The neurotrophin receptor p75NTR in Schwann cells is implicated in remyelination and motor recovery after peripheral nerve injury

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Glia

• Publication date

  2007-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/glia.20533PMID 17600367
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Knockout of p75NTR impairs re‐myelination of injured sciatic nerve in mice

  2006influential reference
• Neuregulin 1–erbB Signaling Is Necessary for Normal Myelination and Sensory Function

  2006cited by this paper
• Neurite Outgrowth is Directed by Schwann Cell Alignment in the Absence of Other Guidance Cues

  2005cited by this paper
• BDNF overexpression produces a long‐term increase in myelin formation in the peripheral nervous system

  2004cited by this paper
• Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

  2004cited by this paper
• Suppression of p75NTR Does Not Promote Regeneration of Injured Spinal Cord in Mice

  2004influential reference
• Multi‐tasking by the p75 neurotrophin receptor: sortilin things out?

  2004cited by this paper
• Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases.

  2004cited by this paper
• Activation of the transcription factor NF-kappaB in Schwann cells is required for peripheral myelin formation.

  2003cited by this paper
• Activation of the transcription factor NF-κB in Schwann cells is required for peripheral myelin formation

  2003cited by this paper
• The local differentiation of myelinated axons at nodes of Ranvier

  2003influential reference
• Dose-Dependent Effects of FK506 on Neuroregeneration in a Rat Model

  2003cited by this paper
• The Neurotrophin Receptor p75NTR as a Positive Modulator of Myelination

  2002influential reference
• Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport

  2002cited by this paper
• The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho

  2002cited by this paper
• Transplantation of Olfactory Mucosa Minimizes Axonal Branching and Promotes the Recovery of Vibrissae Motor Performance after Facial Nerve Repair in Rats

  2002influential reference
• Neurotrophin signaling through the p75 neurotrophin receptor.

  2002cited by this paper
• Inaugural Article: Neurotrophins are key mediators of the myelination program in the peripheral nervous system

  2001cited by this paper
• Schwann cells and oligodendrocytes read distinct signals in establishing myelin sheath thickness

  2001cited by this paper
• The neurotrophin receptors, trkB and p75, differentially regulate motor axonal regeneration.

  2001cited by this paper
• p75 Is Important for Axon Growth and Schwann Cell Migration during Development

  2000cited by this paper
• Endogenous BDNF is required for myelination and regeneration of injured sciatic nerve in rodents

  2000cited by this paper
• Changes in the compound action current amplitudes in relation to the conduction velocity and functional recovery in the reconstructed peripheral nerve

  1999influential reference
• Functional indices for sciatic, peroneal, and posterior tibial nerve lesions in the mouse

  1998influential reference
• Abnormalities in the axonal cytoskeleton induced by a connexin32 mutation in nerve xenografts

  1998cited by this paper
• Differential Effects of Neurotrophic Factors on Motoneuron Retrograde Labeling in a Murine Model of Motoneuron Disease

  1998cited by this paper
• Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.

  1996cited by this paper
• Selective Activation of NF-κB by Nerve Growth Factor Through the Neurotrophin Receptor p75

  1996cited by this paper
• Nerve growth factor and its low-affinity receptor promote Schwann cell migration.

  1994cited by this paper
• Modulation of axon diameter and neurofilaments by hypomyelinating Schwann cells in transgenic mice

  1994cited by this paper
• Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve

  1993cited by this paper
• Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration.

  1993cited by this paper
• Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system.

  1992cited by this paper
• Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA

  1992cited by this paper
• Three markers of adult non-myelin-forming Schwann cells, 217c(Ran-1), A5E3 and GFAP: development and regulation by neuron-Schwann cell interactions.

  1990cited by this paper
• Rat sciatic functional index data management system with digitized input.

  1984influential reference
• Increased regeneration rate in peripheral nerve axons following double lesions: enhancement of the conditioning lesion phenomenon.

  1983cited by this paper
• How are sheath dimensions affected by axon caliber and internode length?

  1982influential reference
• Determinants of conduction velocity in myelinated nerve fibers

  1980cited by this paper
• Relation between the number of myelin lamellae and axon circumference in fibers of vagus and sciatic nerves of mice

  1967influential reference

• Neurotoxic effects of 3.5 GHz GSM-like RF exposure on cultured DRG neurons: a mechanistic insight into oxidative and apoptotic pathways.

  2026cites this paper
• Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair

  2025cites this paper
• Morphological Characterization of Glial Cells Surrounding Cajal's Initial Glomerulus of the Dorsal Root Ganglion Neurons Revealed Myelinating Schwann Cell Production

  2025cites this paper
• Neurons Are Not All the Same: Diversity in Neuronal Populations and Their Intrinsic Responses to Spinal Cord Injury

  2025cites this paper
• TFEB/3 Govern Repair Schwann Cell Generation and Function Following Peripheral Nerve Injury

  2024cites this paper
• Effects of Sphingosine-1-Phosphate on the Facilitation of Peripheral Nerve Regeneration

  2024cites this paper
• Olfactory Mucosa-Derived Mesenchymal Stem Cells Differentiate Towards a Schwann Cell-Like Phenotype Towards Sourcing for Peripheral Nerve Regeneration

  2024cites this paper
• Autophagy-targeting modulation to promote peripheral nerve regeneration

  2024cites this paper
• Influence of Magnesium Degradation on Schwannoma Cell Responses to Nerve Injury Using an In Vitro Injury Model

  2024cites this paper
• Strain-induced bands of Büngner formation promotes axon growth in 3D tissue-engineered constructs

  2024cites this paper
• Epothilone B loaded in acellular nerve allograft enhanced sciatic nerve regeneration in rats

  2023cites this paper
• Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders

  2023cites this paper
• Schwann cell functions in peripheral nerve development and repair.

  2023cites this paper
• ADAM17 Regulates p75NTR-Mediated Fibrinolysis and Nerve Remyelination

  2022cites this paper
• Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression

  2022cites this paper
• Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit?

  2022cites this paper
• COBRE for Skeletal Health and Repair: The Impact of Aging on the Capacity for Peripheral Nerve Regeneration.

  2021cites this paper
• Impact of NIH's Institutional Development Award (IDeA) Programs in Rhode Island.

  2021cites this paper
• Characterising cellular and molecular features of human peripheral nerve degeneration

  2020cites this paper
• Role of neurotrophic factors in enhancing linear axonal growth of ganglionic sensory neurons in vitro

  2020cites this paper
• Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration

  2020cites this paper
• regional and improvement

  2020cites this paper
• Tissue Engineered Bands of Büngner for Accelerated Motor and Sensory Axonal Outgrowth

  2020cites this paper
• SDF‐1α gene‐activated collagen scaffold drives functional differentiation of human Schwann cells for wound healing applications

  2020cites this paper
• Early regeneration of axons following peripheral nerve injury is enhanced if p75NTR is eliminated from the surrounding pathway

  2020cites this paper
• Axo‐glial interaction in the injured PNS

  2020cites this paper
• Partial deletion of p75NTR in large‐diameter DRG neurons exerts no influence upon the survival of peripheral sensory neurons in vivo

  2020cites this paper
• Hydroxytyrosol Promotes Proliferation of Human Schwann Cells: An In Vitro Study

  2020cites this paper
• Regenerative Capacities of Chitosan-Nanoselenium Conduit on Transected Sciatic Nerve in Diabetic Rats: An Animal Model Study

  2020cites this paper
• Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression

  2019influential citation
• The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1

  2019cites this paper
• The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met

  2019cites this paper
• Glial Plasticity in the Trigeminal Root Entry Zone of a Rat Trigeminal Neuralgia Animal Model

  2019cites this paper
• Transforming Growth Factor Beta 1 Regulates Fibroblast Growth Factor 7 Expression in Schwann Cells

  2019cites this paper
• p75 Neurotrophin Receptor: A Double-Edged Sword in Pathology and Regeneration of the Central Nervous System

  2018cites this paper
• Single Local Application of TGF‐&bgr; Promotes a Proregenerative State Throughout a Chronically Injured Nerve

  2018cites this paper
• Schwann cell lamellipodia regulate cell‐cell interactions and phagocytosis☆

  2018cites this paper
• The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons

  2018influential citation
• Possible utility of contrast-enhanced ultrasonography for detecting spread of local anesthetic in nerve block

  2017cites this paper
• Roles of p75NTR in Maintaining Brain Hemostasis and the Implications for p75NTR-targeted Therapies.

  2017cites this paper
• Evidence for mast cells contributing to neuromuscular pathology in an inherited model of ALS.

  2017cites this paper
• [Research progress of P75 neurotrophin receptor and new idea of nonunion treatment].

  2017cites this paper
• Microambiente celular neurodegenerativo en un modelo de Esclerosis Lateral Amiotrófica

  2017cites this paper
• Dual-Component Gelatinous Peptide/Reactive Oligomer Formulations as Conduit Material and Luminal Filler for Peripheral Nerve Regeneration

  2017cites this paper
• Decreased Axon Caliber Underlies Loss of Fiber Tract Integrity, Disproportional Reductions in White Matter Volume, and Microcephaly in Angelman Syndrome Model Mice

  2017cites this paper
• Effects of Short Term Hypoxia-Preconditioning on Glial Phenotype Induction of Human Mesenchymal Stem Cells

  2017cites this paper
• Nerve Growth Factor and Pain Mechanisms.

  2017cites this paper
• Taking a bite out of spinal cord injury: do dental stem cells have the teeth for it?

  2016cites this paper
• Cognitive deficits are ameliorated by reduction in amyloid β accumulation in Tg2576/p75(NTR+/-) mice.

  2016cites this paper
• Impairment of toll-like receptors 2 and 4 leads to compensatory mechanisms after sciatic nerve axotomy

  2016cites this paper
• Adipose‐derived stem cells protect against endoneurial cell death: Cell therapy for nerve autografts

  2015cites this paper
• Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS)

  2015cites this paper
• Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease.

  2015cites this paper
• Gene expression profiling studies in regenerating nerves in a mouse model for CMT1X: uninjured Cx32-knockout peripheral nerves display expression profile of injured wild type nerves.

  2015cites this paper
• The p75 neurotrophin receptor: at the crossroad of neural repair and death

  2015cites this paper
• Neurotrophins and Neuropathic Pain: Role in Pathobiology

  2015cites this paper
• Neuroprotection in demyelinating diseases: The therapeutic potential of the neurotrophins

  2014cites this paper
• Eccentric contractions of gastrocnemius muscle‐induced nerve damage in rats

  2014cites this paper
• Peripheral Nerve Injury Modulates Neurotrophin Signaling in the Peripheral and Central Nervous System

  2014cites this paper
• Dynamic Nature of the p75 Neurotrophin Receptor in Response to Injury and Disease

  2014cites this paper
• Nerve injury induces glial cell line‐derived neurotrophic factor (gdnf) expression in schwann cells through purinergic signaling and the pkc‐pkd pathway

  2013cites this paper
• Nanofiber scaffolds facilitate functional regeneration of peripheral nerve injury.

  2013cites this paper
• Biology of Schwann cells.

  2013cites this paper
• Characterisation and application of olfactory ensheathing cells for glaucoma induced optic nerve damage

  2012cites this paper
• Insights into the nature and immune escape of a transmissible cancer in Tasmanian devils

  2012cites this paper
• Distribution of P75 neurotrophin receptor in adult human cochlea—an immunohistochemical study

  2012cites this paper
• Evalulating Environmental Cues that Affect Schwann Cell Gene Expression to Enhance Peripheral Nerve Regeneration

  2012cites this paper
• ProBDNF Collapses Neurite Outgrowth of Primary Neurons by Activating RhoA

  2012cites this paper
• Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage

  2012cites this paper
• Proliferating Immature Schwann Cells Contribute to Nerve Regeneration After Ischemic Peripheral Nerve Injury

  2012cites this paper
• p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity.

  2012cites this paper
• Multiple Functions of the P75 Neurotrophin Receptor in the Nervous System

  2012cites this paper
• In vivo assessment of peripheral nerve regeneration by diffusion tensor imaging

  2011cites this paper
• Generation of mice with a conditional allele for the p75NTR neurotrophin receptor gene

  2011cites this paper
• TACE (ADAM17) inhibits Schwann cell myelination

  2011cites this paper
• Transient lysosomal activation is essential for p75 nerve growth factor receptor expression in myelinated Schwann cells during Wallerian degeneration

  2011cites this paper
• Endogenous glucocorticoids improve myelination via Schwann cells after peripheral nerve injury: An in vivo study using a crush injury model

  2010cites this paper
• Retrograde axonal tracing using manganese enhanced magnetic resonance imaging

  2010cites this paper
• Fibrin matrices with affinity‐based delivery systems and neurotrophic factors promote functional nerve regeneration

  2010cites this paper
• Is inhibition of axonal regeneration by astrocytes, in the dorsal part of the spinal cord, regulated by p75 receptor?

  2010cites this paper
• Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats – possible roles of brain‐derived 
neurotrophic factor, TrkB and p75 neurotrophin receptor

  2009cites this paper
• Correlation of three sciatic functional indices with histomorphometric findings in a rat sciatic nerve allograft repair model

  2009cites this paper
• Proteasome inhibition suppresses Schwann cell dedifferentiation in vitro and in vivo

  2009influential citation
• Deletion of p75NTR impairs regeneration of peripheral nerves in mice.

  2009cites this paper
• Altered cutaneous nerve regeneration in a simian immunodeficiency virus / macaque intracutaneous axotomy model

  2009influential citation
• Multiple Roles of the p75 Neurotrophin Receptor in the Nervous System

  2009cites this paper
• The Role of Neurotrophins in the Regulation of Myelin Development

  2009cites this paper
• The function of p75NTR in glia.

  2008cites this paper
• Physiological role of basic FGF in peripheral nerve development and regeneration: potential for reconstruction approaches

  2008cites this paper
• Peripherally-Derived BDNF Promotes Regeneration of Ascending Sensory Neurons after Spinal Cord Injury

  2008cites this paper
• Directing traffic in neural cells: determinants of receptor tyrosine kinase localization and cellular responses

  2008cites this paper
• Hyperglycaemia inhibits Schwann cell proliferation and migration and restricts regeneration of axons and Schwann cells from adult murine DRG.

  2008cites this paper
• Facteurs cellulaires et moléculaires influençant la régénération axonale dans les systèmes nerveux central et périphérique

  2008cites this paper
• p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction.

  2008cites this paper
• A new model of end-to-side nerve graft for multiple branch reconstruction: end-to-side cross-face nerve graft in rats.

  2008cites this paper