[Adenovirus infection in immunocompromised patients].

Human adenoviruses belong to the Adenoviridae family and they are divided into seven species, including 56 types. Adenoviruses are common opportunistic pathogens that are rarely associated with clinical symptoms in immunocompetent patients. However, they are emerging pathogens causing morbidity and mortality in recipients of hematopoietic stem cell and solid organ transplants, HIV infected patients and patients with primary immune deficiencies. Clinical presentation ranges from asymptomatic viraemia to respiratory and gastrointestinal disease, haemorrhagic cystitis and severe disseminated illness. There is currently no formally approved therapy for the treatment of adenovirus infections. This article presents current knowledge about adenoviruses, their pathogenicity and information about available methods to diagnose and treat adenoviral infections.

• Publication year

  2013

• Venue

  Postępy Higieny i Medycyny Doświadczalnej

• Publication date

  2013-09-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.5604/17322693.1066199PMID 24088540
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Improved real-time PCR assay for detection and quantification of all 54 known types of human adenoviruses in clinical samples

  2012cited by this paper
• Human adenovirus infection in patients subjected to allogeneic hematopoietic stem cell transplantation--a three-year single center study.

  2012cited by this paper
• Disseminated Adenovirus Disease in Immunocompromised Patient Successfully Treated with Oral Ribavirin: A Case Report

  2011cited by this paper
• Computational analysis and identification of an emergent human adenovirus pathogen implicated in a respiratory fatality.

  2011cited by this paper
• PCR diagnostics and monitoring of adenoviral infections in hematopoietic stem cell transplantation recipients

  2010cited by this paper
• Adenovirus Infections in Pediatric Small Bowel Transplant Recipients

  2010cited by this paper
• Hematuria due to adenoviral infection in bone marrow transplant recipients.

  2010cited by this paper
• Computational Analysis Identifies Human Adenovirus Type 55 as a Re-Emergent Acute Respiratory Disease Pathogen

  2009cited by this paper
• Evidence of Molecular Evolution Driven by Recombination Events Influencing Tropism in a Novel Human Adenovirus that Causes Epidemic Keratoconjunctivitis

  2009cited by this paper
• Recent Advances in Diagnostic Microbiology

  2009cited by this paper
• Spread of Epidemic Keratoconjunctivitis Due to a Novel Serotype of Human Adenovirus in Japan

  2009cited by this paper
• Adenovirus infections in solid organ transplant recipients

  2009cited by this paper
• Adenoviruses in Immunocompromised Hosts

  2008influential reference
• A myocarditis outbreak with fatal cases associated with adenovirus subgenera C among children from Havana City in 2005.

  2008cited by this paper
• Adenoviral Infection - Pathomechanism and Diagnostics

  2008cited by this paper
• Treatment of adenovirus disease in stem cell transplant recipients with cidofovir.

  2007influential reference
• Adenovirus infection after allogeneic stem cell transplantation

  2007cited by this paper
• Outcome of Hematopoietic Stem Cell Transplantation in Severe Combined Immune Deficiency With Central Nervous System Viral Infection

  2007cited by this paper
• X-Linked Agammaglobulinemia: Report on a United States Registry of 201 Patients

  2006cited by this paper
• Adenovirus infections in transplant recipients.

  2006cited by this paper
• Adenoviral infections in hematopoietic stem cell transplantation.

  2006influential reference
• Detection and sequence-based typing of human adenoviruses using sensitive universal primer sets for the hexon gene

  2006cited by this paper
• Adenovirus fulminant hepatic failure: disseminated adenovirus disease after unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia.

  2006cited by this paper
• Antiviral therapy for adenovirus infections.

  2006cited by this paper
• The power of real-time PCR.

  2005cited by this paper
• Electron microscopy as a reliable tool for rapid and conventional detection of enteric viral agents: a five-year experience report.

  2005cited by this paper
• Mechanisms of action of ribavirin against distinct viruses

  2005cited by this paper
• Effect of ribavirin on the plasma viral DNA load in patients with disseminating adenovirus infection.

  2004cited by this paper
• Hemorrhagic adenovirus cystitis after renal transplantation.

  2004cited by this paper
• Hemorrhagic cystitis following allogeneic hematopoietic cell transplantation.

  2003influential reference
• Adenovirus: an increasingly important pathogen in paediatric bone marrow transplant patients.

  2003cited by this paper
• Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease.

  2003cited by this paper
• The impact of adenovirus infection on the immunocompromised host

  2003influential reference
• Real-time PCR in virology.

  2002cited by this paper
• Intravenous ribavirin treatment for severe adenovirus disease in immunocompromised children.

  2002cited by this paper
• A syndrome of transient encephalopathy associated with adenovirus infection.

  2001cited by this paper
• Adult adenovirus infections: loss of orphaned vaccines precipitates military respiratory disease epidemics. For the Adenovirus Surveillance Group.

  2000cited by this paper
• Isolation and characterization of adenovirus 5 from the brain of an infant with fatal cerebral edema.

  2000cited by this paper
• Adenoviruses from Human Immunodeficiency Virus-Infected Individuals, Including Two Strains That Represent New Candidate Serotypes Ad50 and Ad51 of Species B1 and D, Respectively

  1999cited by this paper
• Adenovirus infections in hematopoietic stem cell transplant recipients.

  1999cited by this paper
• Adenovirus infections in human immunodeficiency virus-positive patients: clinical features and molecular epidemiology.

  1995cited by this paper
• Adenovirus pulmonary infections identified by PCR and in situ hybridisation in bone marrow transplant recipients.

  1994cited by this paper
• Aplastic anaemia complicating adenovirus infection in DiGeorge syndrome

  1988cited by this paper

• Adenovirus pneumonia in an immunocompetent patient : A case report

  2024cites this paper
• Immunological Activities of Isoprinosine Inhibition on Viral Infections Inhuman

  2019cites this paper
• Sequence typing of human adenoviruses isolated from Polish patients subjected to allogeneic hematopoietic stem cell transplantation – a single center experience

  2018cites this paper
• Primary murine neurons as in vitro model for studying neuroinfections caused by human adenoviruses.

  2016cites this paper
• A review on antiviral activity of the Himalayan medicinal plants traditionally used to treat bronchitis and related symptoms

  2016cites this paper
• Methods to Mitigate Immune Responses to Adenoviral Vectors

  2016cites this paper
• An infection of human adenovirus 31 affects the differentiation of preadipocytes into fat cells, its metabolic profile and fat accumulation

  2016cites this paper