BB0323 function is essential for Borrelia burgdorferi virulence and persistence through tick-rodent transmission cycle.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Infectious Diseases

• Publication date

  2009-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1086/605846PMID 19754308PMCID PMC2896499
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis

  2008cited by this paper
• A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks.

  2008cited by this paper
• LysM, a widely distributed protein motif for binding to (peptido)glycans

  2008cited by this paper
• Prevention of tick-borne diseases.

  2008cited by this paper
• A Tightly Regulated Surface Protein of Borrelia burgdorferi Is Not Essential to the Mouse-Tick Infectious Cycle

  2008cited by this paper
• Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection

  2008cited by this paper
• The novel Cladosporium fulvum lysin motif effector Ecp6 is a virulence factor with orthologues in other fungal species

  2008cited by this paper
• Borrelia burgdorferi Complement Regulator-Acquiring Surface Protein 2 Does Not Contribute to Complement Resistance or Host Infectivity

  2008cited by this paper
• Both Decorin-Binding Proteins A and B Are Critical for the Overall Virulence of Borrelia burgdorferi

  2008cited by this paper
• Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle

  2007cited by this paper
• The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi

  2007cited by this paper
• Role of Outer Surface Protein D in the Borrelia burgdorferi Life Cycle

  2007cited by this paper
• The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks

  2007cited by this paper
• Inactivation of the fibronectin‐binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi

  2006cited by this paper
• Antibody-Mediated Disease Remission in the Mouse Model of Lyme Borreliosis

  2006cited by this paper
• Comparative proteome analysis of subcellular fractions from Borrelia burgdorferi by NEPHGE and IPG

  2006cited by this paper
• Serologic Proteome Analysis of Borrelia burgdorferi Membrane-Associated Proteins

  2006cited by this paper
• Borrelia burgdorferi Lacking BBK32, a Fibronectin-Binding Protein, Retains Full Pathogenicity

  2006cited by this paper
• bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector.

  2005cited by this paper
• Relative Contributions of Innate and Acquired Host Responses to Bacterial Control and Arthritis Development in Lyme Disease

  2005cited by this paper
• The Multifunctional Staphylococcus aureus Autolysin Aaa Mediates Adherence to Immobilized Fibrinogen and Fibronectin

  2005cited by this paper
• The burgeoning molecular genetics of the Lyme disease spirochaete

  2005cited by this paper
• Pleiotropic Effects of Inactivating a Carboxyl-Terminal Protease, CtpA, in Borrelia burgdorferi

  2004cited by this paper
• TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi.

  2004cited by this paper
• Essential Role for OspA/B in the Life Cycle of the Lyme Disease Spirochete

  2004cited by this paper
• Elucidation of Lyme arthritis

  2004cited by this paper
• Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals.

  2004cited by this paper
• Genome-Wide Transposon Mutagenesis of Borrelia burgdorferi for Identification of Phenotypic Mutants

  2004influential reference
• Experimental Assessment of the Roles of Linear Plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the Infectious Cycle

  2004cited by this paper
• Infectious Cycle Analysis of a Borrelia burgdorferi Mutant Defective in Transport of Chitobiose, a Tick Cuticle Component

  2004cited by this paper
• OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands.

  2004cited by this paper
• Combined Effects of Blood and Temperature Shift on Borrelia burgdorferi Gene Expression as Determined by Whole Genome DNA Array

  2004cited by this paper
• aadA Confers Streptomycin Resistance in Borrelia burgdorferi

  2003cited by this paper
• Expression of a luxS Gene Is Not Required for Borrelia burgdorferi Infection of Mice via Needle Inoculation

  2003cited by this paper
• Global Analysis of Borrelia burgdorferi Genes Regulated by Mammalian Host-Specific Signals

  2003cited by this paper
• Prediction of lipoprotein signal peptides in Gram‐negative bacteria

  2003cited by this paper
• A plasmid‐encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host

  2003cited by this paper
• Clonal Polymorphism of Borrelia burgdorferi Strain B31 MI: Implications for Mutagenesis in an Infectious Strain Background

  2002cited by this paper
• Borrelia burgdorferi gene expression profiling with membrane-based arrays.

  2002cited by this paper
• DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete

  2002cited by this paper
• Molecular Adaptation of Borrelia burgdorferi in the Murine Host

  2002cited by this paper
• Temporal regulation of outer surface proteins of the Lyme-disease spirochaete Borrelia burgdorferi.

  2001cited by this paper
• Borrelia burgdorferi periplasmic flagella have both skeletal and motility functions.

  2000cited by this paper
• A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi

  2000cited by this paper
• Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi

  1997cited by this paper
• Perspectives Series: Host/Pathogen Interactions Arthropod- and Host-specific Gene Expression by Borrelia burgdorferi

  1997cited by this paper
• Virulent strain associated outer membrane proteins of Borrelia burgdorferi.

  1995cited by this paper
• Chronic Lyme borreliosis in the laboratory mouse.

  1993cited by this paper

• Targeting of interaction between BB0323-BB0238 informs new paradigms in Lyme disease therapeutics

  2026cites this paper
• Borrelial phosphomannose isomerase as a cell surface localized protein that retains enzymatic activity and promotes host-pathogen interaction

  2025influential citation
• Borrelia burgdorferi serine protease HtrA is a pleiotropic regulator of stress response, motility, flagellar hemostasis, and infectivity

  2025cites this paper
• Borrelia burgdorferi radiosensitivity and Mn antioxidant content: antigenic preservation and pathobiology

  2024cites this paper
• Borrelia burgdorferi BB0346 is an Essential, Structurally Variant LolA Homolog that is Primarily Required for Homeostatic Localization of Periplasmic Lipoproteins

  2024cites this paper
• New BB0108, BB0126, BB0298, BB0323, and BB0689 Chromosomally Encoded Recombinant Proteins of Borrelia burgdorferi sensu lato for Serodiagnosis of Lyme Disease

  2024cites this paper
• A unique borrelial protein facilitates microbial immune evasion

  2023influential citation
• A chemosensory-like histidine kinase is dispensable for chemotaxis in vitro but regulates the virulence of Borrelia burgdorferi through modulating the stability of RpoS

  2023cites this paper
• In silico epitope prediction of Borrelia burgdorferi sensu lato antigens for the detection of specific antibodies.

  2023cites this paper
• Structural Analysis of the Outer Membrane Lipoprotein BBA14 (OrfD) and the Corresponding Paralogous Gene Family 143 (PFam143) from Borrelia burgdorferi

  2022cites this paper
• Controlled Proteolysis of an Essential Virulence Determinant Dictates Infectivity of Lyme Disease Pathogens

  2022cites this paper
• Characterization of the Flagellar Collar Reveals Structural Plasticity Essential for Spirochete Motility

  2021cites this paper
• Endogenous and Borrowed Proteolytic Activity in the Borrelia

  2021cites this paper
• Borrelia burgdorferi Surface Exposed GroEL Is a Multifunctional Protein

  2021cites this paper
• Structural analysis of Borrelia burgdorferi periplasmic lipoprotein BB0365 involved in Lyme disease infection

  2020cites this paper
• Genetic Manipulation of Borrelia.

  2020cites this paper
• Lyme Disease Pathogenesis.

  2020cites this paper
• LYME DISEASE AND RELAPSING FEVER SPIROCHETES

  2020cites this paper
• LYME DISEASE AND RELAPSING FEVER SPIROCHETES

  2020cites this paper
• Assessing the Contribution of an HtrA Family Serine Protease During Borrelia turicatae Mammalian Infection

  2019cites this paper
• Crystal structure of the N-terminal domain of the major virulence factor BB0323 from the Lyme disease agent Borrelia burgdorferi.

  2019cites this paper
• Borrelia burgdorferi protein interactions critical for microbial persistence in mammals

  2018cites this paper
• Fluorescent Proteins, Promoters, and Selectable Markers for Applications in the Lyme Disease Spirochete Borrelia burgdorferi

  2018cites this paper
• Identification of Lyme borreliae proteins promoting vertebrate host blood-specific spirochete survival in Ixodes scapularis nymphs using artificial feeding chambers.

  2018cites this paper
• Artificial Infection of Ticks with Borrelia burgdorferi Using a Microinjection Method and Their Detection In Vivo Using Quantitative PCR Targeting flaB RNA.

  2018cites this paper
• Fluorescent Proteins, Promoters, and Selectable Markers for Applications in the Lyme Disease Spirochete <named-content content-type='genus-species'>Borrelia burgdorferi</named-content>

  2018cites this paper
• HtrA of Borrelia burgdorferi Leads to Decreased Swarm Motility and Decreased Production of Pyruvate

  2018cites this paper
• Comprehensive Spatial Analysis of the Borrelia burgdorferi Lipoproteome Reveals a Compartmentalization Bias toward the Bacterial Surface

  2017cites this paper
• A protein-protein interaction dictates Borrelial infectivity

  2017cites this paper
• The Borrelia burgdorferi CheY3 response regulator is essential for chemotaxis and completion of its natural infection cycle

  2016cites this paper
• Motility and chemotaxis in the Lyme disease spirochete Borrelia burgdorferi : role in pathogenesis

  2016influential citation
• Borrelia burgdorferi HtrA: evidence for twofold proteolysis of outer membrane protein p66

  2016cites this paper
• Borrelia burgdorferi CheD Promotes Various Functions in Chemotaxis and the Pathogenic Life Cycle of the Spirochete

  2016influential citation
• HtrA, a Temperature- and Stationary Phase-Activated Protease Involved in Maturation of a Key Microbial Virulence Determinant, Facilitates Borrelia burgdorferi Infection in Mammalian Hosts

  2016influential citation
• Borrelia burgdorferi CheY2 Is Dispensable for Chemotaxis or Motility but Crucial for the Infectious Life Cycle of the Spirochete

  2016cites this paper
• Cyclic di-GMP Modulates Gene Expression in Lyme Disease Spirochetes at the Tick-Mammal Interface To Promote Spirochete Survival during the Blood Meal and Tick-to-Mammal Transmission

  2015cites this paper
• BB0323 and novel virulence determinant BB0238: Borrelia burgdorferi proteins that interact with and stabilize each other and are critical for infectivity.

  2015influential citation
• The lipid raft proteome of Borrelia burgdorferi

  2015cites this paper
• BB0238, a Presumed Tetratricopeptide Repeat-Containing Protein, Is Required during Borrelia burgdorferi Mammalian Infection

  2014cites this paper
• Assessment of the potential contribution of the highly conserved C-terminal motif (C10) of Borrelia burgdorferi outer surface protein C in transmission and infectivity.

  2014cites this paper
• Insights into the biology of Borrelia burgdorferi gained through the application of molecular genetics.

  2014cites this paper
• Use of an Endogenous Plasmid Locus for Stable in trans Complementation in Borrelia burgdorferi

  2014cites this paper
• A Chitin Deacetylase-Like Protein Is a Predominant Constituent of Tick Peritrophic Membrane That Influences the Persistence of Lyme Disease Pathogens within the Vector

  2013cites this paper
• Borrelia burgdorferi HtrA may promote dissemination and irritation

  2013cites this paper
• Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector.

  2013cites this paper
• Proteolysis of BB0323 results in two polypeptides that impact physiologic and infectious phenotypes in Borrelia burgdorferi

  2013influential citation
• Novel microbial virulence factor triggers murine lyme arthritis.

  2013influential citation
• Motility Is Crucial for the Infectious Life Cycle of Borrelia burgdorferi

  2013cites this paper
• The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hosts.

  2013cites this paper
• Borrelia burgdorferi Needs Chemotaxis To Establish Infection in Mammals and To Accomplish Its Enzootic Cycle

  2012cites this paper
• Intruders below the Radar: Molecular Pathogenesis of Bartonella spp

  2012cites this paper
• A Novel Gene Inactivation System Reveals Altered Periplasmic Flagellar Orientation in a Borrelia burgdorferi fliL Mutant

  2011influential citation
• SURFACE LOCALIZATION DETERMINANTS OF BORRELIA BURGDORFERI LIPOPROTEINS

  2011cites this paper
• Tick proteins in Borrelia transmission and tick feeding: t(r)ick or treat?

  2011cites this paper
• Lyme borreliosis vaccination: the facts, the challenge, the future.

  2011cites this paper
• The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host

  2011cites this paper
• Borrelia burgdorferi BBA52 is a potential target for transmission blocking Lyme disease vaccine.

  2011cites this paper
• Analysis of the Borrelia burgdorferi Cyclic-di-GMP-Binding Protein PlzA Reveals a Role in Motility and Virulence

  2011cites this paper
• Characterization of multiprotein complexes of the Borrelia burgdorferi outer membrane vesicles.

  2011cites this paper
• Methods for rapid transfer and localization of lyme disease pathogens within the tick gut.

  2011cites this paper
• Functional Analysis of the Borrelia burgdorferi bba64 Gene Product in Murine Infection via Tick Infestation

  2011cites this paper
• Analysis of the HD-GYP Domain Cyclic Dimeric GMP Phosphodiesterase Reveals a Role in Motility and the Enzootic Life Cycle of Borrelia burgdorferi

  2011cites this paper
• Characterization of Unique Regions of Borrelia burgdorferi Surface-Located Membrane Protein 1

  2010cites this paper
• CHARACTERIZATION OF BORRELIA BURGDORFERI GENE PRODUCTS CRITICAL FOR PATHOGEN PERSISTENCE AND TRANSMISSION

  2010cites this paper
• BBA52 facilitates Borrelia burgdorferi transmission from feeding ticks to murine hosts.

  2010cites this paper