How to fold intricately: using theory and experiments to unravel the properties of knotted proteins.

Over the years, advances in experimental and computational methods have helped us to understand the role of thermodynamic, kinetic and active (chaperone-aided) effects in coordinating the folding steps required to achieving a knotted native state. Here, we review such developments by paying particular attention to the complementarity of experimental and computational studies. Key open issues that could be tackled with either or both approaches are finally pointed out.

• Publication year

  2016

• Venue

  Current Opinion in Structural Biology

• Publication date

  2016-10-18

• Fields of study

  Biology, Physics, Chemistry, Computer Science, Medicine

• Identifiers
  DOI 10.1016/j.sbi.2016.10.002arXiv 1610.05779PMID 27794211
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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