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Congenital Toxoplasmosis: In Vivo Impact of Toxoplasma gondii Infection on Myogenesis and Neurogenesis

Alessandra F Gomes,H. S. Barbosa

Published 2017 in Unknown venue

ABSTRACT

Congenital toxoplasmosis (TC) from Toxoplasma gondii positive mother to child transmis‐ sion results in fetal death, abortion, or infantile neurologic and neurocognitive deficits as well as chorioretinitis. This study aims to analyze the morphological changes in brain and skeletal muscle cells of Swiss mouse embryos during experimental congenital toxo‐ plasmosis. Swiss mice, before mating, were gavage inoculation infected with approxi‐ mately 25 or 50 cysts of ME‐49 strain T. gondii . Eighteen day postcoitus maternal and embryonic muscle and brain samples were collected and processed for histopathologi‐ cal analysis. The muscle tissue from embryos of infected mothers, in comparison with healthy muscle myofibers, exhibited discontinuous and shorter myofibrils, more interfi ‐ brillar space and immature cells with fewer stained and poorly defined striated profiles. These in vivo findings might be related to an adhesion protein decrease, observed in vitro , where myogenesis was completely affected during Toxoplasma infection. The neurogen‐ esis was severely affected with irregularly arranged cells, reduced cell density, and a significant intercellular space increase. The brain tissue presented ischemia, cell death, necrosis, and thrombi, increasing according to the degree of the acute infection, which compromised the neurogenesis, thereby justifying brain size decrease in these embryos.

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