A new paradigm in toxicology and teratology: altering gene activity in the absence of DNA sequence variation.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Reproductive Toxicology

• Publication date

  2007-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.REPROTOX.2007.05.002PMID 17596910
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Loss of imprinting and cancer

  2007cited by this paper
• Dynamic regulation of histone lysine methylation by demethylases.

  2007cited by this paper
• Chromatin modifications and their function.

  2007cited by this paper
• Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells

  2007cited by this paper
• The evolution of gene regulation by transcription factors and microRNAs

  2007cited by this paper
• RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.

  2007cited by this paper
• Illuminating the silence: understanding the structure and function of small RNAs

  2007cited by this paper
• Secondary siRNAs Result from Unprimed RNA Synthesis and Form a Distinct Class

  2007cited by this paper
• Developmental exposure to endocrine disruptors and the obesity epidemic.

  2007cited by this paper
• Distinct Populations of Primary and Secondary Effectors During RNAi in C. elegans

  2007cited by this paper
• Epigenetics in development

  2007influential reference
• Higher-order structures of chromatin: the elusive 30 nm fiber.

  2007cited by this paper
• Developmental estrogen exposures predispose to prostate carcinogenesis with aging.

  2007cited by this paper
• Epigenetic gene regulation: linking early developmental environment to adult disease.

  2007cited by this paper
• Epigenetics: A Landscape Takes Shape

  2007cited by this paper
• Development of new RNAi therapeutics.

  2007cited by this paper
• Gene Body-Specific Methylation on the Active X Chromosome

  2007cited by this paper
• Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum.

  2007influential reference
• The epigenomics of cancer.

  2007cited by this paper
• Strategies for silencing human disease using RNA interference

  2007cited by this paper
• Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases.

  2007cited by this paper
• Amplified Silencing

  2007cited by this paper
• Long term low-dose arsenic exposure induces loss of DNA methylation.

  2007cited by this paper
• Environmental and nutritional effects on the epigenetic regulation of genes.

  2006cited by this paper
• Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band

  2006cited by this paper
• Toward a human epigenome

  2006cited by this paper
• The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

  2006cited by this paper
• Transgenerational epigenetic imprinting of the male germline by endocrine disruptor exposure during gonadal sex determination.

  2006cited by this paper
• The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36

  2006cited by this paper
• Histone demethylation by a family of JmjC domain-containing proteins

  2006cited by this paper
• Epigenetic regulation of chromatin structure and gene function by biotin.

  2006cited by this paper
• Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells

  2006influential reference
• Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease.

  2006cited by this paper
• DNA methylation profiling of human chromosomes 6, 20 and 22

  2006cited by this paper
• Control of translation and mRNA degradation by miRNAs and siRNAs.

  2006cited by this paper
• Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations.

  2006cited by this paper
• RNAdb 2.0—an expanded database of mammalian non-coding RNAs

  2006cited by this paper
• Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions

  2006cited by this paper
• Molecular biology. A new RNA dimension to genome control.

  2006cited by this paper
• Evidence for an instructive mechanism of de novo methylation in cancer cells

  2006cited by this paper
• Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.

  2006cited by this paper
• Modification of proteins by ubiquitin and ubiquitin-like proteins.

  2006cited by this paper
• Epigenetic transgenerational actions of endocrine disruptors.

  2006cited by this paper
• Characterization of the piRNA Complex from Rat Testes

  2006cited by this paper
• Epigenetic therapy of cancer: past, present and future

  2006cited by this paper
• Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications.

  2006cited by this paper
• The epigenetic progenitor origin of human cancer

  2006influential reference
• Transgenerational effect of the endocrine disruptor vinclozolin on male spermatogenesis.

  2006cited by this paper
• Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus.

  2006cited by this paper
• For a healthy histone code, a little SUMO in the tail keeps the acetyl away.

  2006cited by this paper
• Maternal methyl supplements increase offspring DNA methylation at Axin fused

  2006cited by this paper
• A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline

  2006cited by this paper
• A New RNA Dimension to Genome Control

  2006cited by this paper
• Overview of cancer epigenetics.

  2005cited by this paper
• The key to development: interpreting the histone code?

  2005cited by this paper
• Biological functions of biotinylated histones.

  2005cited by this paper
• Association of valproate‐induced teratogenesis with histone deacetylase inhibition in vivo

  2005cited by this paper
• Reversing histone methylation

  2005cited by this paper
• Aberrant DNA methylation as a cancer-inducing mechanism.

  2005cited by this paper
• DNA methylation and human disease

  2005cited by this paper
• Co-evolution of X-chromosome inactivation and imprinting in mammals

  2005cited by this paper
• Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

  2005cited by this paper
• Embryonic and fetal programming of physiological disorders in adulthood.

  2004cited by this paper
• DNA methylation analysis techniques

  2004cited by this paper
• Exposure of Mouse Preimplantation Embryos to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters the Methylation Status of Imprinted Genes H19 and Igf21

  2004cited by this paper
• Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.

  2004cited by this paper
• Role of histone H2A ubiquitination in Polycomb silencing

  2004cited by this paper
• Epigenomics: beyond CpG islands

  2004cited by this paper
• ‘Fetal programming’ and ‘functional teratogenesis’: on epigenetic mechanisms and prevention of perinatally acquired lasting health risks

  2004cited by this paper
• Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo.

  2004cited by this paper
• MicroRNAs: small RNAs with a big role in gene regulation

  2004cited by this paper
• Epigenetics in human disease and prospects for epigenetic therapy

  2004cited by this paper
• Cellular machineries for chromosomal DNA repair.

  2004cited by this paper
• Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation.

  2004cited by this paper
• Histones and histone modifications.

  2004cited by this paper
• Protein modification by SUMO.

  2004cited by this paper
• Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.

  2003cited by this paper
• Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.

  2003cited by this paper
• Early detection: The power and the promise of DNA methylation markers

  2003cited by this paper
• Histone and chromatin cross-talk.

  2003cited by this paper
• Histone sumoylation is associated with transcriptional repression

  2003cited by this paper
• Transcriptional regulation by histone ubiquitination and deubiquitination.

  2003cited by this paper
• From epigenesis to epigenetics: the case of C. H. Waddington.

  2002cited by this paper
• A tale of histone modifications

  2001cited by this paper
• Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.

  2001cited by this paper
• The language of covalent histone modifications

  2000cited by this paper
• Chromatin Modifications and Their Function

  year unknowncited by this paper

• Epigenetic and experimental approaches influencing non-coding RNAs.

  2025cites this paper
• Study of DNA methylation of hsd17β, er and reproductive endocrine disrupting effects in female Chlamys farreri under benzo[a]pyrene stress.

  2023cites this paper
• Study on epigenotoxicity, sex hormone synthesis, and DNA damage of benzo[a]pyrene in the testis of male Ruditapes philippinarum.

  2023cites this paper
• Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice.

  2021cites this paper
• DNA Modifications: Methods and Protocols

  2021cites this paper
• Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis.

  2021cites this paper
• Transgenerational Effects of Di(2-Ethylhexyl) Phthalate on Anogenital Distance, Sperm Functions and DNA Methylation in Rat Offspring

  2021cites this paper
• Protein lysine acetylation and its role in different human pathologies: a proteomic approach

  2021cites this paper
• Epigenetic Modifications, and Alterations in Cell Cycle and Apoptosis Pathway in A549 Lung Carcinoma Cell Line upon Exposure to Perfluoroalkyl Substances

  2020cites this paper
• Bisphenol A-associated alterations in DNA and histone methylation affects semen quality in rare minnow Gobiocypris rarus.

  2020cites this paper
• Genome-Wide Mapping of DNA Methylation 5mC by Methylated DNA Immunoprecipitation (MeDIP)-Sequencing.

  2020cites this paper
• Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects

  2019cites this paper
• Integrated analysis of DNA methylome and transcriptome identified CREB5 as a novel risk gene contributing to recurrent pregnancy loss

  2018cites this paper
• Methylation Status of the Follistatin Gene at Different Development Stages of Japanese Flounder (Paralichthys olivaceus)

  2018cites this paper
• New Technologies for Monitoring Marine Mammal Health

  2018cites this paper
• Reproductive effects linked to DNA methylation in male zebrafish chronically exposed to environmentally relevant concentrations of di-(2-ethylhexyl) phthalate.

  2017cites this paper
• Mechanisms of fetal epigenetics that determine telomere dynamics and health span in adulthood.

  2017cites this paper
• Developmental Origins of Cancer

  2017cites this paper
• Adverse Intrauterine Environment and Cardiac miRNA Expression

  2017cites this paper
• Interacción entre factores genéticosambientales y la epigénesis de la enfermedad de Parkinson

  2016cites this paper
• The relationship between methylation and genes associated with opioid response in humans

  2016cites this paper
• Genetic and Epigenetic Mechanisms Linking Air Pollution and Congenital Heart Disease

  2016cites this paper
• Protocol for Methylated DNA Immunoprecipitation (MeDIP) Analysis

  2016cites this paper
• Deficient expression of aldehyde dehydrogenase 1A1 is consistent with increased sensitivity of Gorlin syndrome patients to radiation carcinogenesis

  2015cites this paper
• Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells

  2015cites this paper
• Modulation of Epigenetic regulation as a novel mechanism in antiinflammatory and anticancer drugs

  2014cites this paper
• DNA methylation in the 5' flanking region of cytochrome P450 17 in adult rare minnow Gobiocypris rarus - tissue difference and effects of 17α-ethinylestradiol and 17α-methyltestoterone exposures.

  2014cites this paper
• Role of BDNF epigenetics in activity-dependent neuronal plasticity.

  2014cites this paper
• Environmental chemical stressors as epigenome modifiers: a new horizon in assessment of toxicological effects

  2014cites this paper
• Global and cyp19a1a gene specific DNA methylation in gonads of adult rare minnow Gobiocypris rarus under bisphenol A exposure.

  2014cites this paper
• Epigenetic DNA changes and stem cells therapy

  2013cites this paper
• Gestational Hypoxia Induces Sex-Differential Methylation of Crhr1 Linked to Anxiety-like Behavior

  2013cites this paper
• Methylation profiling of paternally imprinted loci in male gametes following alcohol exposure

  2012cites this paper
• Algorithms and applications of next-generation DNA sequencing : ChIP-Seq, database of human variations, and analysis of mammary ductal carcinomas

  2012cites this paper
• Insufficient maintenance DNA methylation is associated with abnormal embryonic development

  2012cites this paper
• Asthma Epigenetics: Emergence of a New Paradigm?

  2012cites this paper
• Epigenetics of Environmental Contaminants

  2012cites this paper
• Genetics of amyotrophic lateral sclerosis

  2012cites this paper
• Epigenetics – relevance to drug safety science

  2012cites this paper
• Ambient air pollution exposure and damage to male gametes: human studies and in situ ‘sentinel’ animal experiments

  2011cites this paper
• Epigenetics and environmental exposures

  2011influential citation
• Prenatal environmental exposures, epigenetics, and disease.

  2011influential citation
• renatal environmental exposures , epigenetics , and disease

  2011cites this paper
• Genotoxicities and infertility

  2011cites this paper
• What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?

  2010cites this paper
• Non‐coding RNAs and their epigenetic regulatory mechanisms

  2010cites this paper
• Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds

  2010cites this paper
• DNA methylation levels in the 5' flanking region of the vitellogenin I gene in liver and brain of adult zebrafish (Danio rerio)--sex and tissue differences and effects of 17alpha-ethinylestradiol exposure.

  2010cites this paper
• Smoking and congenital heart disease: the epidemiological and biological link.

  2010cites this paper
• Epigenetics and the Developmental Origins of Health and Disease

  2010cites this paper
• The Impact of Genetic and Environmental Factors in Neurodegeneration: Emerging Role of Epigenetics

  2010cites this paper
• Evaluation of a Male Reproductive Toxicant

  2010cites this paper
• Environmental epigenetics and allergic diseases: recent advances

  2010cites this paper
• Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases.

  2009cites this paper
• Testicular toxicity and the potential for 1, 2 -ethlyene dichloride (EDC) to initiate epigenetic disruption of the paternal genome

  2009cites this paper
• Neonatal exposure to diethylstilbestrol alters expression of DNA methyltransferases and methylation of genomic DNA in the mouse uterus.

  2009cites this paper
• Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation.

  2009cites this paper
• The ghost in our genes: legal and ethical implications of epigenetics.

  2009cites this paper
• Folic acid and methionine in the prevention of teratogen-induced congenital defects in mice.

  2009cites this paper
• Air pollution and mutations in the germline: are humans at risk?

  2009cites this paper
• Mapping the epigenome--impact for toxicology.

  2009cites this paper
• Epigenetic regulation of gap junctional intercellular communication: more than a way to keep cells quiet?

  2009cites this paper
• Genetic Analysis of Bahamian Campsomeris (Hymenoptera: Scoliidae)

  2009cites this paper
• Environmental-induced oxidative stress in neurodegenerative disorders and aging.

  2009cites this paper
• Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation.

  2008cites this paper
• Focus on the Fundamentals: Toward Better Therapeutic Index Prediction

  2008cites this paper
• The next innovation cycle in toxicogenomics: environmental epigenetics.

  2008cites this paper
• A sideways glance. Do you remember your grandmother’s food? How epigenetic changes transmit consequences of nutritional exposure from one generation to the next

  2008cites this paper
• Next Generation Genome Sequencing

  2008cites this paper
• miRNAs: effectors of environmental influences on gene expression and disease.

  2008cites this paper
• Epigenetics and environmental exposures

  year unknowninfluential citation
• Epigenetics and environmental exposures

  year unknowninfluential citation
• Epigenetics and environmental exposures

  year unknowninfluential citation
• Epigenetics and environmental exposures

  year unknowninfluential citation
• Epigenetics and environmental exposures

  year unknowninfluential citation