The mechanism of myeloperoxidase-dependent chlorination of monochlorodimedon.

No abstract is available for this paper.

• Publication year

  1988

• Venue

  Biochimica et Biophysica Acta

• Publication date

  1988-11-23

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0167-4838(88)90271-3PMID 2847800
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Superoxide modulates the activity of myeloperoxidase and optimizes the production of hypochlorous acid.

  1988cited by this paper
• Candidacidal Activity of Monocyte‐Derived Human Macrophages: Relationship Between Candida Killing and Oxygen Radical Generation by Human Macrophages

  1987cited by this paper
• Kinetics of the oxidation of ascorbic acid, ferrocyanide and p-phenolsulfonic acid by chloroperoxidase compounds I and II.

  1987cited by this paper
• Reaction of human myeloperoxidase with hydrogen peroxide and its true catalase activity.

  1987cited by this paper
• Involvement of leukocytes in the oxygenation and chlorination reaction of phenylbutazone.

  1986cited by this paper
• On the molecular mechanism of lactoperoxidase-catalyzed H2O2 metabolism and irreversible enzyme inactivation.

  1986cited by this paper
• Production of the superoxide adduct of myeloperoxidase (compound III) by stimulated human neutrophils and its reactivity with hydrogen peroxide and chloride.

  1985cited by this paper
• Resonance Raman evidence of chloride binding to the heme iron in myeloperoxidase

  1985cited by this paper
• Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of the oxidant to hypochlorite.

  1985cited by this paper
• A kinetic study of the reaction between human myeloperoxidase, hydroperoxides and cyanide. Inhibition by chloride and thiocyanate.

  1984cited by this paper
• Evidence for a radical mechanism of halogenation of monochlorodimedone catalyzed by chloroperoxidase.

  1984cited by this paper
• Vitamin C stimulates the chlorinating activity of human myeloperoxidase.

  1984cited by this paper
• ENZYMATIC GENERATION OF TRIPLET BIACETYL

  1982cited by this paper
• A kinetic analysis of the interaction of human myeloperoxidase with hydrogen peroxide, chloride ions, and protons.

  1982cited by this paper
• Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

  1982cited by this paper
• Oxidation of methionine by human polymorphonuclear leukocytes.

  1980cited by this paper
• The halide complexes of myeloperoxidase and the mechanism of the halogenation reactions.

  1980cited by this paper
• Enzyme structure and mechanism

  1977cited by this paper
• Chlorination by the Myeloperoxidase-H2O2-CI-Antimicrobial System at Acid and Neutral pH

  1977cited by this paper
• Biosynthesis of thyroid hormone: basic and clinical aspects.

  1977cited by this paper
• Studies on the chlorinating activity of myeloperoxidase.

  1976cited by this paper
• The oxidation of dithiothreitol by peroxidases and oxygen.

  1976cited by this paper
• Free radicals and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase.

  1975cited by this paper
• Chloroperoxidase. 8. Formation of peroxide and halide complexes and their relation to the mechanism of the halogenation reaction.

  1970cited by this paper
• Myeloperoxidase-Halide-Hydrogen Peroxide Antibacterial System

  1968cited by this paper
• Chloroperoxidase. II. Utilization of halogen anions.

  1966cited by this paper
• A comparative study of the end-products of uric acid oxidation by peroxidases.

  1955cited by this paper
• The determination of enzyme inhibitor constants.

  1953cited by this paper
• A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.

  1952cited by this paper
• Baroceptive Impulses in the Carotid Sinus and Their Relation to the Pressure Reflex

  1941cited by this paper

• A patent review of myeloperoxidase inhibitors for treating chronic inflammatory syndromes (focus on cardiovascular diseases, 2013-2019)

  2020cites this paper
• A real-time-based in vitro assessment of the oxidative antimicrobial mechanisms of the myeloperoxidase-hydrogen peroxide-halide system.

  2019cites this paper
• Pharmacophore-based discovery of 2-(phenylamino)aceto-hydrazides as potent eosinophil peroxidase (EPO) inhibitors

  2018cites this paper
• Dansylglycine, a fluorescent probe for specific determination of halogenating activity of myeloperoxidase and eosinophil peroxidase.

  2017cites this paper
• Antioxidant Activity/Capacity Measurement. 3. Reactive Oxygen and Nitrogen Species (ROS/RNS) Scavenging Assays, Oxidative Stress Biomarkers, and Chromatographic/Chemometric Assays.

  2016cites this paper
• Rational drug design approach of the myeloperoxidase inhibition: From in silico to pharmacological activity

  2016cites this paper
• Kinetic method for assaying the halogenating activity of myeloperoxidase based on reaction of celestine blue B with taurine halogenamines

  2015cites this paper
• Novel Cellular Luminescence Probes for Immunological and Toxicological Assessments

  2015cites this paper
• Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity

  2015cites this paper
• Transiently Produced Hypochlorite Is Responsible for the Irreversible Inhibition of Chlorite Dismutase

  2014cites this paper
• Measuring chlorine bleach in biology and medicine.

  2014cites this paper
• Impact of myeloperoxidase-LDL interactions on enzyme activity and subsequent posttranslational oxidative modifications of apoB-100

  2014cites this paper
• Design, synthesis and study of myeloperoxidase inhibitors in the series of 3-alkylindole

  2013cites this paper
• A Stable Bacterial Peroxidase with Novel Halogenating Activity and an Autocatalytically Linked Heme Prosthetic Group*

  2013influential citation
• The free amino acid tyrosine enhances the chlorinating activity of human myeloperoxidase.

  2012cites this paper
• Manipulating the proximal triad His-Asn-Arg in human myeloperoxidase.

  2011cites this paper
• (-)-Epicatechin enhances the chlorinating activity of human myeloperoxidase.

  2010cites this paper
• Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations.

  2010cites this paper
• Essential Role of Proximal Histidine-Asparagine Interaction in Mammalian Peroxidases*

  2009cites this paper
• Role of -463G/A Promoter Polymorphism of Myeloperoxidase in the Development of Atherosclerosis

  2009cites this paper
• Disruption of the Aspartate to Heme Ester Linkage in Human Myeloperoxidase

  2007cites this paper
• The vinyl-sulfonium bond in human myeloperoxidase: impact on compound I formation and reduction by halides and thiocyanate.

  2007cites this paper
• Effects of MCI-186 upon neutrophil-derived active oxygens

  2007cites this paper
• Myeloperoxidase: a target for new drug development?

  2007influential citation
• Reactions of superoxide with myeloperoxidase.

  2007cites this paper
• pH-dependent regulation of myeloperoxidase activity

  2006cites this paper
• Modeling the Reactions of Superoxide and Myeloperoxidase in the Neutrophil Phagosome

  2006cites this paper
• A sensitive and selective assay for chloramine production by myeloperoxidase.

  2005cites this paper
• Role of the covalent glutamic acid 242-heme linkage in the formation and reactivity of redox intermediates of human myeloperoxidase.

  2005cites this paper
• Interaction of hypohalous acids and heme peroxidases with unsaturated phosphatidylcholines

  2005influential citation
• Redox properties of myeloperoxidase

  2003cites this paper
• The Production and Use of Reactive Oxidants by Phagocytes

  2002cites this paper
• Food-Derived Antioxidants: How to Evaluate Their Importance in Food and In Vivo

  2001cites this paper
• Dissociation of DNA double strand by hypohalous acids

  2000cites this paper
• Kinetics of chlorination of monochlorodimedone by myeloperoxidase

  2000influential citation
• Mechanism of Reaction of Myeloperoxidase with Nitrite*

  2000cites this paper
• Comparison of HOCl traps with myeloperoxidase inhibitors in prevention of low density lipoprotein oxidation.

  2000influential citation
• The Sulfonium Ion Linkage in Myeloperoxidase

  1999cites this paper
• NADPH as a co-substrate for studies of the chlorinating activity of myeloperoxidase.

  1999cites this paper
• Characterization of the Asp94 and Glu242 mutants in myeloperoxidase, the residues linking the heme group via ester bonds.

  1999cites this paper
• Secretion and inactivation of myeloperoxidase by isolated neutrophils

  1997cites this paper
• Thiocyanate and chloride as competing substrates for myeloperoxidase.

  1997cites this paper
• Antioxidants: the basics--what they are and how to evaluate them.

  1997cites this paper
• Neutrophils convert tyrosyl residues in albumin to chlorotyrosine

  1996cites this paper
• Oxidative sensitivity of alternative functions of the glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase

  1995cites this paper
• The characterization of antioxidants.

  1995cites this paper
• Antioxidant characterization. Methodology and mechanism.

  1995cites this paper
• How to characterize an antioxidant: an update.

  1995cites this paper
• Chlorination of Tyrosyl Residues in Peptides by Myeloperoxidase and Human Neutrophils (*)

  1995cites this paper
• Assays for the chlorination activity of myeloperoxidase.

  1994cites this paper
• Chlorination of taurine by myeloperoxidase. Kinetic evidence for an enzyme-bound intermediate.

  1994cites this paper
• Oxidant-scavenging activities of ampicillin and sulbactam and their effects on neutrophil functions

  1993cites this paper
• N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system.

  1993cites this paper
• Myeloperoxidase-dependent loss of malondialdehyde: a limitation for detecting neutrophil-mediated lipid peroxidation.

  1993cites this paper
• Oxidation of desferrioxamine to nitroxide free radical by activated human neutrophils.

  1993cites this paper
• Interaction of acetaminophen with myeloperoxidase intermediates: optimum stimulation of enzyme activity.

  1993cites this paper
• Myeloperoxidase-mediated activation of xenobiotics by human leukocytes.

  1993cites this paper
• Effect of NPC 15669, an inhibitor of neutrophil recruitment and neutrophil-mediated inflammation, on neutrophil function in vitro.

  1993cites this paper
• Interaction of methyl-xanthines with myeloperoxidase. An anti-inflammatory mechanism.

  1992cites this paper
• Haloperoxidases: Their Properties and Their Use in Organic Synthesis

  1992cites this paper
• Human hemi-myeloperoxidase. Initial chlorinating activity at neutral pH, compound II and III formation, and stability towards hypochlorous acid and high temperature.

  1992cites this paper
• Metabolism of isoniazid by activated leukocytes. Possible role in drug-induced lupus.

  1992cites this paper
• Myeloperoxidase-catalyzed iodination and coupling.

  1992cites this paper
• Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs.

  1991cites this paper
• The influence of superoxide on the production of hypochlorous acid by human neutrophils.

  1991cites this paper
• Mechanisms by which clofazimine and dapsone inhibit the myeloperoxidase system. A possible correlation with their anti-inflammatory properties.

  1991cites this paper
• How to characterize a biological antioxidant.

  1990cites this paper
• The mechanism of myeloperoxidase-catalysed oxidation of aminopyrine.

  1990cites this paper
• The chlorinating activity of human myeloperoxidase: high initial activity at neutral pH value and activation by electron donors.

  1990cites this paper
• Superoxide enhances hypochlorous acid production by stimulated human neutrophils.

  1990cites this paper
• Influence of superoxide on myeloperoxidase kinetics measured with a hydrogen peroxide electrode.

  1989cites this paper