HIV-1 Nef protein expression in human CD34+ progenitors impairs the differentiation of an early T/NK cell precursor.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Virology

• Publication date

  2008-07-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.virol.2008.04.009PMID 18555888
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells.

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• HIV-1 Nef Binds the DOCK2–ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis

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• The Effects of HIV-1 Nef on CD4 Surface Expression and Viral Infectivity in Lymphoid Cells Are Independent of Rafts*

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• Human Immunodeficiency Virus Type 1 Nef-Mediated Downregulation of CD4 Correlates with Nef Enhancement of Viral Pathogenesis

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• Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators.

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• Evidence for Increased T Cell Turnover and Decreased Thymic Output in HIV Infection1

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• The Pathogenicity of Human Immunodeficiency Virus (HIV) Type 1 Nef in CD4C/HIV Transgenic Mice Is Abolished by Mutation of Its SH3-Binding Domain, and Disease Development Is Delayed in the Absence of Hck

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• HIV-1 Nef impairs MHC class II antigen presentation and surface expression

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• Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway.

  1999cited by this paper
• HIV-1 Nef increases T cell activation in a stimulus-dependent manner.

  1999cited by this paper
• Inhibition of Thymopoiesis of CD34+ Cell Maturation by HIV‐1 in an In Vitro CD34+ Cell and Thymic Epithelial Organ Culture Model

  1999cited by this paper
• Induction of Fas Ligand Expression by HIV Involves the Interaction of Nef with the T Cell Receptor ζ Chain

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• Transgenic Mice Expressing Human Immunodeficiency Virus Type 1 in Immune Cells Develop a Severe AIDS-Like Disease

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• Peripheral blood-derived CD34+ progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIV.

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• CXCR4 and CCR5 expression delineates targets for HIV-1 disruption of T cell differentiation.

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• Expression of the human immunodeficiency virus type-1 coreceptors CXCR-4 (fusin, LESTR) and CKR-5 in CD34+ hematopoietic progenitor cells.

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• HIV-1-induced thymocyte depletion is associated with indirect cytopathogenicity and infection of progenitor cells in vivo.

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• CD34+ progenitor cells from asymptomatic patients are not a major reservoir for human immunodeficiency virus-1.

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• A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection.

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• CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.

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• Altered T cell activation and development in transgenic mice expressing the HIV‐1 nef gene.

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• HIV induces thymus depletion in vivo

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• CD34+ bone marrow cells are infected with HIV in a subset of seropositive individuals.

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• Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

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• Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

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• Alternative splice acceptor utilization during human immunodeficiency virus type 1 infection of cultured cells

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• Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages

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• CD34+ hematopoietic progenitor cells are not a major reservoir of the human immunodeficiency virus.

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