Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Molecular Cancer Research

• Publication date

  2017-01-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1541-7786.MCR-16-0305PMID 28137761
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Sequence Analysis

  2020cited by this paper
• EBV-associated Burkitt lymphoma in Taiwan is not age-related

  2016cited by this paper
• Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study

  2016influential reference
• Gold nano-particles (AuNPs) carrying anti-EBV-miR-BART7-3p inhibit growth of EBV-positive nasopharyngeal carcinoma

  2015cited by this paper
• PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity.

  2015cited by this paper
• The tumor virus landscape of AIDS-related lymphomas.

  2015cited by this paper
• The presence of Epstein-Barr virus significantly impacts the transcriptional profile in immunodeficiency-associated Burkitt lymphoma

  2015cited by this paper
• Distinct Viral and Mutational Spectrum of Endemic Burkitt Lymphoma

  2015cited by this paper
• The Epstein Barr-encoded BART-6-3p microRNA affects regulation of cell growth and immuno response in Burkitt lymphoma

  2014cited by this paper
• svaseq: removing batch effects and other unwanted noise from sequencing data

  2014cited by this paper
• Interleukin 1 receptor-associated kinase 1 (IRAK1) mutation is a common, essential driver for Kaposi sarcoma herpesvirus lymphoma

  2014cited by this paper
• The genomic landscape of nasopharyngeal carcinoma

  2014cited by this paper
• Comprehensive profiling of Epstein-Barr virus-encoded miRNA species associated with specific latency types in tumor cells

  2013cited by this paper
• Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

  2013cited by this paper
• New insights into pre-BCR and BCR signalling with relevance to B cell malignancies

  2013cited by this paper
• Landscape of genomic alterations in cervical carcinomas

  2013cited by this paper
• Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing.

  2013cited by this paper
• The Epstein-Barr Virus (EBV)-Induced Tumor Suppressor MicroRNA MiR-34a Is Growth Promoting in EBV-Infected B Cells

  2012cited by this paper
• Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection

  2012cited by this paper
• Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing

  2012cited by this paper
• MSH6 Mutations are Frequent in Hereditary Nonpolyposis Colorectal Cancer Families With Normal pMSH6 Expression as Detected by Immunohistochemistry

  2012cited by this paper
• Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches.

  2012cited by this paper
• The genetic landscape of mutations in Burkitt lymphoma

  2012cited by this paper
• Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

  2012cited by this paper
• Molecular signatures database (MSigDB) 3.0

  2011cited by this paper
• RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

  2011cited by this paper
• The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.

  2010cited by this paper
• Elevated anti-Zta IgG levels and EBV viral load are associated with site of tumor presentation in endemic Burkitt's lymphoma patients: a case control study

  2010cited by this paper
• Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes.

  2010cited by this paper
• The c-MYC-AP4-p21 cascade

  2009cited by this paper
• The PI3K/Akt pathway as a target in the treatment of hematologic malignancies.

  2009cited by this paper
• Children with endemic Burkitt lymphoma are deficient in EBNA1‐specific IFN‐γ T cell responses

  2009cited by this paper
• DDX3 DEAD-Box RNA Helicase Is Required for Hepatitis C Virus RNA Replication

  2007cited by this paper
• The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma.

  2007cited by this paper
• Germinal Center B Cell-Like (GCB) and Activated B Cell-Like (ABC) Type of Diffuse Large B Cell Lymphoma (DLBCL): Analysis of Molecular Predictors, Signatures, Cell Cycle State and Patient Survival

  2007cited by this paper
• Burkitt's lymphoma: clinicopathologic features and differential diagnosis.

  2006influential reference
• Impact of tumor Epstein-Barr virus status on presenting features and outcome in age-defined subgroups of patients with classic Hodgkin lymphoma: a population-based study.

  2005cited by this paper
• Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response

  2005cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005cited by this paper
• Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

  2005cited by this paper
• Modulation of the Cell Growth Regulator mTOR by Epstein-Barr Virus-Encoded LMP2A

  2005cited by this paper
• Regulation of the Expression of Caspase-9 by the Transcription Factor Activator Protein-4 in Glucocorticoid-induced Apoptosis*

  2005cited by this paper
• Clinical characteristics of Burkitt's lymphoma seen in Kenyan patients.

  2004cited by this paper
• Gender and age-related differences in Burkitt lymphoma--epidemiological and clinical data from The Netherlands.

  2004cited by this paper
• Early stage of Epstein-Barr virus lytic infection leading to the "starry sky" pattern formation in endemic Burkitt lymphoma.

  2004cited by this paper
• Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility

  2003cited by this paper
• Long term survival of children with Burkitt lymphoma in Malawi after cyclophosphamide monotherapy.

  2003cited by this paper
• Lymphoma‐ and leukemia‐associated chromosomal translocations in healthy individuals

  2003cited by this paper
• The role of the proteasome activator PA28 in MHC class I antigen processing.

  2002cited by this paper
• Epstein–Barr virus–associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2

  2002cited by this paper
• High prevalence of Epstein-Barr virus type 2 among homosexual men is caused by sexual transmission.

  2000cited by this paper
• HIV-associated malignant lymphomas in Kenya (Equatorial Africa)

  1998cited by this paper
• Expression of endothelial nitric oxide synthase in human and rabbit gastrointestinal smooth muscle cells.

  1998cited by this paper
• Epidemiology of Infection with Epstein-Barr Virus Types 1 and 2: Lessons from the Study of a T-Cell-Immunocompromised Hemophilic Cohort

  1998cited by this paper
• Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon.

  1996cited by this paper
• Distinction between Epstein-Barr virus type A (EBNA 2A) and type B (EBNA 2B) isolates extends to the EBNA 3 family of nuclear proteins

  1989cited by this paper
• Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation.

  1989cited by this paper
• New type B isolates of Epstein-Barr virus from Burkitt's lymphoma and from normal individuals in endemic areas.

  1987cited by this paper
• Differences in B cell growth phenotype reflect novel patterns of Epstein‐Barr virus latent gene expression in Burkitt's lymphoma cells.

  1987cited by this paper
• Influence of the Epstein-Barr virus nuclear antigen EBNA 2 on the growth phenotype of virus-transformed B cells

  1987cited by this paper
• Geographical prevalence of two types of Epstein-Barr virus.

  1986cited by this paper
• U2 region of Epstein-Barr virus DNA may encode Epstein-Barr nuclear antigen 2.

  1984cited by this paper
• MALIGNANT LYMPHOMA IN AFRICAN CHILDREN

  1961cited by this paper

• Molecular mechanisms of Epstein-Barr Virus in the pathogenesis of lymphomas and new opportunities for precision medicine

  2026cites this paper
• The ancestral haplotype of P2RX5 yields a B-cell surface marker and a multi-lineage immunotherapy target

  2026cites this paper
• PLCG2 across human disease: genetic variants, signaling mechanisms, and clinical implications

  2026cites this paper
• Novel RAD50 variants lead to Nijmegen Breakage Syndrome-like disorder and unplanned recombinant human growth hormone treatment response.

  2026cites this paper
• Burkitt Lymphoma-A Guide to Biological Features, Diagnosis and Differential Diagnosis.

  2026cites this paper
• EBV Type 1 versus Type 2: A determinant of NK cell anti-tumor activity in Burkitt lymphoma

  2026cites this paper
• Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts

  2025cites this paper
• Comparison of nanopore with illumina whole genome assemblies of the Epstein-Barr virus in Burkitt lymphoma

  2025cites this paper
• Clinical and molecular variations in Burkitt lymphoma

  2025cites this paper
• Inhibition of EgRad50 leads to impaired DNA repair in Echinococcus granulosus sensu stricto.

  2025cites this paper
• Incorporation of Epstein–Barr viral variation implicates significance of Latent Membrane Protein 1 in survival prediction and prognostic subgrouping in Burkitt lymphoma

  2025influential citation
• Comparison of Nanopore with Illumina Whole Genome Assemblies of the Epstein-Barr Virus in Burkitt Lymphoma

  2025cites this paper
• Transcriptional regulation of gene modules in Epstein-Barr virus

  2025cites this paper
• Incorporation of Epstein-Barr viral variation implicates significance of LMP1 in survival prediction and prognostic subgrouping in Burkitt lymphoma

  2024influential citation
• Epstein–Barr Virus Latent Membrane Protein 2A (LMP2A) Enhances ATP Production in B Cell Tumors through mTOR and HIF-1α

  2024cites this paper
• Update: The molecular spectrum of virus-associated high-grade B-cell non-Hodgkin lymphomas.

  2024cites this paper
• The Functional Interaction Between Epstein–Barr Virus and MYC in the Pathogenesis of Burkitt Lymphoma

  2024cites this paper
• The ‘Oma’s of the Gammas—Cancerogenesis by γ-Herpesviruses

  2024cites this paper
• Burkitt Lymphoma.

  2024cites this paper
• A Diagnostic Approach in Large B-Cell Lymphomas According to the Fifth World Health Organization and International Consensus Classifications and a Practical Algorithm in Routine Practice

  2024cites this paper
• SOX11 in EBV-negative Burkitt lymphoma.

  2024cites this paper
• METTL3 regulates M6A methylation-modified EBV-pri-miR-BART3-3p to promote NK/T cell lymphoma growth.

  2024cites this paper
• Genomic landscape of virus-associated cancers

  2023cites this paper
• Viral and host factors drive a type 1 Epstein–Barr virus spontaneous lytic phenotype

  2023cites this paper
• Understanding human health through metatranscriptomics.

  2023cites this paper
• Cytogenomics of B-cell non-Hodgkin lymphomas: The "old" meets the "new".

  2023cites this paper
• MYC directly transactivates CR2/CD21, the receptor of the Epstein–Barr virus, enhancing the viral infection of Burkitt lymphoma cells

  2023cites this paper
• Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in Kenyan children with endemic Burkitt lymphoma

  2023cites this paper
• From the archives of MD Anderson Cancer Center: Sporadic Burkitt lymphoma with a complex karyotype and SOX11 expression.

  2023cites this paper
• RNA-seq research landscape in Africa: systematic review reveals disparities and opportunities

  2023cites this paper
• The variant landscape and function of DDX3X in cancer and neurodevelopmental disorders.

  2023cites this paper
• Aggressive non-Hodgkin lymphoma in the pediatric and young adult population; diagnostic and molecular pearls of wisdom.

  2023cites this paper
• Worldwide Prevalence of Epstein–Barr Virus in Patients with Burkitt Lymphoma: A Systematic Review and Meta-Analysis

  2023influential citation
• The RNA helicase DDX3 and its role in c-MYC driven germinal center-derived B-cell lymphoma

  2023cites this paper
• Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies

  2023influential citation
• Silencing proline-rich coiled-coil 2C inhibit the proliferation and metastasis of liver cancer cells

  2023cites this paper
• Alternative splicing of its 5’-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

  2023cites this paper
• Construction of a DNA damage repair gene signature for predicting prognosis and immune response in breast cancer

  2023cites this paper
• SWI/SNF complexes in hematological malignancies: biological implications and therapeutic opportunities

  2023cites this paper
• Genes associated with diagnosis and prognosis of Burkitt lymphoma

  2022cites this paper
• Epstein Barr virus genomes reveal population structure and type 1 Epstein Barr virus genomes reveal population structure and type 1 association with endemic Burkitt lymphoma [preprint] association with endemic Burkitt lymphoma [preprint]

  2022cites this paper
• Epstein-Barr Virus Genomes Reveal Population Structure and Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma Type 1 Association with Endemic Burkitt Lymphoma

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• Poorly cytotoxic terminally differentiated CD56(neg)CD16(pos) Poorly cytotoxic terminally differentiated CD56(neg)CD16(pos) NK cells accumulate in Kenyan children with Burkitt lymphomas NK cells accumulate in Kenyan children with Burkitt lymphomas

  2022cites this paper
• Latent membrane proteins from EBV differentially target cellular pathways to accelerate MYC-induced lymphomagenesis

  2022cites this paper
• The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

  2022cites this paper
• Association of PD-1/PD-L1 expression and Epstein-–Barr virus infection in patients with invasive breast cancer

  2022cites this paper
• EBV-associated diseases: Current therapeutics and emerging technologies

  2022cites this paper
• Functional Implications of Epstein-Barr Virus Lytic Genes in Carcinogenesis

  2022cites this paper
• A comparison of the International Consensus and 5th World Health Organization classifications of mature B-cell lymphomas

  2022cites this paper
• Inhibitor of DNA binding/differentiation proteins as IDs for Pancreatic cancer: Role in pancreatic cancer initiation, development and prognosis.

  2022cites this paper
• Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis

  2022cites this paper
• Journal Pre-proof Genetic errors of immunity distinguish pediatric non-malignant lymphoproliferative disorders

  2022cites this paper
• Burkitt Lymphomas Evolve to Escape Dependencies on Epstein-Barr Virus

  2021influential citation
• Reframing Burkitt lymphoma: virology not epidemiology defines clinical variants

  2021cites this paper
• Genomic landscape of Epstein–Barr virus-positive extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue

  2021cites this paper
• Interplay between IL-10, IFN-γ, IL-17A and PD-1 Expressing EBNA1-Specific CD4+ and CD8+ T Cell Responses in the Etiologic Pathway to Endemic Burkitt Lymphoma

  2021cites this paper
• Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma

  2021cites this paper
• Epstein–Barr virus status of sporadic Burkitt lymphoma is associated with patient age and mutational features

  2021cites this paper
• Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells

  2021cites this paper
• Genetic errors of immunity distinguish pediatric non-malignant lymphoproliferative disorders.

  2021cites this paper
• Malaria and Cancer: a critical review on the established associations and new perspectives

  2021cites this paper
• The role of EBV in haematolymphoid proliferations: emerging concepts relevant to diagnosis and treatment

  2021cites this paper
• Frequent co-reactivation of Epstein–Barr virus in patients with cytomegalovirus viremia under immunosuppressive therapy and/or chemotherapy

  2020cites this paper
• Cancer Omics in Africa: Present and Prospects

  2020cites this paper
• A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex

  2020influential citation
• Burkitt Lymphoma as Fourth Neoplasia in a Patient Affected by Cowden Syndrome with a Novel PTEN Germline Pathogenic Variant

  2020cites this paper
• Burkitt lymphoma-related TCF3 mutations alter TCF3 alternative splicing by disrupting hnRNPH1 binding

  2020cites this paper
• Epstein–Barr virus nuclear antigen 2 extensively rewires the human chromatin landscape at autoimmune risk loci

  2020cites this paper
• Noncatalytic Bruton's tyrosine kinase activates PLCγ2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells

  2020influential citation
• Kaposi Sarcoma-associated herpesvirus infection and endemic Burkitt's lymphoma.

  2020cites this paper
• Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma

  2019cites this paper
• Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

  2019cites this paper
• Pathogenesis of B-Cell Lymphoma

  2019cites this paper
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  2019cites this paper
• Sensitive detection of EBV microRNAs across cancer spectrum reveals association with decreased survival in adult acute myelocytic leukemia

  2019cites this paper
• MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment

  2019cites this paper
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  2019influential citation
• Epstein-Barr Virus Type 2 Infects T Cells and Induces B Cell Lymphomagenesis in Humanized Mice

  2018cites this paper
• Deciphering the roles of FOXO1 in human neoplasms

  2018cites this paper
• The Investigation of Sex Specific DNA Regions in Morelia spilota imbricata

  2018cites this paper
• Functional characterization of phospholipase C-γ2 mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder

  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
• Human and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma

  2017cites this paper
• Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma

  2017cites this paper
• EBV and Apoptosis: The Viral Master Regulator of Cell Fate?

  2017cites this paper
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  2017cites this paper