Current strategies to generate mature human induced pluripotent stem cells derived cholangiocytes and future applications

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Organogenesis

• Publication date

  2017-01-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/15476278.2016.1278133PMID 28055309PMCID PMC5323032
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2016cited by this paper
• Hepatocyte-like cells derived from induced pluripotent stem cells

  2016cited by this paper
• Emerging roles of Notch signaling in liver disease

  2015cited by this paper
• The Cholangiopathies.

  2015influential reference
• Animal Models in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis

  2015cited by this paper
• Animal Models of Primary Biliary Cirrhosis

  2015cited by this paper
• Directed differentiation of cholangiocytes from human pluripotent stem cells

  2015cited by this paper
• Development and Characterization of Human Induced Pluripotent Stem Cell-Derived Cholangiocytes

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• MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment

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• Bile Acids in Physiology, Pathology and Pharmacology.

  2015influential reference
• Involvement of PSMD10, CDK4, and Tumor Suppressors in Development of Intrahepatic Cholangiocarcinoma of Syrian Golden Hamsters Induced by Clonorchis sinensis and N-Nitrosodimethylamine

  2015cited by this paper
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• Orchestrating liver development

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• Genetic Contributors and Modifiers of Biliary Atresia

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  2015cited by this paper
• Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease.

  2015cited by this paper
• Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells

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• Human induced pluripotent stem cells in hepatology: beyond the proof of concept.

  2014cited by this paper
• Intrasplenic transplanted adult rat isolated hepatocyte fraction but not cholangiocytes forms bile canaliculi.

  2014influential reference
• Physiology of cholangiocytes.

  2013cited by this paper
• Distinct gene expression signatures in human embryonic stem cells differentiated towards definitive endoderm at single-cell level.

  2013cited by this paper
• Generation of Multipotent Foregut Stem Cells from Human Pluripotent Stem Cells

  2013cited by this paper
• Neonatal liver physiology.

  2013cited by this paper
• The Zebrafish as a Model to Study Polycystic Liver Disease

  2013cited by this paper
• Bile formation and secretion.

  2013cited by this paper
• Cocarcinogenic Effects of Intrahepatic Bile Acid Accumulation in Cholangiocarcinoma Development

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• Rapid generation of mature hepatocyte‐like cells from human induced pluripotent stem cells by an efficient three‐step protocol

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• Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells

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• α1- and α5-containing Laminins Regulate the Development of Bile Ducts via β1 Integrin Signals*

  2012cited by this paper
• Biliary differentiation and bile duct morphogenesis in development and disease.

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• TGR5 in the Biliary Tree

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  2011cited by this paper
• Intramuscular transplantation of engineered hepatic tissue constructs corrects acute and chronic liver failure in mice.

  2010cited by this paper
• Notch signaling regulates formation of the three‐dimensional architecture of intrahepatic bile ducts in mice

  2010cited by this paper
• Generation of murine hepatic lineage cells from induced pluripotent stem cells.

  2010cited by this paper
• Highly efficient generation of human hepatocyte–like cells from induced pluripotent stem cells

  2010cited by this paper
• Exploring the genetic architecture of neonatal hyperbilirubinemia.

  2010cited by this paper
• Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development

  2010cited by this paper
• Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells

  2009cited by this paper
• Generation of functional human hepatic endoderm from human induced pluripotent stem cells

  2009cited by this paper
• Differentiation and transplantation of human embryonic stem cell-derived hepatocytes.

  2009cited by this paper
• Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells.

  2009cited by this paper
• Foxa1 and Foxa2 regulate bile duct development in mice.

  2009cited by this paper
• Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies.

  2009cited by this paper
• Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9.

  2009cited by this paper
• Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation

  2009cited by this paper
• Liver‐specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice

  2008cited by this paper
• Embryology of Extra‐ and Intrahepatic Bile Ducts, the Ductal plate

  2008cited by this paper
• Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

  2008cited by this paper
• β‐Catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development

  2008cited by this paper
• Prospero‐related homeobox 1 and liver receptor homolog 1 coordinately regulate long‐term proliferation of murine fetal hepatoblasts

  2008cited by this paper
• Hepatocyte transplantation-biology and application.

  2007cited by this paper
• Thinking outside the cell: the role of extracellular adenosine triphosphate in bile formation.

  2007cited by this paper
• Direct Differentiation of Human Embryonic Stem Cells to Hepatocyte-like Cells Exhibiting Functional Activities

  2007cited by this paper
• Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture.

  2007cited by this paper
• Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell–derived hepatocytes

  2006cited by this paper
• Immunolocalization of extracellular matrix components and integrins during mouse liver development

  2004cited by this paper
• The role of notch signaling in the development of intrahepatic bile ducts.

  2004cited by this paper
• Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells

  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
• A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency.

  2002cited by this paper
• The onecut transcription factor HNF6 is required for normal development of the biliary tract.

  2002cited by this paper
• Neonatal hyperbilirubinemia.

  2001cited by this paper
• Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes

  2001cited by this paper
• Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.

  1996cited by this paper
• The development of the intrahepatic bile ducts in man: A keratin‐immunohistochemical study

  1988cited by this paper
• Hepatic bile acid metabolism during early development revealed from the analysis of human fetal gallbladder bile.

  1988cited by this paper
• Bile acid biosynthesis during development: hydroxylation of C27-sterols in human fetal liver.

  1986cited by this paper
• Ontogenesis of taurocholate transport by rat ileal brush border membrane vesicles.

  1985cited by this paper
• Diversity of Bile Acids in the Fetus and Newborn Infant

  1983cited by this paper
• Bile salt metabolism in the first year of life.

  1982cited by this paper
• Physiologic cholestasis: elevation of the primary serum bile acid concentrations in normal infants.

  1981cited by this paper
• Postnatal development: coordination of feeding, digestion, and metabolism.

  1981cited by this paper
• Taurocholate pool size and distribution in the fetal rat.

  1979cited by this paper
• Influence of bile acids on bile canalicular membrane morphology and the lobular gradient in canalicular size.

  1978cited by this paper
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  1969cited by this paper

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