ aggregation.

  2011cited by this paper
• Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar rats.

  2011cited by this paper
• [Determination of active components in silymarin by UPLC-ESIMS].

  2011cited by this paper
• Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection

  2010cited by this paper
• A Comparative Study of Fat Storage Quantitation in Nematode Caenorhabditis elegans Using Label and Label-Free Methods

  2010cited by this paper
• Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: involvement of estrogen receptors and oxidative stress.

  2010cited by this paper
• Large-scale separation of silybin diastereoisomers using lipases

  2010cited by this paper
• The hormetic role of dietary antioxidants in free radical-related diseases.

  2010cited by this paper
• Polyunsaturated fatty acids are involved in regulatory mechanism of fatty acid homeostasis via daf-2/insulin signaling in Caenorhabditis elegans.

  2010cited by this paper
• ilibinin attenuates cognitive deficits and decreases of dopamine and serotonin nduced by repeated methamphetamine treatment

  2010cited by this paper
• Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model

  2010cited by this paper
• Glucose transporters in the 21st Century.

  2010cited by this paper
• Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism

  2010cited by this paper
• Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16.

  2010cited by this paper
• Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain.

  2009cited by this paper
• Silibinin Attenuates Amyloid (cid:1) 25–35 Peptide-Induced Memory Impairments: Implication of Inducible Nitric-Oxide Synthase and Tumor Necrosis Factor- (cid:2) in Mice

  2009cited by this paper
• Silibinin Attenuates Amyloid β25–35 Peptide-Induced Memory Impairments: Implication of Inducible Nitric-Oxide Synthase and Tumor Necrosis Factor-α in Mice

  2009cited by this paper
• Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity--role of individual hydroxyl groups.

  2009cited by this paper
• Multitargeted therapy of cancer by silymarin.

  2008cited by this paper
• Mechanism of the antioxidant action of silybin and 2,3-dehydrosilybin flavonolignans: a joint experimental and theoretical study.

  2008cited by this paper
• Hormesis in aging.

  2008cited by this paper
• Lifespan extension and increased pumping rate accompany pharyngeal muscle‐specific expression of nfi‐1 in C. elegans

  2008cited by this paper
• Regulating the Age-Related Oxidative Damage, Mitochondrial Integrity, and Antioxidative Enzyme Activity in Fischer 344 Rats by Supplementation of the Antioxidant Epigallocatechin-3-Gallate

  2008cited by this paper
• Silymarin, a Flavonoid from Milk Thistle (Silybum marianum L.), Inhibits UV‐induced Oxidative Stress Through Targeting Infiltrating CD11b+ Cells in Mouse Skin †

  2008cited by this paper
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  2007cited by this paper
• Attenuation of UVA-induced damage to human keratinocytes by silymarin.

  2007cited by this paper
• Silybin and silymarin--new and emerging applications in medicine.

  2007cited by this paper
• [Oxidative stress].

  2007cited by this paper
• Effects of the plant flavonoids silymarin and quercetin on arsenite-induced oxidative stress in CHO-K1 cells.

  2007cited by this paper
• Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts.

  2006cited by this paper
• Opposing Activities Protect Against Age-Onset Proteotoxicity

  2006cited by this paper
• The plasticity of aging: insights from long-lived mutants.

  2005cited by this paper
• Interactions of androgens, green tea catechins and the antiandrogen flutamide with the external glucose‐binding site of the human erythrocyte glucose transporter GLUT1

  2003cited by this paper
• Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?

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  2003cited by this paper
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  2002cited by this paper
• Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

  2000cited by this paper
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  2000cited by this paper
• Genetic pathways that regulate ageing in model organisms

  2000cited by this paper
• The daf‐2 gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression in Caenorhabditis elegans

  1999cited by this paper
• daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.

  1997cited by this paper
• daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.

  1997cited by this paper
• Oxidative stress hypothesis in Alzheimer's disease.

  1997cited by this paper
• Oxidative Stress, Caloric Restriction, and Aging

  1996cited by this paper
• Aggregation of Secreted Amyloid -Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture (*)

  1995cited by this paper
• Superoxide, hydrogen peroxide, and oxygen toxicity in two free-living nematode species.

  1983cited by this paper
• THE FREE RADICAL THEORY OF AGING: EFFECT OF AGE ON SERUM COPPER LEVELS.

  1965cited by this paper

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  2025cites this paper
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  2021cites this paper
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  2020cites this paper
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