Synthetic biology, genome mining, and combinatorial biosynthesis of NRPS-derived antibiotics: a perspective

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Journal of Industrial Microbiology & Biotechnology

• Publication date

  2018-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s10295-017-1999-8PMID 29288438
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Erratum: Visualizing detailed postdoctoral employment trends using a new career outcome taxonomy

  2018cited by this paper
• Synthetic biology of polyketide synthases

  2018cited by this paper
• SANDPUMA: ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across Actinobacteria

  2017cited by this paper
• Microbial Genome Mining for Natural Product Drug Discovery

  2017cited by this paper
• Microbial Genome Mining for Natural Product Drug Discovery

  2017influential reference
• 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life

  2017cited by this paper
• antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification

  2017cited by this paper
• Gifted microbes for genome mining and natural product discovery

  2017cited by this paper
• A plug‐and‐play pathway refactoring workflow for natural product research in Escherichia coli and Saccharomyces cerevisiae

  2017cited by this paper
• Nonribosomal Peptide Synthesis-Principles and Prospects.

  2017cited by this paper
• Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture*

  2016cited by this paper
• A structural model for multimodular NRPS assembly lines.

  2016cited by this paper
• Biochemical Dissection of the Natural Diversification of Microcystin Provides Lessons for Synthetic Biology of NRPS.

  2016cited by this paper
• Synthetic biology to access and expand nature's chemical diversity

  2016cited by this paper
• Cracking the Nonribosomal Code.

  2016cited by this paper
• Generating Functional Recombinant NRPS Enzymes in the Laboratory Setting via Peptidyl Carrier Protein Engineering.

  2016cited by this paper
• Natural product discovery: past, present, and future

  2016cited by this paper
• Harnessing natural product assembly lines: structure, promiscuity, and engineering

  2016cited by this paper
• Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes

  2016cited by this paper
• Next Generation Sequencing of Actinobacteria for the Discovery of Novel Natural Products

  2016cited by this paper
• Interdomain and Intermodule Organization in Epimerization Domain Containing Nonribosomal Peptide Synthetases.

  2016cited by this paper
• Mapping of the Communication-Mediating Interface in Nonribosomal Peptide Synthetases Using a Genetically Encoded Photocrosslinker Supports an Upside-Down Helix-Hand Motif.

  2016cited by this paper
• Natural Products as Sources of New Drugs from 1981 to 2014.

  2016cited by this paper
• Structural insight into the necessary conformational changes of modular nonribosomal peptide synthetases.

  2016cited by this paper
• Recent advances in engineering nonribosomal peptide assembly lines.

  2016cited by this paper
• Structural Biology of Nonribosomal Peptide Synthetases.

  2016cited by this paper
• Reinvigorating natural product combinatorial biosynthesis with synthetic biology.

  2015cited by this paper
• Structures of Two Distinct Conformations of holo-Nonribosomal Peptide Synthetases

  2015cited by this paper
• antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

  2015cited by this paper
• The Streptomyces leeuwenhoekii genome: de novo sequencing and assembly in single contigs of the chromosome, circular plasmid pSLE1 and linear plasmid pSLE2

  2015cited by this paper
• The structural biology of biosynthetic megaenzymes.

  2015cited by this paper
• A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis

  2014influential reference
• Draft Genome Sequence of Streptomyces fradiae ATCC 19609, a Strain Highly Sensitive to Antibiotics

  2014cited by this paper
• Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

  2014influential reference
• Combinatorial biosynthesis of cyclic lipopeptide antibiotics: a model for synthetic biology to accelerate the evolution of secondary metabolite biosynthetic pathways.

  2014influential reference
• Importance of microbial natural products and the need to revitalize their discovery

  2014cited by this paper
• Natural product and natural product derived drugs in clinical trials.

  2014cited by this paper
• Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

  2014cited by this paper
• Microbial natural products: molecular blueprints for antitumor drugs

  2013cited by this paper
• Evolution-guided engineering of nonribosomal peptide synthetase adenylation domains

  2013cited by this paper
• Synthetic biology.

  2012cited by this paper
• Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology.

  2012cited by this paper
• NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

  2011cited by this paper
• Production of novel lipopeptide antibiotics related to A54145 by Streptomyces fradiae mutants blocked in biosynthesis of modified amino acids and assignment of lptJ, lptK and lptL gene functions

  2011cited by this paper
• Structural characterization of a lipopeptide antibiotic A54145E(Asn3Asp9) produced by a genetically engineered strain of Streptomyces fradiae

  2011cited by this paper
• Molecular cloning and identification of the laspartomycin biosynthetic gene cluster from Streptomyces viridochromogenes.

  2011cited by this paper
• Genome Sequence of the Spinosyns-Producing Bacterium Saccharopolyspora spinosa NRRL 18395

  2011cited by this paper
• Genomics and the ancient origins of the daptomycin biosynthetic gene cluster

  2010influential reference
• Daptomycin: from the mountain to the clinic, with essential help from Francis Tally, MD.

  2010cited by this paper
• Genetically Engineered Lipopeptide Antibiotics Related to A54145 and Daptomycin with Improved Properties

  2010cited by this paper
• Development of a Genetic System for Combinatorial Biosynthesis of Lipopeptides in Streptomyces fradiae and Heterologous Expression of the A54145 Biosynthesis Gene Cluster

  2010cited by this paper
• Nonribosomal peptide synthetases: structures and dynamics.

  2010cited by this paper
• Genomic basis for natural product biosynthetic diversity in the actinomycetes.

  2009cited by this paper
• Complete genome sequence of Saccharomonospora viridis type strain (P101T)

  2009cited by this paper
• Daptomycin: mechanisms of action and resistance, and biosynthetic engineering.

  2009cited by this paper
• Control of tylosin biosynthesis in Streptomyces fradiae.

  2008cited by this paper
• Renaissance in antibacterial discovery from actinomycetes.

  2008cited by this paper
• Non-ribosomal peptide synthetase module fusions to produce derivatives of daptomycin in Streptomyces roseosporus.

  2008cited by this paper
• Biosynthesis and genetic engineering of lipopeptide antibiotics related to daptomycin.

  2008influential reference
• Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans

  2007cited by this paper
• Sequencing and Analysis of the Biosynthetic Gene Cluster of the Lipopeptide Antibiotic Friulimicin in Actinoplanes friuliensis

  2007cited by this paper
• Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes

  2007cited by this paper
• Mutations in clusters and showers

  2007cited by this paper
• Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics.

  2006cited by this paper
• The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae

  2006cited by this paper
• Combinatorial biosynthesis of novel antibiotics related to daptomycin

  2006cited by this paper
• Biosynthesis of the (2S,3R)-3-methyl glutamate residue of nonribosomal lipopeptides.

  2006cited by this paper
• A glutamic acid 3‐methyltransferase encoded by an accessory gene locus important for daptomycin biosynthesis in Streptomyces roseosporus

  2006cited by this paper
• Complementation of daptomycin dptA and dptD deletion mutations in trans and production of hybrid lipopeptide antibiotics.

  2006cited by this paper
• Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry.

  2005influential reference
• Natural products to drugs: daptomycin and related lipopeptide antibiotics.

  2005cited by this paper
• Clusters of mutations from transient hypermutability.

  2005cited by this paper
• Synthesis and biological activity of N-Acylated ornithine analogues of daptomycin.

  2003cited by this paper
• Array synthesis of novel lipodepsipeptide.

  2003cited by this paper
• Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.

  2002cited by this paper
• Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.

  2001cited by this paper
• Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains.

  2000cited by this paper
• The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases.

  1999cited by this paper
• Molecular Cloning and Physical Mapping of the Daptomycin Gene Cluster from Streptomyces roseosporus

  1998cited by this paper
• Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis.

  1997cited by this paper
• Mutants of Streptomyces roseosporus that express enhanced recombination within partially homologous genes.

  1996cited by this paper
• Gene transfer and transposition mutagenesis in Streptomyces roseosporus: mapping of insertions that influence daptomycin or pigment production.

  1996cited by this paper
• A54145, a new lipopeptide antibiotic complex: discovery, taxonomy, fermentation and HPLC.

  1990influential reference
• Basic local alignment search tool.

  1990cited by this paper
• Enzymatic and chemical modifications of lipopeptide antibiotic A21978C: the synthesis and evaluation of daptomycin (LY146032).

  1988cited by this paper
• The biochemistry of mutagenesis.

  1976cited by this paper

• Combinatorial Nonribosomal Peptide Synthetase Libraries Using the SEAM-Combi-OGAB Method.

  2025cites this paper
• Human gut microbiota-derived antimicrobials against Salmonella Typhi: diversity, mechanisms, and therapeutic potential

  2025cites this paper
• The encoded and expressed biosynthetic potential of Greenland Ice Sheet microbes

  2025cites this paper
• A Review on Lipopeptide Production, Structural Characterization, and Its Applications

  2025cites this paper
• Daptomycin: Mechanism of action, mechanisms of resistance, synthesis and structure-activity relationships.

  2025cites this paper
• In-Situ Purification of Non-Ribosomal Peptide Synthetases Assembly Line for Structural and Biochemical Studies

  2025cites this paper
• Engineering of the start condensation domain with improved N‐decanoyl catalytic activity for daptomycin biosynthesis

  2024cites this paper
• Expanding the Substrate Selectivity of the Fimsbactin Biosynthetic Adenylation Domain, FbsH

  2024cites this paper
• Regulation of daptomycin biosynthesis in Streptomyces roseosporus: new insights from genomic analysis and synthetic biology to accelerate lipopeptide discovery and commercial production.

  2024cites this paper
• Expanding the substrate selectivity of the fimsbactin biosynthetic adenylation domain, FbsH

  2024cites this paper
• Substitution of the communication-mediating domain and the interaction between modules in bacillomycin D produced by Bacillus amyloliquefaciens

  2023cites this paper
• Digital Sequence Information on Genetic Resources and the Convention on Biological Diversity

  2022cites this paper
• Structural diversity, biosynthesis, and biological functions of lipopeptides from Streptomyces.

  2022cites this paper
• Novel species of Frankia, Frankia gtarii sp. nov. and Frankia tisai sp. nov., isolated from a root nodule of Alnus glutinosa.

  2022cites this paper
• Proof-Reading Thioesterase Boosts Activity of Engineered Nonribosomal Peptide Synthetase

  2022cites this paper
• Available strategies for improving the biosynthesis of surfactin: a review

  2022cites this paper
• Deletion of COM donor and acceptor domains and the interaction between modules in bacillomycin D produced by Bacillus amyloliquefaciens

  2022influential citation
• Combinatorial biosynthesis: playing chess with the metabolism

  2022cites this paper
• Multi-Omics Data Mining: A Novel Tool for BioBrick Design

  2022cites this paper
• Genome mining for drug discovery: cyclic lipopeptides related to daptomycin

  2021influential citation
• Natural Products, the Fourth Industrial Revolution, and the Quintuple Helix

  2021cites this paper
• Biodegradation of Hydrophobic Polycyclic Aromatic Hydrocarbons

  2021cites this paper
• Genome mining for drug discovery: progress at the front end

  2021cites this paper
• Activation of cryptic milbemycin A 4 production in Streptomyces sp. BB47 by the introduction of a functional bldA gene

  2021cites this paper
• Actinobacteria From Desert: Diversity and Biotechnological Applications

  2021influential citation
• Activation of cryptic milbemycin A4 production in Streptomyces sp. BB47 by the introduction of a functional bldA gene.

  2021cites this paper
• Pleiotropic regulation of daptomycin synthesis by DptR1, a LuxR family transcriptional regulator

  2020cites this paper
• An Update on Molecular Tools for Genetic Engineering of Actinomycetes—The Source of Important Antibiotics and Other Valuable Compounds

  2020cites this paper
• Pleiotropic regulation of daptomycin synthesis by DptR1, a LuxR family transcriptional regulator

  2020cites this paper
• Efficient rational modification of non-ribosomal peptides by adenylation domain substitution

  2020cites this paper
• Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases.

  2020cites this paper
• Engineering biosynthetic enzymes for industrial natural product synthesis.

  2020cites this paper
• Control of the polymyxin analog ratio by domain swapping in the nonribosomal peptide synthetase of Paenibacillus polymyxa

  2020cites this paper
• Antimicrobial peptides, an alternative to combat bacterial resistance

  2020cites this paper
• Emerging evolutionary paradigms in antibiotic discovery

  2019cites this paper
• Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil

  2019cites this paper
• Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities

  2019cites this paper
• Modelling the variable incorporation of aromatic amino acids in the tyrocidines and analogous cyclodecapeptides

  2019cites this paper
• Biological, chemical, and biochemical strategies for modifying glycopeptide antibiotics

  2019cites this paper
• Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products

  2019cites this paper
• Modular and Integrative Vectors for Synthetic Biology Applications in Streptomyces spp

  2019cites this paper
• Marine Biosurfactants: Biosynthesis, Structural Diversity and Biotechnological Applications

  2019cites this paper
• Antarctic Streptomyces fildesensis So13.3 strain as a promising source for antimicrobials discovery

  2019cites this paper
• Natural products from anaerobes

  2019cites this paper
• Streptomyces as a Source of Antimicrobials: Novel Approaches to Activate Cryptic Secondary Metabolite Pathways

  2019cites this paper
• Bioprospecting in Cuatro Cienegas: A Set of Open Possibilities to Save the Ecosystem

  2018cites this paper
• Cuatro Ciénegas Ecology, Natural History and Microbiology

  2018cites this paper
• Structural, functional and evolutionary perspectives on effective re-engineering of non-ribosomal peptide synthetase assembly lines.

  2018cites this paper
• Synthetic biology advances and applications in the biotechnology industry: a perspective

  2018influential citation
• Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases

  2018cites this paper
• Streptomyces Differentiation in Liquid Cultures as a Trigger of Secondary Metabolism

  2018cites this paper
• Hidden antibiotics: Where to uncover?

  2018cites this paper