Proteolytic cleavage of urokinase-type plasminogen activator by stromelysin-1 (MMP-3).

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Biochemistry

• Publication date

  1998-05-19

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI9728708PMID 9585535
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Receptor-independent Role of Urokinase-Type Plasminogen Activator in Pericellular Plasmin and Matrix Metalloproteinase Proteolysis during Vascular Wound Healing in Mice

  1998cited by this paper
• ER-to-Golgi transport visualized in living cells

  1997cited by this paper
• Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

  1997cited by this paper
• Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1

  1997cited by this paper
• X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.

  1996cited by this paper
• Generation and characterization of urokinase receptor-deficient mice.

  1996cited by this paper
• Degradation of cross-linked fibrin by matrix metalloproteinase 3 (stromelysin 1): hydrolysis of the gamma Gly 404-Ala 405 peptide bond.

  1996cited by this paper
• Matrix metalloproteinases and their inhibitors.

  1995cited by this paper
• Proteolytic remodeling of extracellular matrix.

  1995cited by this paper
• Mechanisms of physiological fibrinolysis.

  1995cited by this paper
• Stromelysin‐1: Three‐dimensional structure of the inhibited catalytic domain and of the C‐truncated proenzyme

  1995cited by this paper
• The NMR structure of the inhibited catalytic domain of human stromelysin–1

  1994cited by this paper
• Characterization of the binding of urokinase-type plasminogen activator (u-PA) to plasminogen, to plasminogen-activator inhibitor-1 and to the u-PA receptor.

  1994cited by this paper
• Effect of linoleic acid hydroperoxide on production of matrix metalloproteinases by human aortic endothelial and smooth muscle cells.

  1993cited by this paper
• Substrate specificity of the human matrix metalloproteinase stromelysin and the development of continuous fluorometric assays.

  1992cited by this paper
• The matrix metalloproteinase pump-1 catalyzes formation of low molecular weight (pro)urokinase in cultures of normal human kidney cells.

  1992cited by this paper
• A novel coumarin‐labelled peptide for sensitive continuous assays of the matrix metalloproteinases

  1992cited by this paper
• Matrix metalloproteinases and their inhibitors in connective tissue remodeling

  1991cited by this paper
• Stepwise activation mechanisms of the precursors of matrix metalloproteinases 1 (tissue collagenase) and 3 (stromelysin).

  1991cited by this paper
• Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization.

  1991cited by this paper
• Metalloproteinases and their inhibitors in matrix remodeling.

  1990cited by this paper
• Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin).

  1990cited by this paper
• Substrate specificity of human fibroblast stromelysin. Hydrolysis of substance P and its analogues.

  1989cited by this paper
• Biochemical and thrombolytic properties of a low molecular weight form (comprising Leu144 through Leu411) of recombinant single-chain urokinase-type plasminogen activator.

  1988cited by this paper
• Characterization of recombinant human single chain urokinase-type plasminogen activator mutants produced by site-specific mutagenesis of lysine 158.

  1987cited by this paper
• The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.

  1987cited by this paper
• Purification and characterization of a novel low molecular weight form of single-chain urokinase-type plasminogen activator.

  1986cited by this paper
• Characterization and fibrin-binding properties of different molecular forms of pro-urokinase from a monkey kidney cell culture.

  1986cited by this paper
• Comparative kinetic analysis of the activation of human plasminogen by natural and recombinant single-chain urokinase-type plasminogen activator.

  1986cited by this paper
• The primary structure of high molecular mass urokinase from human urine. The complete amino acid sequence of the A chain.

  1982cited by this paper
• On the role of the carbohydrate side chains of human plasminogen in its interaction with alpha 2-antiplasmin and fibrin.

  1981cited by this paper
• Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.

  1978cited by this paper

• The autoactivation of human single-chain urokinase-type plasminogen activator (uPA)

  2023cites this paper
• Reactive Oxygen Species in Venous Thrombosis

  2020cites this paper
• Matrix metalloproteinase-3 predicts clinical cardiovascular outcomes in patients with coronary artery disease: a 5 years cohort study

  2019cites this paper
• Functional Roles of Matrix Metalloproteinases in Bone Metastatic Prostate Cancer

  2017cites this paper
• Matrix metalloproteinases in bone marrow : roles of gelatinases in physiological hematopoiesis and hematopoietic malignancies

  2017cites this paper
• Mechanisms of the Fibrin Deposits Formation

  2016cites this paper
• Endothelial progenitor cells accelerate the resolution of deep vein thrombosis.

  2016cites this paper
• Fibrinolytic PLGA nanoparticles for slow clot lysis within abdominal aortic aneurysms attenuate proteolytic loss of vascular elastic matrix.

  2016cites this paper
• Usefulness of Plasma Matrix Metalloproteinase-3 Levels to Predict Myocardial Infarction in Men With and Without Acute Coronary Syndrome.

  2016cites this paper
• Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage.

  2015cites this paper
• Structure and function of plasminogen/plasmin system

  2014cites this paper
• Matrix metalloproteinases in coronary artery disease.

  2014cites this paper
• Atlas of Genetics and Cytogenetics in Oncology and Haematology

  2014cites this paper
• [Structure and functions of plasminogen/plasmin system].

  2014cites this paper
• uPA and MMP‐2 were involved in self‐assembled network formation in a two dimensional co‐culture model of bone marrow stromal cells and endothelial cells

  2013cites this paper
• Matrix Metalloproteinase 3/Stromelysin 1

  2013cites this paper
• fibrin-collagen matrix Membrane-type matrix metalloproteinase-mediated angiogenesis in a

  2013cites this paper
• [Aortic stenosis and extracellular matrix remodeling].

  2012cites this paper
• INTERAÇÃO DE LEPTOSPIRA INTERROGANS COM O SISTEMA PROTEOLÍTICO PLASMINOGÊNIO / PLASMINA: ANÁLISE, CARACTERIZAÇÃO E POSSÍVEIS IMPLICAÇÕES NA INFECÇÃO

  2012cites this paper
• Matrix metalloproteinase‐3 in the central nervous system: a look on the bright side

  2012cites this paper
• RLN2 and its role in cancer

  2011cites this paper
• Estudio de la expresión génica de diversos componentes del sistema fibrinolítico de las metaloproteasas y de la angiogénesis en la endometriosis. Correlación de los niveles de expresión con algunos polimorfismos estudiados

  2011cites this paper
• Role of matrix metalloproteinase‐3 in neurodegeneration

  2011cites this paper
• Invited review: Plasmin protease in milk: current knowledge and relevance to dairy industry.

  2010cites this paper
• Developing novel platelet-based targeting strategies for thrombolytics

  2010cites this paper
• Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation.

  2010cites this paper
• Contribution of the fibrinolytic pathway to hematopoietic regeneration

  2009cites this paper
• Regulation of arterial remodeling and angiogenesis by urokinase-type plasminogen activator.

  2009cites this paper
• Effect of cyclic tensile load on the regulation of the expression of matrix metalloproteases (MMPs -1, -3) and structural components in synovial cells

  2008cites this paper
• Urokinase-type plasminogen activator and metalloproteinase-2 are independently related to the carotid atherosclerosis in haemodialysis patients.

  2008cites this paper
• Pharmacoproteomics of a Metalloproteinase Hydroxamate Inhibitor in Breast Cancer Cells: Dynamics of Membrane Type 1 Matrix Metalloproteinase-Mediated Membrane Protein Shedding

  2008cites this paper
• Phospholipase Cgamma1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade.

  2007cites this paper
• Angiopoietin-2 and platelet-derived growth-BB factor cooperatively affect peripheral blood monocyte fibrinolysis

  2007cites this paper
• Low Dose Geldanamycin Inhibits Hepatocyte Growth Factor- and Hypoxia-Stimulated Invasion of Cancer Cells

  2007cites this paper
• Enhanced fibrinolysis in fingerstick blood samples: a possible role for matrix metalloproteinase-9.

  2007cites this paper
• Matrix metalloproteinases in bone marrow: roles of gelatinases in physiological hematopoiesis and hematopoietic malignancies.

  2006cites this paper
• Activity and nature of plasminogen activators associated with the casein micelle.

  2006cites this paper
• Matrix metalloproteinases: roles in cancer and metastasis.

  2006cites this paper
• Matrix Metalloproteinases: Mediators of Tumour-Host Cell Interactions

  2005cites this paper
• Time-dependent changes in myocardial structure following discrete injury in mice deficient of matrix metalloproteinase-3.

  2005cites this paper
• Effects of Pseudomonas fluorescens M3/6 bacterial protease on plasmin system and plasminogen activation.

  2005cites this paper
• Rôle des protéinases et de leurs inhibiteurs dans les formes associées à une néovascularisation anormale sous-rétinienne. Caractérisation par l’étude de modèles animaux transgéniques et développements thérapeutiques.

  2005cites this paper
• Matrix metalloproteinases in multiple myeloma

  2004cites this paper
• Plasminogen Activators in Vascular Remodeling and Angiogenesis

  2004cites this paper
• Matrix Metalloproteinases and Cellular Fibrinolytic Activity

  2004cites this paper
• Proteases at the Endometrial–Trophoblast Interface: Their Role in Implantation

  2004cites this paper
• Current concepts of tumour metastasis.

  2003cites this paper
• Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix.

  2003cites this paper
• Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Structure , Function , and Biochemistry

  2003cites this paper
• Tumor Tissue Concentrations of the Proteinase Inhibitors Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and Plasminogen Activator Inhibitor Type 1 (PAI-1) Are Complementary in Determining Prognosis in Primary Breast Cancer *

  2003cites this paper
• Complex regulation of decidualization: a role for cytokines and proteases--a review.

  2003cites this paper
• Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry

  2003cites this paper
• Relaxin‐like peptides in cancer

  2003cites this paper
• Immunoassays of urokinase (uPA) and its type-1 inhibitor (PAI-1) in detergent extracts of breast cancer tissue.

  2003cites this paper
• Metalloproteinases and plasminogen activators in vessel remodeling

  2003cites this paper
• Plasminogen: Structure, Activation, and Regulation

  2003cites this paper
• Effects of HDL3 on the expression of matrix-degrading proteases in human endothelial cells.

  2003cites this paper
• Thrombolysis on the Horizon: New Thrombolytic Agents and Strategies

  2003cites this paper
• Role of the Plasminogen and MMP Systems in Wound Healing

  2003cites this paper
• Plasminogen Activators: Structure and Function

  2003cites this paper
• Metalloproteases Cleave the Urokinase-Type Plasminogen Activator Receptor in the D1-D2 Linker Region and Expose Epitopes not Present in the intact Soluble Receptor

  2002cites this paper
• Inhibition of human MDA-MB-231 breast cancer cell invasion by matrix metalloproteinase 3 involves degradation of plasminogen.

  2002cites this paper
• Restoration of TGF-beta regulation of plasminogen activator inhibitor-1 in Smad3-restituted human choriocarcinoma cells.

  2002cites this paper
• A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells.

  2001cites this paper
• Matrix metalloproteinase deficiencies do not impair cell-associated fibrinolytic activity.

  2001cites this paper
• Critical role of glutamic acid 202 in the enzymatic activity of stromelysin-1 (MMP-3).

  2001cites this paper
• Urinary-type Plasminogen Activator (uPA)

  2001cites this paper
• Extracellular proteolysis in the development and progression of atherosclerosis.

  2001cites this paper
• Plasmin and Matrix Metalloproteinases in Vascular Remodeling

  2001cites this paper
• Inactivation of the serpin alpha(2)-antiplasmin by stromelysin-1.

  2001cites this paper
• Elements of the Fibrinolytic System

  2001cites this paper
• Cooperation of urokinase plasminogen activator and matrix metalloproteinases in NK cell invasion.

  2000cites this paper
• Molecular interactions between the plasminogen/plasmin and matrix metalloproteinase systems

  2000cites this paper
• Matrix metalloproteinases: multifunctional contributors to tumor progression.

  2000cites this paper
• Matrix metalloproteinases: effectors of development and normal physiology.

  2000cites this paper
• Inactivation of Plasminogen Activator Inhibitor-1 by Specific Proteolysis with Stromelysin-1 (MMP-3)*

  2000cites this paper
• Contribution of the plasmin/matrix metalloproteinase cascade to the retraction of human fibroblast populated collagen lattices.

  2000cites this paper
• Urokinase‐derived peptides regulate vascular smooth muscle contraction in vitro and in vivo

  2000cites this paper
• Prostromelysin-1 (proMMP-3) stimulates plasminogen activation by tissue-type plasminogen activator.

  2000cites this paper
• Determination of the complex between urokinase and its type-1 inhibitor in plasma from healthy donors and breast cancer patients.

  1999cites this paper
• Mechanisms of Signaling through Urokinase Receptor and the Cellular Response

  1999cites this paper
• Matrix Metalloproteinase System Deficiencies and Matrix Degradation

  1999cites this paper
• Pharmacology and clinical trial results of saruplase (scuPA) in acute myocardial infarction.

  1999cites this paper
• Metal loproteases in remodeling of vascular extracellular matrix

  1999cites this paper
• Survey of the 1998 optical biosensor literature

  1999cites this paper
• Modulation of Cell-associated Plasminogen Activation by Stromelysin-1 (MMP-3)

  1999influential citation
• This Review Is Part of a Thematic Series on Matrix Metalloproteinases, Which Includes the following Articles: Matrix Metalloproteinase Inhibition after Myocardial Infarction: a New Approach to Prevent Heart Failure? Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis: the Good, the Ba

  year unknowncites this paper
• Effects of Pseudomonas fluorescens M3/6 Bacterial Protease on Plasmin System and Plasminogen Activation

  year unknowncites this paper