Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Obesity Reviews

• Publication date

  2017-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/obr.12523PMID 28335087
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2015influential reference
• FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

  2015cited by this paper
• Apple Pomace Extract Improves Endurance in Exercise Performance by Increasing Strength and Weight of Skeletal Muscle

  2015cited by this paper
• Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training

  2015cited by this paper
• A natural solution for obesity: Bioactives for the prevention and treatment of weight gain. A review

  2015cited by this paper
• Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.

  2015cited by this paper
• The hunger genes: pathways to obesity.

  2015cited by this paper
• Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

  2015cited by this paper
• Low and high doses of ursolic acid ameliorate experimental autoimmune myasthenia gravis through different pathways.

  2015cited by this paper
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  2015cited by this paper
• Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

  2015cited by this paper
• Ursolic acid increases energy expenditure through enhancing free fatty acid uptake and β-oxidation via an UCP3/AMPK-dependent pathway in skeletal muscle.

  2015influential reference
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  2014cited by this paper
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  2014influential reference
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  2014cited by this paper
• A Brief Review of Critical Processes in Exercise-Induced Muscular Hypertrophy

  2014cited by this paper
• Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis?

  2014cited by this paper
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  2014influential reference
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  2014cited by this paper
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013influential reference
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  2012influential reference
• Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.

  2012cited by this paper
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  2011influential reference
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  2009cited by this paper
• [Effects of dietary bioactive compounds on obesity induced inflammation].

  2009cited by this paper
• Ursolic acid: an anti- and pro-inflammatory triterpenoid.

  2008influential reference
• Sarcopenic obesity: definition, cause and consequences

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2005cited by this paper
• Invited review: Aging and sarcopenia.

  2003cited by this paper
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  2003influential reference
• Minireview: the glucagon-like peptides.

  2001cited by this paper
• Central nervous system control of food intake

  2000cited by this paper
• Towards a molecular understanding of adaptive thermogenesis

  2000influential reference
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  2000cited by this paper

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