Dihydroartemisinin up‐regulates VE‐cadherin expression in human renal glomerular endothelial cells

The antimalarial agent dihydroartemisinin (DHA) has been shown to be anti‐inflammatory. In this study, we found that DHA increased the expression of the junctional protein vascular endothelial (VE)‐cadherin in human renal glomerular endothelial cells. In addition, DHA inhibited TGF‐β RI‐Smad2/3 signalling and its downstream effectors SNAIL and SLUG, which repress VE‐cadherin gene transcription. Correspondingly, DHA decreased the binding of SNAIL and SLUG to the VE‐cadherin promoter. Together, our results suggest an effect of DHA in regulating glomerular permeability by elevation of VE‐cadherin expression.

• Publication year

  2017

• Venue

  Journal of Cellular and Molecular Medicine

• Publication date

  2017-11-29

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/jcmm.13448PMID 29193726PMCID 5824371
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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