Does p16ink4a expression increase with the number of cell doublings in normal and malignant lymphocytes?

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis

• Publication date

  2007-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.LEUKRES.2007.03.021PMID 17475325
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Autolysosomes accumulate during in vitro CD8+ T-lymphocyte aging and may participate in induced death sensitization of senescent cells.

  2004cited by this paper
• Introduction of p16INK4a inhibits telomerase activity through transcriptional suppression of human telomerase reverse transcriptase expression in human gliomas.

  2004cited by this paper
• p16(INK4a) immunocytochemical analysis is an independent prognostic factor in childhood acute lymphoblastic leukemia.

  2002cited by this paper
• p16INK4a immunocytochemical analysis is an independent prognostic factor in childhood acute lymphoblastic leukemia

  2002cited by this paper
• Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

  2001cited by this paper
• Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors.

  2001cited by this paper
• Overexpression of the p16 Cell Cycle Inhibitor in Breast Cancer is Associated with a More Malignant Phenotype

  2001cited by this paper
• Induction of pRb Degradation by the Human Papillomavirus Type 16 E7 Protein Is Essential To Efficiently Overcome p16INK4a-Imposed G1 Cell Cycle Arrest

  2001cited by this paper
• INK4a gene expression and methylation in primary breast cancer: overexpression of p16INK4a messenger RNA is a marker of poor prognosis.

  2000cited by this paper
• Concurrence of replicative senescence and elevated expression of p16(INK4A) with subculture-induced but not calcium-induced differentiation in normal human oral keratinocytes.

  2000cited by this paper
• Enhanced expression of p16ink4a is associated with a poor prognosis in childhood acute lymphoblastic leukemia

  1999cited by this paper
• The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

  1999cited by this paper
• Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues.

  1999cited by this paper
• Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence

  1998cited by this paper
• Retinoblastoma and p16 proteins in mammary carcinoma: Their relationship to cyclin D1 and histopathological parameters

  1998cited by this paper
• Features of replicative senescence induced by direct addition of antennapedia‐p16INK4A fusion protein to human diploid fibroblasts

  1998cited by this paper
• Glucocorticoids induce G1 as well as S-phase lengthening in normal human stimulated lymphocytes: differential effects on cell cycle regulatory proteins.

  1998cited by this paper
• Systemic effect of intrathecal methotrexate during the initial phase of treatment of childhood acute lymphoblastic leukemia. The European Organization for Research and Treatment of Cancer Children's Leukemia Cooperative Group.

  1997cited by this paper
• Cyclin D1 and p16INK4A are preferentially expressed in immature and mature myeloma cells, respectively

  1997cited by this paper
• Prognostic implications of cyclins (D1, E, A), cyclin‐dependent kinases (CDK2, CDK4) and tumor‐suppressor genes (pRb, p16INK4A) in childhood acute lymphoblastic leukemia

  1997cited by this paper
• Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status

  1997cited by this paper
• Changes in telomerase activity and telomere length during human T lymphocyte senescence.

  1997cited by this paper
• Homozygous deletion of the p16/MTS1 gene in pediatric acute lymphoblastic leukemia is associated with unfavorable clinical outcome.

  1997cited by this paper
• Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

  1996cited by this paper
• Role of the INK4a locus in tumor suppression and cell mortality.

  1996cited by this paper
• Telomerase regulation during entry into the cell cycle in normal human T cells.

  1996cited by this paper
• Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.

  1996cited by this paper
• Differential expression of cell proliferation regulatory proteins in B‐ and T‐lineage acute lymphoblastic leukaemias

  1996cited by this paper
• Inhibitors of mammalian G1 cyclin-dependent kinases.

  1995cited by this paper
• Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

  1995cited by this paper
• 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

  1995cited by this paper
• Expression of the cyclin‐dependent kinase inhibitor p16 during the ongoing cell cycle

  1995cited by this paper
• CDK1 is a marker of proliferation in human lymphoid cells

  1995cited by this paper
• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995cited by this paper
• Lack of cyclin D‐Cdk complexes in Rb‐negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.

  1995cited by this paper
• Determination of lymphocyte division by flow cytometry.

  1994cited by this paper
• Specific association of human telomerase activity with immortal cells and cancer.

  1994cited by this paper
• Leukaemic peripheral blood plasma and bone marrow plasma: comparison of influence on lymphocyte proliferation

  1994cited by this paper
• Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.

  1994influential reference
• D-type cyclin-dependent kinase activity in mammalian cells

  1994cited by this paper
• Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

  1994cited by this paper
• Monitoring mRNA expression by polymerase chain reaction: the "primer-dropping" method.

  1994cited by this paper
• Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias.

  1994cited by this paper
• Adult acute lymphoblastic leukemia: a multicentric randomized trial testing bone marrow transplantation as postremission therapy. The French Group on Therapy for Adult Acute Lymphoblastic Leukemia.

  1993cited by this paper
• 老化ヒト二倍体線維芽細胞におけるG1サイクリン調節の変化 不活性サイクリンE‐Cdk2及びサイクリンD1‐Cdk2複合体

  1993cited by this paper
• Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes.

  1993cited by this paper
• Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts.

  1990cited by this paper
• Telomeres shorten during ageing of human fibroblasts

  1990cited by this paper
• Rate and Time of Dna Synthesis of Human Leukaemic Blasts In Bone Marrow and Peripheral Blood

  1986cited by this paper
• Cell-cycle, protein content, and nuclear size in acute myeloid leukemia.

  1985cited by this paper
• DNA and RNA determination in 111 cases of childhood acute lymphoblastic leukaemia (ALL) by flow cytometry: correlation of FAB classification with DNA stemline and proliferation

  1985cited by this paper
• A methodological study of E-rosette formation using AET-treated sheep red blood cells.

  1979cited by this paper
• THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.

  1965cited by this paper
• Proliferation and Maturation Defect in Acute Leukæmia Cells

  1964cited by this paper

• mammalian senescent nurse cell provides Trichinella spp. muscle larvae with cell growth inhibitory capacity.

  2026cites this paper
• Upregulation of p16INK4A in Peripheral White Blood Cells as a Novel Screening Marker for Colorectal Carcinoma

  2022cites this paper
• The ibrutinib B-cell proliferation inhibition is potentiated in vitro by dexamethasone: Application to chronic lymphocytic leukemia.

  2016cites this paper
• Co-localization of EBV and Expression of P16- Cyclin-Dependent Kinase inhibitor Protein in Tissues from Patients with Non- Hodgkin's Lymphoma

  2016cites this paper
• Rapamycin safeguards lymphocytes from DNA damage accumulation in vivo.

  2016cites this paper
• The p16(INK4A)/pRb pathway and telomerase activity define a subgroup of Ph+ adult Acute Lymphoblastic Leukemia associated with inferior outcome.

  2015cites this paper
• Loss of P16 Protein Expression and Its Association with Epstein-Barr Virus LMP-1 Expression in Hodgkin's Lymphoma

  2013influential citation
• Loss of P 16 / INK 4 A Protein Expression is a Common Abnormality in Hodgkin ’ s Lymphoma

  2012cites this paper
• Cell cycle regulatory molecular profiles of pediatric T-cell lymphoblastic leukemia and lymphoma

  2012cites this paper
• Tumor Suppressor Gene p16/INK4A/CDKN2A and Its Role in Cell Cycle Exit, Differentiation, and Determination of Cell Fate

  2012cites this paper
• The Cyclin-Dependent Kinase Inhibitor and Tumor Suppressor Locus p16/INK4Ap14ARF and Regulation of the Transition Into and Out of the Cell Cycle

  2011cites this paper
• Loss of P16/INK4A Protein Expression is a Common Abnormality in Hodgkin's Lymphoma

  2010cites this paper
• Transcriptional Activation of hTERT, the Human Telomerase Reverse Transcriptase, by Nuclear Factor of Activated T Cells*

  2009cites this paper
• Telomere uncapping during in vitro T‐lymphocyte senescence

  2009cites this paper
• Prognostic value of miR-16 expression in childhood acute lymphoblastic leukemia relationships to normal and malignant lymphocyte proliferation.

  2009cites this paper