A cellular reporter assay to monitor insulin receptor kinase activity based on STAT 5-dependent luciferase gene expression.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Analytical Biochemistry

• Publication date

  1999-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/ABIO.1999.4345PMID 10585749
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Discovery of a small molecule insulin mimetic with antidiabetic activity in mice.

  1999cited by this paper
• Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

  1999cited by this paper
• Insulin receptor-associated protein tyrosine phosphatase(s): Role in insulin action

  1998cited by this paper
• Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance

  1998cited by this paper
• Signalling pathways of an insulin-mimetic phosphoinositolglycan-peptide in muscle and adipose tissue.

  1998cited by this paper
• TNF inhibits insulin induced STAT5 activation in differentiated mouse muscle cells pmi28

  1998cited by this paper
• Protein phosphatase-1 and insulin action

  1998cited by this paper
• Stimulation of the intracellular portion of the human insulin receptor by the antidiabetic drug metformin.

  1998cited by this paper
• Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis.

  1998cited by this paper
• In NIH-3T3 Fibroblasts, Insulin Receptor Interaction with Specific Protein Kinase C Isoforms Controls Receptor Intracellular Routing*

  1998cited by this paper
• Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue

  1998cited by this paper
• Induction of Jak/STAT signaling by activation of the type 1 TNF receptor.

  1998cited by this paper
• The IRS-signalling system: A network of docking proteins that mediate insulin action

  1998cited by this paper
• Glucosamine-induced Insulin Resistance in 3T3-L1 Adipocytes Is Caused by Depletion of Intracellular ATP*

  1998cited by this paper
• An assay method for evaluating chemical selectivity of agonists for insulin signaling pathways based on agonist-induced phosphorylation of a target peptide.

  1998cited by this paper
• Identification of Stat 5B as a substrate of the insulin receptor.

  1997cited by this paper
• Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor.

  1997cited by this paper
• Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking

  1997cited by this paper
• Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins.

  1997cited by this paper
• Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription

  1997cited by this paper
• Stat5 is a physiological substrate of the insulin receptor.

  1997cited by this paper
• Protein kinase C isoforms β 1 and β 2 inhibit the tyrosine kinase activity of the insulin receptor

  1997cited by this paper
• Functional interactions between Stat5 and the glucocorticoid receptor

  1996cited by this paper
• Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes.

  1996cited by this paper
• Insulin signal transduction and the IRS proteins.

  1996cited by this paper
• SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates.

  1996cited by this paper
• Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus

  1995cited by this paper
• Interleukin‐3, granulocyte‐macrophage colony stimulating factor and interleukin‐5 transduce signals through two STAT5 homologs.

  1995cited by this paper
• Involvement of Janus kinases in the insulin signaling pathway.

  1995cited by this paper
• A nonradioactive assay for the insulin receptor tyrosine kinase: use in monitoring receptor kinase activity after activation of overexpressed protein kinase C alpha and high glucose treatment.

  1995cited by this paper
• Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase.

  1994cited by this paper
• Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

  1994cited by this paper
• The insulin signaling system.

  1994cited by this paper
• The IRS-1 signaling system.

  1994cited by this paper
• YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase.

  1992cited by this paper
• Defects of insulin's signal transduction in old rat livers.

  1992cited by this paper
• A rationale for the design of an inhibitor of tyrosyl kinase.

  1990cited by this paper
• Phosphorylation of synthetic insulin receptor peptides by the insulin receptor kinase and evidence that the preferred sequence containing Tyr-1150 is phosphorylated in vivo.

  1986cited by this paper
• Use of tyrosine-containing polymers to characterize the substrate specificity of insulin and other hormone-stimulated tyrosine kinases.

  1985cited by this paper
• Printed in U.S.A. Copyright © 1997 by The Endocrine Society Specific Inhibition of Insulin-Like Growth Factor-1 and Insulin Receptor Tyrosine Kinase Activity and Biological Function by Tyrphostins

  year unknowncited by this paper

• Screening chimeric GAA variants in preclinical study results in hematopoietic stem cell gene therapy candidate vectors for Pompe disease

  2022cites this paper
• Fatty acids may influence insulin dynamics through modulation of albumin‐Zn2+ interactions

  2021cites this paper
• Orientation‐specific signalling by thrombopoietin receptor dimers

  2011cites this paper
• A cell-based screening method for specifically detecting kinase activity

  2008cites this paper
• A Robust, Target-Driven, Cell-Based Assay for Checkpoint Kinase 1 Inhibitors

  2007cites this paper
• Dual Enzyme-Linked Immunosorbent Assay System for Detection of Endogenous Kinase Activities of Mitogen- and Stress-Activated Protein Kinase-1/2

  2007cites this paper
• Modulation and Lack of Cross‐Talk between Signal Transducer and Activator of Transcription 5 and Suppressor of Cytokine Signaling‐3 in Insulin and Growth Hormone Signaling in 3T3‐L1 Adipocytes

  2006cites this paper
• Novel early target genes of PTHrP in chondrocytes

  2006influential citation
• An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor.

  2006cites this paper
• The role of PTHrP in chondrocyte differentiation

  2006influential citation
• Novel early target genes of parathyroid hormone-related peptide in chondrocytes.

  2006cites this paper
• Differential STAT5 Signaling by Ligand-dependent and Constitutively Active Cytokine Receptors*

  2005cites this paper
• Multiplex mRNA assay using electrophoretic tags for high-throughput gene expression analysis.

  2004cites this paper
• Optimized reporter gene assays based on a synthetic multifunctional promoter and a secreted luciferase.

  2003cites this paper
• Growth hormone, but not insulin, activates STAT5 proteins in adipocytes in vitro and in vivo.

  2003cites this paper
• Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer.

  2003cites this paper
• The tyrphostin AG1024 accelerates the degradation of phosphorylated forms of retinoblastoma protein (pRb) and restores pRb tumor suppressive function in melanoma cells.

  2003cites this paper
• Multiplexed Screening Assay for mRNA Combining Nuclease Protection with Luminescent Array Detection

  2002cites this paper
• Cellular platforms for HTS: three case studies.

  2002cites this paper
• Simultaneous overexpression of GH and STAT5b genes inhibits the STAT5 signalling pathway in tilapia (Oreochromis niloticus) embryos.

  2002cites this paper
• Receptor Screens for Small Molecule Agonist and Antagonist Discovery

  2001cites this paper
• Discovery of cytokine mimics using cell-based systems.

  2000cites this paper