CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation

A. N. Kousholt,Kasper Fugger,Saskia Hoffmann,Brian D. Larsen,T. Menzel,A. Sartori,C. Sørensen

Published 2012 in Journal of Cell Biology

ABSTRACT

CtIP-dependent DNA end resection, which was previously thought to be necessary for CHK1 kinase activation and subsequent DNA damage checkpoint induction, is in fact only required for sustained checkpoint signaling.

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