Tripeptide GGH as the Inhibitor of Copper-Amyloid-β-Mediated Redox Reaction and Toxicity.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  ACS Chemical Neuroscience

• Publication date

  2016-08-03

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acschemneuro.6b00145PMID 27433833
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Study of a Bifunctional Aβ Aggregation Inhibitor with the Abilities of Antiamyloid-β and Copper Chelation.

  2016cited by this paper
• Regulation of copper and iron homeostasis by metal chelators: a possible chemotherapy for Alzheimer's disease.

  2015cited by this paper
• Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives

  2015cited by this paper
• A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms.

  2015cited by this paper
• A retrievable, water-soluble and biocompatible fluorescent probe for recognition of Cu(II) and sulfide based on a peptide receptor.

  2015cited by this paper
• Design of LVFFARK and LVFFARK-functionalized nanoparticles for inhibiting amyloid β-protein fibrillation and cytotoxicity.

  2015cited by this paper
• Design, synthesis, and evaluation of multitarget-directed selenium-containing clioquinol derivatives for the treatment of Alzheimer's disease.

  2014cited by this paper
• A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's disease.

  2014cited by this paper
• Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.

  2014cited by this paper
• β-Amyloid Fibrils in Alzheimer Disease Are Not Inert When Bound to Copper Ions but Can Degrade Hydrogen Peroxide and Generate Reactive Oxygen Species*

  2014cited by this paper
• Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease.

  2014cited by this paper
• Antioxidant role of amyloid β protein in cell-free and biological systems: implication for the pathogenesis of Alzheimer disease.

  2013cited by this paper
• Role of metal ions in the self-assembly of the Alzheimer's amyloid-β peptide.

  2013cited by this paper
• Bioinorganic chemistry of Alzheimer's disease.

  2012cited by this paper
• Copper and oxidative stress in the pathogenesis of Alzheimer's disease.

  2012cited by this paper
• Clioquinol: Review of its Mechanisms of Action and Clinical Uses in Neurodegenerative Disorders

  2012cited by this paper
• The role of metallobiology and amyloid‐β peptides in Alzheimer’s disease

  2012cited by this paper
• Inhibition of Cu-amyloid-β by using bifunctional peptides with β-sheet breaker and chelator moieties.

  2012cited by this paper
• Cu(II) Mediates Kinetically Distinct, Non-amyloidogenic Aggregation of Amyloid-β Peptides*

  2011cited by this paper
• Copper inducing Aβ42 rather than Aβ40 nanoscale oligomer formation is the key process for Aβ neurotoxicity.

  2011cited by this paper
• Cerebrospinal fluid/plasma quotients of essential and non-essential metals in patients with Alzheimer’s disease

  2011cited by this paper
• Thermodynamic study of Cu2+ binding to the DAHK and GHK peptides by isothermal titration calorimetry (ITC) with the weaker competitor glycine

  2011cited by this paper
• Substoichiometric Levels of Cu2+ Ions Accelerate the Kinetics of Fiber Formation and Promote Cell Toxicity of Amyloid-β from Alzheimer Disease*

  2010cited by this paper
• Copper-induced cytotoxicity: reactive oxygen species or islet amyloid polypeptide oligomer formation.

  2010cited by this paper
• Copper handling machinery of the brain.

  2010cited by this paper
• Ascorbic Acid and Rates of Cognitive Decline in Alzheimer's Disease

  2009cited by this paper
• Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems.

  2009cited by this paper
• Alzheimer's disease, metal ions and metal homeostatic therapy.

  2009cited by this paper
• Electrochemical analysis of copper ion using a Gly-Gly-His tripeptide modified poly(3-thiopheneacetic acid) biosensor.

  2009cited by this paper
• Amyloid beta-Cu2+ complexes in both monomeric and fibrillar forms do not generate H2O2 catalytically but quench hydroxyl radicals.

  2008cited by this paper
• Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.

  2008cited by this paper
• Quantification of the binding constant of copper(II) to the amyloid-beta peptide.

  2008cited by this paper
• Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial.

  2008cited by this paper
• The redox chemistry of the Alzheimer's disease amyloid beta peptide.

  2007cited by this paper
• Human serum albumin coordinates Cu(II) at its N-terminal binding site with 1 pM affinity

  2007cited by this paper
• Redox Chemistry of Copper–Amyloid‐β: The Generation of Hydroxyl Radical in the Presence of Ascorbate is Linked to Redox‐Potentials and Aggregation State

  2007cited by this paper
• Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron.

  2007cited by this paper
• Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease.

  2006cited by this paper
• Pathways towards and away from Alzheimer's disease

  2004cited by this paper
• Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease.

  2002cited by this paper
• Sub-ppt detection limits for copper ions with Gly-Gly-His modified electrodes.

  2001cited by this paper
• New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity.

  2001cited by this paper
• Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

  2001cited by this paper
• Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity.

  2000cited by this paper
• Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase.

  1999cited by this paper
• Copper, iron and zinc in Alzheimer's disease senile plaques.

  1998cited by this paper
• Oxidative stress hypothesis in Alzheimer's disease.

  1997cited by this paper
• A quantitative test for copper using bicinchoninic acid.

  1995cited by this paper
• Subacute myelo-optic neuropathy and clioquinol. An epidemiological case-history for diagnosis.

  1975cited by this paper

• A Cocktail of Two Chelators Is Not Better than One Ligand in Excess to Halt Cu,Zn-(Amyloid-β)-Induced ROS Production in the Context of Alzheimer's Disease.

  2025cites this paper
• Enrichment and functional characterization of copper-binding peptides from food hydrolysates

  2025influential citation
• A smart adaptable metal sequestering peptide conjugate to modulate Aβ fibrillar aggregation.

  2024cites this paper
• Fluorescent Peptides Sequester Redox Copper to Mitigate Oxidative Stress, Amyloid Toxicity, and Neuroinflammation.

  2024cites this paper
• Harnessing the Therapeutic Potential of Peptides for Synergistic Treatment of Alzheimer's Disease by Targeting Aβ Aggregation, Metal-Mediated Aβ Aggregation, Cholinesterase, Tau Degradation, and Oxidative Stress.

  2024cites this paper
• Peptide-based amyloid-beta aggregation inhibitors.

  2024cites this paper
• Rationally Designed Cu(I) Ligand to Prevent CuAβ-Generated ROS Production in the Alzheimer's Disease Context.

  2024cites this paper
• Self-assembling NBD-tripeptide as a dual-mode colorimetric platform for naked eye and smartphone joint detection of micro to nanomolar Copper(II) ions.

  2023cites this paper
• A Molecular Integrative Study on the Inhibitory Effects of WRR and ERW on Amyloid β Peptide (1–42) Polymerization and Cell Toxicity

  2023cites this paper
• Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(Aβ) species: a structure–activity relationship

  2023cites this paper
• Copper(II) Affects the Biochemical Behavior of Proinsulin C-peptide by Forming Ternary Complexes with Serum Albumin.

  2023cites this paper
• Derivatization of the Peptidic Xxx-Zzz-His Motif toward a Ligand with Attomolar CuII Affinity under Maintaining High Selectivity and Fast Redox Silencing.

  2023cites this paper
• Recent Development in the Understanding of Molecular and Cellular Mechanisms Underlying the Etiopathogenesis of Alzheimer’s Disease

  2023cites this paper
• Structure-activity assessment of flavonoids as modulators of copper transport

  2022influential citation
• Sequence–Activity Relationship of ATCUN Peptides in the Context of Alzheimer’s Disease

  2022cites this paper
• Potential of food-derived bioactive peptides in alleviation and prevention of Alzheimer's disease.

  2022cites this paper
• From Small Peptides to Large Proteins against Alzheimer’sDisease

  2022cites this paper
• Why the Ala-His-His Peptide Is an Appropriate Scaffold to Remove and Redox Silence Copper Ions from the Alzheimer’s-Related Aβ Peptide

  2022cites this paper
• Inhibition of Alzheimer's Aβ1‐42 Fibrillogenesis and Removal of Copper Ions by Polypeptides Modified Gold Nanoparticles

  2022cites this paper
• Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models

  2022cites this paper
• Curcumin ligand based iridium(III) complexes as inhibition and visualization agent of beta-amyloid fibrillation

  2021cites this paper
• Novel sampangine derivatives as potent inhibitors of Cu2+-mediated amyloid-β protein aggregation, oxidative stress and inflammation.

  2021cites this paper
• Effects of food-derived bioactive peptides on cognitive deficits and memory decline in neurodegenerative diseases: A review

  2021cites this paper
• His-Rich Peptides, Gly- and His-Rich Peptides: Functionally Versatile Compounds with Potential Multi-Purpose Applications

  2021cites this paper
• Conjugation of RTHLVFFARK to human lysozyme creates a potent multifunctional modulator for Cu2+-mediated amyloid β-protein aggregation and cytotoxicity.

  2020cites this paper
• The essential elements of Alzheimer’s disease

  2020cites this paper
• A copper complex formed with neurokinin B: binding stoichiometry, redox properties, self-assembly and cytotoxicity.

  2020cites this paper
• N-truncated Aβ peptides impact on Cu and Cu(Aβ)-generated ROS: Cu(I) matters !

  2020cites this paper
• Inhibitory Potency of 4- Substituted Sampangine Derivatives toward Cu2+ mediated aggregation of amyloid β-peptide, Oxidative Stress, and Inflammation in Alzheimer's Disease.

  2020cites this paper
• Neutralization of Reactive Oxygen Species at Dinuclear Cu(II)-Cores: Tuning the Antioxidant Manifold in Water by Ligand Design

  2020cites this paper
• Activation Effects of Carnosine- and Histidine-Containing Dipeptides on Human Carbonic Anhydrases: A Comprehensive Study

  2020cites this paper
• Self-triggered click reaction in an Alzheimer's disease model: in situ bifunctional drug synthesis catalyzed by neurotoxic copper accumulated in amyloid-β plaques

  2019cites this paper
• Peptidic Scaffolds To Reduce the Interaction of Cu(II) Ions with β-Amyloid Protein.

  2019cites this paper
• Recent advances in the design and applications of amyloid-β peptide aggregation inhibitors for Alzheimer’s disease therapy

  2019cites this paper
• Detection of Cu2+ Ions with GGH Peptide Realized with Si-Nanoribbon ISFET

  2019cites this paper
• Copper-Targeting Approaches in Alzheimer's Disease: How To Improve the Fallouts Obtained from in Vitro Studies.

  2019cites this paper
• Intracellular Fenton reaction based on mitochondria-targeted copper(ii)–peptide complex for induced apoptosis

  2019cites this paper
• d-Enantiomeric RTHLVFFARK-NH2: A Potent Multifunctional Decapeptide Inhibiting Cu2+-Mediated Amyloid β-Protein Aggregation and Remodeling Cu2+-Mediated Amyloid β Aggregates.

  2019cites this paper
• Nitration of amyloid-β peptide (1-42) as a protective mechanism for the amyloid-β peptide (1-42) against copper ion toxicity.

  2019cites this paper
• Pharmacodynamics in Alzheimer's disease model rats of a bifunctional peptide with the potential to accelerate the degradation and reduce the toxicity of amyloid β-Cu fibrils.

  2018cites this paper
• Interaction of Amyloid Aβ(9–16) Peptide Fragment with Metal Ions: CD, FT-IR, and Fluorescence Spectroscopic Studies

  2018cites this paper
• Synthesis of Histidine-Containing Oligopeptides via Histidine-Promoted Peptide Ligation.

  2018cites this paper
• Design of nonapeptide LVFFARKHH: A bifunctional agent against Cu2+‐mediated amyloid β‐protein aggregation and cytotoxicity

  2018cites this paper
• Carnosine-LVFFARK-NH2 Conjugate: A Moderate Chelator but Potent Inhibitor of Cu2+-Mediated Amyloid β-Protein Aggregation.

  2018cites this paper
• Nouvelles preuves de concept pour la chélatothérapie contre la maladie d'Alzheimer : études spectroscopiques des interactions entre les ions cuivre et zinc

  2017cites this paper
• Hybrid Antioxidant and Metal Sequestering Small Molecules Targeting the Molecular Features of Alzheimer’s Disease

  2017cites this paper
• Similarities and differences of copper and zinc cations binding to biologically relevant peptides studied by vibrational spectroscopies

  2017cites this paper
• A Trishistidine Pseudopeptide with Ability to Remove Both CuΙ and CuΙΙ from the Amyloid-β Peptide and to Stop the Associated ROS Formation.

  2017cites this paper