Endothelin receptors cloned, endothelin converting enzyme characterized and pathophysiological roles for endothelin proposed.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  TIPS - Trends in Pharmacological Sciences

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/0165-6147(91)90492-BPMID 1850878
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulatory functions of the vascular endothelium.

  1990cited by this paper
• Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1.

  1990cited by this paper
• Conversion of big endothelin-1 by membrane-bound metalloendopeptidase in cultured bovine endothelial cells.

  1990cited by this paper
• Effect of endothelin-1 in man.

  1990cited by this paper
• Inhibition of biological actions of big endothelin-1 by phosphoramidon.

  1990cited by this paper
• Cloning and expression of a cDNA encoding an endothelin receptor

  1990cited by this paper
• Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

  1990cited by this paper
• Endothelin: isoforms, binding sites and possible implications in pathology.

  1990cited by this paper
• Molecular biology and biochemistry of the endothelins.

  1989cited by this paper
• Molecular biology and biochemistry of the endothelins.

  1989cited by this paper
• Specific inhibitors of endopeptidase 24.11 inhibit the metabolism of atrial natriuretic peptides in vitro and in vivo.

  1989cited by this paper
• Functional studies on endothelin catch up with molecular biology.

  1989cited by this paper
• The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

  1989cited by this paper
• A novel potent vasoconstrictor peptide produced by vascular endothelial cells

  1988cited by this paper
• Purification of a membrane-bound metalloendopeptidase from porcine kidney that degrades peptide hormones.

  1981cited by this paper

• Validation of phosphodiesterase isozymes as targets for pulmonary hypertension.

  2013cites this paper
• The role of the paracrine/autocrine mediator endothelin‐1 in regulation of cardiac contractility and growth

  2013cites this paper
• Themed section: endothelin

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• Endothelin-converting enzyme: the binding of metal ions.

  2009cites this paper
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  2005cites this paper
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• Endothelin-1 and endothelial damage in elderly patients.

  2002cites this paper
• Endothelin antagonists diminish postischemic microvascular incompetence and necrosis in the heart.

  2000cites this paper
• Endothelin and the Airway Epithelium

  1999cites this paper
• Nitric oxide limits the eicosanoid‐dependent bronchoconstriction and hypotension induced by endothelin‐1 in the guinea‐pig

  1999cites this paper
• Dynamic regulation of beta-adrenergic receptors by endothelin-1 in smooth-muscle cells.

  1998cites this paper
• Endothelin and the airway mucosa.

  1998cites this paper
• Pulmonary Actions of the Endothelins

  1998cites this paper
• Dynamic Regulation of β-Adrenergic Receptors by Endothelin-1 in Smooth-Muscle Cells

  1998cites this paper
• Inhibitors of endothelin

  1997cites this paper
• Endothelin-1 in arterial hypertension after cold pressor test.

  1997cites this paper
• Effect of cooling on vascular smooth muscle response to endothelin-1 in human and rat veins.

  1997cites this paper
• Endothelin Peptides in Brain Diseases

  1996cites this paper
• Characterization of endothelin receptors in the human umbilical artery and vein

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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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• Pharmacology of the Human Precursors of Endothelin: Role of Functional Receptors and Endothelin-Converting Enzyme

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  1994cites this paper
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  1993cites this paper
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  1993cites this paper
• Visualization of 125I-endothelin-1 binding sites in human placenta and umbilical vessels.

  1993cites this paper
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  1993cites this paper
• Characterization of endothelin receptors and localization of 125I-endothelin-1 binding sites in human umbilical artery.

  1993cites this paper
• Seminars in medicine of the Beth Israel Hospital, Boston. Platelet-endothelium interactions.

  1993cites this paper
• Endothelium-dependent modulation of responses to endothelin-I in human veins.

  1993cites this paper
• Incomplete inhibition of the pressor effects of endothelin‐1 and related peptides in the anaesthetized rat with BQ‐123 provides evidence for more than one vasoconstrictor receptor

  1993cites this paper
• Sarafotoxins and endothelins: evolution, structure and function.

  1993cites this paper
• Interaction of atrial natriuretic factor and endothelin-1 signals through receptor guanylate cyclase in pulmonary artery endothelial cells

  1993cites this paper
• Endothelins: circulating plasma levels and presence in other biologic fluids.

  1993cites this paper
• Stimulation of adult rat ventricular myocyte protein synthesis and phosphoinositide hydrolysis by the endothelins.

  1993cites this paper
• Mediation of endothelin‐1‐induced inhibition of platelet aggregation via the ETB receptor

  1993cites this paper
• A novel ETA‐receptor antagonist, FR 139317, inhibits endothelin‐induced contractions of guinea‐pig pulmonary arteries, but not trachea

  1993cites this paper
• Characterization of receptors for endothelins in the perfused arterial and venous mesenteric vasculatures of the rat

  1993cites this paper
• [125I]-endothelin-1 binding to vasa vasorum and regions of neovascularization in human and porcine blood vessels: a possible role for endothelin in intimal hyperplasia and atherosclerosis.

  1993cites this paper
• Modulators of calcium and potassium channels: their effects on endothelin-1 binding to cardiac membranes.

  1993cites this paper
• Drugs acting on the intracellular signalling system

  1993cites this paper
• The endothelin family of peptides: local hormones with diverse roles in health and disease?

  1993cites this paper
• Endothelin: progress in pharmacology and physiology.

  1993cites this paper
• Endothelin‐1 modulates vascular smooth muscle structure and vasomotion: Implications in cardiovascular pathology

  1993cites this paper
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  1992cites this paper
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  1992cites this paper
• WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. II. Biological characterization and pharmacological characterization of WS-7338 B.

  1992cites this paper
• Analysis of responses to endothelins in isolated porcine blood vessels by using a novel endothelin antagonist, BQ-153.

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  1992cites this paper
• Distribution of 125I-endothelin-1,-2,-3 binding sites in mammalian kidneys.

  1992cites this paper
• WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. III. Structures of WS-7338 A, B, C and D and total synthesis of WS-7338 B.

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  1992cites this paper
• Endothelin mechanisms in the central nervous system: A target for drug development

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• [Molecular pharmacology of endothelin in the cardiovascular system].

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• Plasma Endothelin in Chronic Heart Failure

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• WS009 A and B, new endothelin receptor antagonists isolated from Streptomyces sp. no. 89009. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

  1992cites this paper
• Endothelin: a long-acting local constrictor hormone.

  1992cites this paper
• New Directions in Cardiovascular System Control.

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• Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor.

  1992cites this paper
• Cerebrovascular and coronary effects of endothelin-1 in the goat.

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• The generation of big-endothelin (1-22) (endothelin-valine) from big-endothelin in the soluble fraction of porcine lung.

  1992cites this paper
• WS009 A and B, new endothelin receptor antagonists isolated from Streptomyces sp. no. 89009. II. Biological characterization and pharmacological characterization of WS009 A and B.

  1992cites this paper
• Inactivation of endothelin I by deamidase (lysosomal protective protein).

  1992cites this paper
• Raised plasma concentrations of endothelin-1 and -3 in marmosets with acute aortic stenosis: no relation to the renin-angiotensin system.

  1992cites this paper
• [Plasma endothelin is increased in heart failure--no effect of a short infusion of atrial natriuretic factor].

  1991cites this paper
• Autoradiographic evidence for endothelin receptors on astrocytes in cultures of rat cerebellum, brainstem and spinal cord.

  1991cites this paper
• Endothelin-1: a potent vasoactive peptide.

  1991cites this paper
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  1990cites this paper