Toll-like receptor 4 plays significant roles during allergic rhinitis.

Allergic rhinitis is a nasal hypersensitivity and allergic disease which leads to inflammation of nasal mucosa. Previous investigations revealed that innate immune receptors play a key role in the pathogenesis of inflammatory diseases including allergic diseases. Toll-like receptors (TLRs), which are important innate immune receptors, play crucial roles in the recognition of foreign antigens, including allergens, and subsequently for the induction of immune responses such as inflammation. There are several controversial reports regarding the roles of TLR4 in the pathogenesis of allergic rhinitis. This review presents current information regarding the roles of TLR4 in the pathogenesis of allergic rhinitis and the plausible mechanisms which lead to the expression and function of TLR4 in this disease.

• Publication year

  2015

• Venue

  Allergologia et Immunopathologia

• Publication date

  2015-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.aller.2014.04.006PMID 25097025
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expanding the use of monoclonal antibody therapy of cancer by using ionising radiation to upregulate antibody targets

  2014cited by this paper
• Monoclonal Antibody Therapy and Renal Transplantation: Focus on Adverse Effects

  2014cited by this paper
• Prevalence of Atopy and Respiratory Allergic Diseases in the Elderly SAPALDIA Population

  2013cited by this paper
• Compléments : Distinct TLR-mediated pathways regulate house dust mite–induced allergic disease in the upper and lower airways

  2013cited by this paper
• Helminth therapy (worms) for allergic rhinitis.

  2012cited by this paper
• Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and susceptibility to asthma and allergic rhinitis: a case-control analysis.

  2012cited by this paper
• Review paper Allergic diseases – current state of knowledge

  2012cited by this paper
• An anti-IgE monoclonal antibody that binds to IgE on CD23 but not on high-affinity IgE.Fc receptors.

  2012cited by this paper
• Rhinology: Diseases of the Nose, Sinuses, and Skull Base

  2012cited by this paper
• Systemic Up-Regulation of TLR4 Causes Lipopolysaccharide-Induced Augmentation of Nasal Cytokine Release in Allergic Rhinitis

  2012cited by this paper
• TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis

  2012cited by this paper
• Advances in mechanisms of asthma, allergy, and immunology in 2011.

  2012cited by this paper
• Toll-like receptors: role of inflammation and commensal bacteria.

  2011cited by this paper
• Allergic rhinitis.

  2011cited by this paper
• Associations of allergic sensitization and clinical phenotypes with innate immune response genes polymorphisms are modified by house dust mite allergen exposure

  2011cited by this paper
• [Activation of Rho-kinase pathway is involved in angiotensin II-induced contraction of human airway smooth muscle cells].

  2011cited by this paper
• Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways.

  2011cited by this paper
• Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists

  2011cited by this paper
• Lack of Association Between Chemokine Receptor 5 (CCR5) &dgr;32 Mutation and Pathogenesis of Asthma in Iranian Patients

  2011cited by this paper
• Identification of polymorphisms in the Toll-like receptor gene and the association with allergic rhinitis

  2010cited by this paper
• Allergic rhinitis: evidence-based practice.

  2010cited by this paper
• Allergic rhinitis : review

  2010cited by this paper
• Endogenous ligands of TLR2 and TLR4: agonists or assistants?

  2010cited by this paper
• Advances in mechanisms of asthma, allergy, and immunology in 2008.

  2009cited by this paper
• Pathophysiology of itching and sneezing in allergic rhinitis.

  2009cited by this paper
• Common variants of the TLR9 gene influence the clinical course of HBV infection.

  2009cited by this paper
• Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein: Toll-Like Receptor 4– and Spleen Tyrosine Kinase–Dependent Activation of NADPH Oxidase 2

  2009cited by this paper
• LPS/TLR4 signal transduction pathway.

  2008cited by this paper
• Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function.

  2007cited by this paper
• Differential Regulation of Toll-Like Receptor 4 Gene Expression in Renal Cells by Angiotensin II: Dependency on AP1 and PU.1 Transcriptional Sites

  2007cited by this paper
• TLR3 signaling in a hepatoma cell line is skewed towards apoptosis

  2007cited by this paper
• Reduction of TLR2 gene expression in allergic and nonallergic rhinitis.

  2007cited by this paper
• TLR4 agonists as immunomodulatory agents.

  2006cited by this paper
• Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling.

  2006cited by this paper
• TLR4 agonists as immunomodulatory agents

  2006cited by this paper
• Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis

  2005cited by this paper
• Absence of the toll-like receptor 4 gene polymorphisms Asp299Gly and Thr399Ile in Singaporean Chinese

  2005cited by this paper
• Toll-like receptor 2 as a major gene for asthma in children of European farmers.

  2004cited by this paper
• A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children.

  2004cited by this paper
• Enhancement of antigen-specific immunity via the TLR4 ligands MPL™ adjuvant and Ribi.529

  2003cited by this paper
• Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

  2003cited by this paper
• LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

  2003cited by this paper
• Rhinitis , sinusitis , and upper airway disease Childhood allergic rhinitis , traffic-related air pollution , and variability in the GSTP 1 , TNF , TLR 2 , and TLR 4 genes : Results from the TAG Study

  year unknowncited by this paper

• Pollution-Induced Allergy Skews Metabolism Toward Obesity-A Conceptual Review.

  2026cites this paper
• miR-6089 Alleviates Inflammation and Cell Apoptosis Through Modulating the TLR4 Pathway in Mite-Sensitized Allergic Rhinitis

  2025cites this paper
• Alleviation of Ovalbumin-Allergic Reactions in Mice by Eucommia ulmoides Polysaccharides via Modulation of Intestinal Microbiota

  2025cites this paper
• Toll-like receptors and Streptococcus mutans: An updated review article.

  2024cites this paper
• Genetically predicted N-methylhydroxyproline levels mediate the association between naive CD8+ T cells and allergic rhinitis: a mediation Mendelian randomization study

  2024cites this paper
• Deciphering the Systemic Impact of Herbal Medicines on Allergic Rhinitis: A Network Pharmacological Approach

  2024influential citation
• Chemical modification by peroxynitrite enhances TLR4 activation of the grass pollen allergen Phl p 5

  2023cites this paper
• Key genes and immune infiltration in chronic spontaneous urticaria: a study of bioinformatics and systems biology

  2023cites this paper
• Shexiang Tongxin Dropping Pretreated Mesenchymal Stem Cells-derived Exosomes Attenuate Cardiac Ischemia/Reperfusion Injury by Modulating miR-182-5p and miR-199a-3p-mediated Inflammatory Responses

  2023cites this paper
• International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

  2023cites this paper
• Allergic rhinitis in BALB/c mice is associated with behavioral and hippocampus changes and neuroinflammation via the TLR4/ NF-κB signaling pathway.

  2022cites this paper
• A review of recent advances in exosomes and allergic rhinitis

  2022cites this paper
• Breastfeeding increases the expression of TLR4, TNF-α, CCL2, and CCL3 in the prepuce tissue of neonates.

  2022cites this paper
• Unified Airway Disease: A Contemporary Review and Introduction.

  2022cites this paper
• Research progress on the role of toll-like receptor 4 in allergic rhinitis

  2022cites this paper
• Cow Farmers’ Homes Host More Diverse Airborne Bacterial Communities Than Pig Farmers’ Homes and Suburban Homes

  2022cites this paper
• Innate and adaptive immunity in allergic airway disease

  2021cites this paper
• Breastfeeding by Human Milk Significantly Increases the Expression of TLR4, TNF-α, CCL2, and CCL3 in the Prepuce Tissue of Neonates

  2021cites this paper
• Mechanisms and molecular targets of the Yu-Ping-Feng powder for allergic rhinitis, based on network pharmacology

  2021cites this paper
• MicroRNA-182-5p relieves murine allergic rhinitis via TLR4/NF-κB pathway

  2020cites this paper
• MiR-146a mimic attenuates murine allergic rhinitis by downregulating TLR4/TRAF6/NF-κB pathway.

  2019cites this paper
• Inhibition of TLR4 inhibits allergic responses in murine allergic rhinitis by regulating the NF-κB pathway.

  2019cites this paper
• Inhibition of TLR 4 inhibits allergic responses in murine allergic rhinitis by regulating the NF ‐ κ B pathway

  2019cites this paper
• Understanding allergic multimorbidity within the non-eosinophilic interactome

  2019cites this paper
• Modulatory Effect of Ginger Aqueous Extract on Imidacloprid Induced Hepatotoxicity in Rats

  2019cites this paper
• 国际过敏与鼻科学共识声明 : 变应性鼻炎

  2018cites this paper
• Vitamin D and toll like receptors

  2018cites this paper
• Sessile Innate Immune Cells

  2018cites this paper
• Toll-Like Receptor 4 as an Immune Receptor Against Mycobacterium tuberculosis: A Systematic Review.

  2018cites this paper
• The Effect of Alcoholic Extract of Ginger on Apoptosis and Inflammation of Germ Cells in Streptozotocin-Induced Diabetic Rats

  2018cites this paper
• International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis

  2018cites this paper
• The roles of toll like receptor 3, 7 and 8 in allergic rhinitis pathogenesis.

  2018cites this paper
• Chronoinflammaging in Alzheimer; A systematic review on the roles of toll like receptor 2

  2017cites this paper
• Toll like receptor 4 and hepatocellular carcinoma; A systematic review

  2017cites this paper
• Toll like receptor 4: an important molecule in recognition and induction of appropriate immune responses against Chlamydia infection.

  2017cites this paper
• The Possible Role of Toll-Like Receptor 4 in the Pathology of Stroke.

  2017cites this paper
• The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview

  2016cites this paper
• Nonselective chemokine levels in nasal secretions of patients with perennial nonallergic and allergic rhinitis

  2016cites this paper
• Controversial roles played by toll like receptor 4 in urinary bladder cancer; A systematic review.

  2016cites this paper
• The Possible Role of Toll-Like Receptor 4 in the Pathology of Stroke

  2016cites this paper
• Atopy in children with the enthesitis-related arthritis (ERA) subtype of juvenile idiopathic arthritis is associated with a worse outcome

  2015cites this paper