Selective inhibition of one of the cyclic AMP phosphodiesterases from rat brain by the neurotropic compound rolipram.

No abstract is available for this paper.

• Publication year

  1985

• Venue

  Biochemical Pharmacology

• Publication date

  1985-08-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0006-2952(85)90029-2PMID 2992527
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characteristic behavioral alterations in rats induced by rolipram and other selective adenosine cyclic 3′,5′-monophosphate phosphodiesterase inhibitors

  2004cited by this paper
• Brain cAMP response to phosphodiesterase inhibitors in rats killed by microwave irradiation or decapitation.

  1984cited by this paper
• Assessment of selective inhibition of rat cerebral cortical calcium-independent and calcium-dependent phosphodiesterases in crude extracts using deoxycyclic AMP and potassium ions.

  1984cited by this paper
• Neurotropic effects of the optical isomers of the selective adenosine cyclic 3′,5′‐monophosphate phosphodiesterase inhibitor rolipram in rats in‐vivo

  1983cited by this paper
• Tissue and substrate specificity of inhibition by alkoxy-aryl-lactams of platelet and arterial smooth muscle cyclic nucleotide phosphodiesterases relationship to pharmacological activity.

  1983cited by this paper
• Antidepressant properties of some phosphodiesterase inhibitors.

  1983cited by this paper
• Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors.

  1983cited by this paper
• Selective inhibition of separated forms of cyclic nucleotide phosphodiesterase from rat heart by some cardio- or vaso-active butenolide derivatives.

  1982cited by this paper
• Isoelectric-focusing patterns of cyclic nucleotide phosphodiesterase from rat heart.

  1981cited by this paper
• Cyclic nucleotide phosphodiesterase from a particulate fraction of rat heart. Solubilization and characterization of a single enzymatic form.

  1981cited by this paper
• REGULATION OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES OF CEREBRAL CORTEX BY Ca2+ AND CYCLIC GMP

  1978cited by this paper
• Effects of antiallergic agents, compound 48/80, and some reference inhibitors on the activity of partially purified human lung tissue adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate phosphodiesterases.

  1977cited by this paper
• Stimulation of cyclic nucleotide phosphodiesterases from rat brain by activator protein, proteolytic enzymes and a vitamin E derivative.

  1977cited by this paper
• CYCLIC NUCLEOTIDE PHOSPHODIESTERASE IN RAT NEOSTRIATUM: MULTIPLE ISOELECTRIC FORMS WITH SIMILAR KINETIC PROPERTIES

  1976cited by this paper
• 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711): a potent inhibitor of adenosine cyclic 3',5'-monophosphate phosphodiesterases in homogenates and tissue slices from rat brain.

  1976cited by this paper
• Isolation of an activator of multiple forms of cyclic nucleotides phosphodiesterase of rat cerebrum by isoelectric focusing.

  1975cited by this paper
• Multiple cyclic nucleotide phosphodiesterase activities from rat brain.

  1971cited by this paper
• Further studies of the lipid composition and biochemical properties of Tetrahymena pyriformis membrane systems.

  1971cited by this paper
• Cyclic 3',5'-nucleotide phosphodiesterase, IV. Two enzymes with different properties from brain.

  1971cited by this paper
• Membrane formation in Tetrahymena pyriformis. 4. Lipid composition and biochemical properties of Tetrahymena pyriformis membrane systems

  1971cited by this paper

• Memory suppressor genes: Modulating acquisition, consolidation, and forgetting.

  2021cites this paper
• The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action.

  2017cites this paper
• Synthesis and preclinical evaluation of an 18F labeled PDE7 inhibitor for PET neuroimaging.

  2015cites this paper
• Ion Channel Regulation in Growth Cone Guidance by Semaphorin 3A in Xenopus laevis Spinal Neurons

  2009cites this paper
• Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant.

  2007cites this paper
• Modulation of the cAMP signaling pathway after traumatic brain injury.

  2007cites this paper
• Effects of the phosphodiesterase inhibitor rolipram on the acoustic startle response in rats

  2006cites this paper
• Approaches to palliative therapies for Alzheimer's disease.

  2006cites this paper
• Behaviour of [11C]R(−)‐ and [11C]S(+)‐rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4

  2005cites this paper
• Phosphodiesterase inhibitors for cognitive enhancement.

  2005cites this paper
• Investigation of acute modulation of cAMP in vivo with PET using [11C]rolipram

  2005cites this paper
• Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4).

  2004cites this paper
• Effects of forskolin and cyclic nucleotides in animal models predictive of antidepressant activity: interactions with rolipram

  2004cites this paper
• In Vivo Assessment of Local Phosphodiesterase Activity Using Tailored Cyclic Nucleotide–Gated Channels as Camp Sensors

  2001influential citation
• The influence of phosphodiesterase inhibitor, rolipram, on hemodynamics in lipopolysaccharide-treated rats.

  2001cites this paper
• Purinergic modulation of [(3)H]GABA release from rat hippocampal nerve terminals.

  2000cites this paper
• Phosphodiesterase 4 inhibitors, structurally unrelated to rolipram, as promising agents for the treatment of asthma and other pathologies.

  2000cites this paper
• Substituted furans as inhibitors of the PDE4 enzyme.

  1999cites this paper
• The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions.

  1998cites this paper
• Rolipram, an antidepressant that increases the availability of cAMP, transiently enhances wakefulness in rats.

  1998cites this paper
• Combined effects of insulin and dexamethasone on cyclic AMP phosphodiesterase 3 and glycogen metabolism in cultured rat hepatocytes.

  1998cites this paper
• Chemotherapeutic potential of phosphodiesterase inhibitors.

  1998cites this paper
• Cyclic GMP accumulation in pulmonary microvascular endothelial cells measured by intact cell prelabeling.

  1997cites this paper
• PDE 4 inhibitors: the use of molecular cloning in the design and development of novel drugs

  1997cites this paper
• Identification, Characterization, and Functional Role of Phosphodiesterase Type IV in Cerebral Vessels: Effects of Selective Phosphodiesterase Inhibitors

  1997cites this paper
• Delayed sympathectomy after a prolonged hyperalgesia results in a subsequent enhanced acute hyperalgesic response.

  1996cites this paper
• The Nitric Oxide ‐ Cyclic GMP Pathway and Synaptic Depression in Rat Hippocampal Slices

  1994cites this paper
• Identification of two splice variant forms of type-IVB cyclic AMP phosphodiesterase, DPD (rPDE-IVB1) and PDE-4 (rPDE-IVB2) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions.

  1994cites this paper
• Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma.

  1994cites this paper
• ucb 11056, a New Potential Nootropic Drug, Amplifies Induced Cyclic AMP Formation in Rat Brain Tissue

  1993cites this paper
• Central and peripheral minocycline suppresses motor activity in rats.

  1993cites this paper
• CHAPTER 12 – CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: PHARMACOLOGY, BIOCHEMISTRY AND FUNCTION

  1993cites this paper
• Mediation of serotonin hyperalgesia by the cAMP second messenger system.

  1992cites this paper
• Multiple actions of glaucine on cyclic nucleotide phosphodiesterases, α1‐adrenoceptor and benzothiazepine binding site at the calcium channel

  1992cites this paper
• Pharmacology of second messengers: a critical appraisal.

  1992cites this paper
• Identification of a B2-bradykinin receptor linked to phospholipase C and inhibition of dopamine stimulated cyclic AMP accumulation in the human astrocytoma cell line D384

  1992cites this paper
• Nicotinamide ethers: novel inhibitors of calcium-independent phosphodiesterase and [3H]rolipram binding.

  1991cites this paper
• Forskolin and phosphodiesterase inhibitors release adenosine but inhibit morphine-evoked release of adenosine from spinal cord synaptosomes.

  1991cites this paper
• Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones.

  1991cites this paper
• Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells.

  1991cites this paper
• Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.

  1991cites this paper
• Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function.

  1991cites this paper
• Behavioral effects of rolipram and structurally related compounds in mice: behavioral sedation of cAMP phosphodiesterase inhibitors.

  1991cites this paper
• Effects of lithium and rolipram enantiomers on locomotor activity in inbred mice.

  1990cites this paper
• Direct cutaneous hyperalgesia induced by adenosine.

  1990cites this paper
• The pharmacodynamic action of the cyclic AMP phosphodiesterase inhibitor rolipram on prolactin producing rat pituitary adenoma (GH4C1) cells

  1990cites this paper
• Effects of novel catechol ether imidazolidinones on calcium‐independent phosphodiesterase activity, [3H]rolipram binding, and reserpine‐induced hypothermia in mice

  1990cites this paper
• Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene.

  1989cites this paper
• Isolation of similar rolipram-inhibitable cyclic-AMP-specific phosphodiesterases from rat brain and heart.

  1989cites this paper
• Inhibition of the different cyclic nucleotide phosphodiesterase isoforms separated from rat brain by flavonoid compounds.

  1989cites this paper
• Effect of Isozyme‐Selective Inhibitors of Phosphodiesterase on Histamine‐Stimulated Cyclic AMP Accumulation in Guinea‐Pig Hippocampus

  1989cites this paper
• Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues.

  1989cites this paper
• Absence of Anticholinergic Activity of Rolipram, an Antidepressant with a Novel Mechanism of Action, in three Different Animal Models in Vivo

  1988cites this paper
• Comparison of cyclic nucleotide phosphodiesterase isoforms from rat heart and bovine aorta. Separation and inhibition by selective reference phosphodiesterase inhibitors.

  1988cites this paper
• Brain low-Km cAMP phosphodiesterase.

  1988cites this paper
• Influence of rolipram on the cyclic 3',5'-adenosine monophosphate response to histamine and adenosine in slices of guinea-pig cerebral cortex.

  1988cites this paper
• [71] Brain low-Km cAMP phosphodiesterase

  1988cites this paper
• Tissue specificity of cAMP‐phosphodiesterase inhibitors: Rolipram, amrinone, milrinone, enoximone, piroximone, and imazodan

  1988influential citation
• Defective Second-messenger Function in the Etiology of Endogenous Depression: Novel Therapeutic Approaches

  1988cites this paper
• Effects of an Extract of Ginkgo biloba on the 3′,5′‐Cyclic AMP Phosphodiesterase Activity of the Brain of Normal and Triethyltin‐Intoxicated Rats

  1987cites this paper
• Characterization of soluble cyclic AMP phosphodiesterases and partial purification of a major form in human leiomyoma of the uterus.

  1987cites this paper
• Purification of cAMP-specific phosphodiesterase from rat heart by affinity chromatography on immobilized rolipram.

  1986cites this paper
• Rolipram, a novel antidepressant drug, reverses the hypothermia and hypokinesia of monoamine-depleted mice by an action beyond postsynaptic monoamine receptors.

  1986cites this paper
• The role of spinal cord cyclic AMP in the acoustic startle response in rats

  1986cites this paper
• Stereospecific binding of the antidepressant rolipram to brain protein structures.

  1986cites this paper