Prognostic implications of DNA aneuploidy in 156 untreated multiple myeloma patients

No abstract is available for this paper.

• Publication year

  1995

• Venue

  British Journal of Haematology

• Publication date

  1995-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-2141.1995.tb03387.xPMID 7786771
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A new method for the analysis of plasma cell DNA content in multiple myeloma samples using a CD38/propidium iodide double staining technique.

  1994cited by this paper
• Consensus review of the clinical utility of DNA flow cytometry in neoplastic hematopathology.

  1993cited by this paper
• DNA cytometry consensus conference.

  1993cited by this paper
• Guidelines for implementation of clinical DNA cytometry. International Society for Analytical Cytology.

  1993cited by this paper
• Alternating combination VCMP/VBAP chemotherapy versus melphalan/prednisone in the treatment of multiple myeloma: a randomized multicentric study of 487 patients.

  1993cited by this paper
• Immunophenotype and DNA content of myeloma cells in primary plasma cell leukemia

  1992cited by this paper
• The biological and clinical significance of the KI‐67 growth fraction in multiple myeloma

  1992cited by this paper
• Flow cytometric DNA analysis and clinical correlations in multiple myeloma.

  1992cited by this paper
• Lymphoid subsets and prognostic factors in multiple myeloma

  1992cited by this paper
• Immunophenotypic heterogeneity of multiple myeloma: influence on the biology and clinical course of the disease

  1991cited by this paper
• DNA and RNA flow cytometric study in multiple myeloma. Clinical correlations

  1991cited by this paper
• Ras oncogene expression and DNA content in plasma cell dyscrasias: a flow cytofluorimetric study.

  1990cited by this paper
• Plasma cells in multiple myeloma express a natural killer cell-associated antigen: CD56 (NKH-1; Leu-19).

  1990cited by this paper
• Plasma cells in multiple myeloma express a natural killer cell- associated antigen: CD56 (NKH-1; Leu-19)

  1990cited by this paper
• SPSS base system user's guide

  1990cited by this paper
• Myelomonocytic antigen positive multiple myeloma.

  1989cited by this paper
• Detection of hypodiploidy using multi‐parameter flow cytometric analysis: A prognostic indicator in multiple myeloma

  1989cited by this paper
• Myelomonocytic Antigen Positive Multiple Myeloma

  1989cited by this paper
• Biclonal and hypodiploid multiple myeloma.

  1986cited by this paper
• Prognostic implications of tumor cell DNA and RNA content in multiple myeloma.

  1985cited by this paper
• Limits of detection of nuclear DNA abnormalities by flow cytometric DNA analysis. Results obtained by a set of methods for sample-storage, staining and internal standardization.

  1983cited by this paper
• Ploidy and proliferative characteristics in monoclonal gammopathies.

  1982cited by this paper
• Flow cytometric analysis of DNA content of bone marrow cells in patients with plasma cell myeloma: clinical implications.

  1982cited by this paper
• Cellular DNA content as a marker of human multiple myeloma.

  1980cited by this paper
• A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival

  1975cited by this paper
• Radiation therapy for cancer of the lung: previous experience and definition of current issues.

  1973cited by this paper

• Somatic Genomic Mosaicism in Multiple Myeloma

  2020cites this paper
• Rapid assessment of hyperdiploidy in plasma cell disorders using a novel multi‐parametric flow cytometry method

  2019cites this paper
• Philadelphia-positive case negative for JAK2 V617F mutation with hyperdiploidic karyotype: A case report.

  2019cites this paper
• Current applications of multiparameter flow cytometry in plasma cell disorders

  2018cites this paper
• Quantitative PCR: an alternative approach to detect common copy number alterations in multiple myeloma

  2017cites this paper
• Current applications of multiparameter flow cytometry in plasma cell disorders

  2017cites this paper
• A Next-Generation Sequencing Strategy for Evaluating the Most Common Genetic Abnormalities in Multiple Myeloma.

  2017cites this paper
• A novel and easy FxCycle™ violet based flow cytometric method for simultaneous assessment of DNA ploidy and six‐color immunophenotyping

  2016cites this paper
• The flow cytometry-defined light chain cytoplasmic immunoglobulin index and an associated 12-gene expression signature are independent prognostic factors in multiple myeloma

  2015cites this paper
• Immunophenotypic features by multiparameter flow cytometry can help distinguish low grade B‐cell lymphomas with plasmacytic differentiation from plasma cell proliferative disorders with an unrelated clonal B‐cell process

  2015cites this paper
• Defining and treating high-risk multiple myeloma

  2015cites this paper
• Estudio de ploidía de células plasmáticas por citometría de flujo en pacientes con mieloma múltiple: primeros casos estudiados en Uruguay

  2013cites this paper
• nonhyperdiploid dichotomy in MGUS A validated FISH trisomy index demonstrates the hyperdiploid and

  2013cites this paper
• Evaluating gene expression profiling by quantitative polymerase chain reaction to develop a clinically feasible test for outcome prediction in multiple myeloma

  2013cites this paper
• Genomic Strategies Determining Progression from MGUS to Multiple Myeloma

  2013cites this paper
• Prognosis and Staging of Multiple Myeloma

  2013cites this paper
• non-hyperdiploid variant multiple myeloma The recurrent IgH translocations are highly associated with

  2013cites this paper
• followed by maintenance myeloma patients receiving short induction with weekly bortezomib Outcome according to cytogenetic abnormalities and DNA ploidy in

  2012cites this paper
• Outcome according to cytogenetic abnormalities and DNA ploidy in myeloma patients receiving short induction with weekly bortezomib followed by maintenance.

  2011cites this paper
• Hyperdiploidy is less frequent in AL amyloidosis compared with monoclonal gammopathy of undetermined significance and inversely associated with translocation t(11;14).

  2011cites this paper
• Plasma cell leukemia.

  2011cites this paper
• Anormalidades citogenéticas e sua relação com a proliferação e a apoptose celular em portadores de mieloma múltiplo

  2010cites this paper
• Utility of flow cytometry immunophenotyping in multiple myeloma and other clonal plasma cell‐related disorders

  2010cites this paper
• Risk Stratification in the Era of Novel Therapies

  2009cites this paper
• Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines.

  2009cites this paper
• Low expression of ZHX2, but not RCBTB2 or RAN, is associated with poor outcome in multiple myeloma

  2008cites this paper
• Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders

  2008cites this paper
• Pathologic studies useful for the diagnosis and monitoring of plasma cell dyscrasias.

  2007cites this paper
• Targeted therapeutics for multiple myeloma: The arrival of a risk-stratified approach

  2007cites this paper
• Hyperdiploidy Is a Common Finding in Monoclonal Gammopathy of Undetermined Significance and Monosomy 13 Is Restricted to These Hyperdiploid Patients

  2007cites this paper
• A practical guide to defining high-risk myeloma for clinical trials, patient counseling and choice of therapy

  2007cites this paper
• Review of molecular diagnostics in multiple myeloma

  2007cites this paper
• Abnormalities of chromosome 1p/q are highly associated with chromosome 13/13q deletions and are an adverse prognostic factor for the outcome of high‐dose chemotherapy in patients with multiple myeloma

  2007cites this paper
• Prognostic factors and staging in multiple myeloma.

  2007cites this paper
• Individualizing therapy using molecular markers in multiple myeloma.

  2007cites this paper
• New Genetic Insights and Therapy in Multiple Myeloma

  2007cites this paper
• Conventional diagnostics in multiple myeloma.

  2006cites this paper
• Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma

  2006cites this paper
• Chromosomal aberrations in 130 patients with multiple myeloma studied by interphase FISH: diagnostic and prognostic relevance.

  2006cites this paper
• Flow cytometric analysis of lymphomas: current status and usefulness.

  2006cites this paper
• Prognostic significance of plasma cell propidium iodide and annexin-V indices and their mutual ratio in multiple myeloma.

  2006cites this paper
• Prognostic factors for hyperdiploid-myeloma: effects of chromosome 13 deletions and IgH translocations

  2006cites this paper
• Cell cycle analysis of Waldenstrom's macroglobulinemia.

  2005cites this paper
• Prognostic features of multiple myeloma.

  2005cites this paper
• Genetic Abnormalities and Patterns of Antigenic Expression in Multiple Myeloma

  2005cites this paper
• A validated FISH trisomy index demonstrates the hyperdiploid and nonhyperdiploid dichotomy in MGUS.

  2005cites this paper
• Mieloma Múltiplo: 50 casos diagnosticados por citometria de fluxo

  2005cites this paper
• Flow cytometric detection of aneuploid CD38(++) plasmacells and CD19(+) B-lymphocytes in bone marrow, peripheral blood and PBSC harvest in multiple myeloma patients.

  2004cites this paper
• Chromosome 13 Deletion/Hypodiploidy and Prognosis in Multiple Myeloma Patients

  2004cites this paper
• Innovative approaches for diagnosis and monitoring

  2004cites this paper
• Proliferative activity of plasma cells is the most relevant prognostic factor in elderly multiple myeloma patients

  2004cites this paper
• Frequent gains of the short arm of chromosome 9 in multiple myeloma with normal G-banded karyotype detected by comparative genomic hybridization.

  2004cites this paper
• The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma.

  2003cites this paper
• Predicting Long-term Survival in Multiple Myeloma Patients Following Autotransplants

  2003cites this paper
• Mujer de 74 años con dolor en la ingle derecha y osteólisis craneal

  2003cites this paper
• Mycophenolate mofetil increases adhesion capacity of tumor cells in vitro1

  2003cites this paper
• Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma

  2003cites this paper
• [Pain at the right groin and cranial osteolysis in a 74-year-old woman].

  2003cites this paper
• Both hypodiploidy and deletion of chromosome 13 independently confer poor prognosis in multiple myeloma

  2002cites this paper
• Intensive therapy in multiple myeloma

  2002cites this paper
• Hypodiploidy is a major prognostic factor in multiple myeloma.

  2001cites this paper
• Simultaneous detection of multiple genetic aberrations in single cells by spectral fluorescence in situ hybridization.

  2001cites this paper
• Advances in Brief Simultaneous Detection of Multiple Genetic Aberrations in Single Cells by Spectral Fluorescence in Situ Hybridization 1

  2001cites this paper
• Carcinoembryonic antigen elevation in agnogenic myeloid metaplasia

  2000cites this paper
• CARCINOEMBRYONIC ANTIGEN ELEVATION IN AGNOGENIC MYELOID METAPLASIA

  2000cites this paper
• Immunophenotypic aberrations, DNA content, and cell cycle analysis of plasma cells in patients with myeloma and monoclonal gammopathies.

  2000cites this paper
• Reply to Nowak et al

  2000cites this paper
• In multiple myeloma, circulating hyperdiploid B cells have clonotypic immunoglobulin heavy chain rearrangements and may mediate spread of disease.

  2000cites this paper
• Correlation between cytogenetic abnormalities and disease characteristics in multiple myeloma: monosomy of chromosome 13 and structural abnormalities of 11q are associated with a high percentage of S-phase plasma cells.

  2000cites this paper
• Drug resistance in multiple myeloma: novel therapeutic targets within the malignant clone.

  1999cites this paper
• Distribution of myeloma plasma cells in peripheral blood and bone marrow correlates with CD56 expression

  1999cites this paper
• Is flow cytometric DNA content hypodiploidy prognostic in multiple myeloma?

  1999cites this paper
• Primary plasma cell leukemia: clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics.

  1999cites this paper
• Immunophenotypic and DNA content characteristics of plasma cells in multiple myeloma and monoclonal gammopathy of undetermined significance.

  1999cites this paper
• IL‐4 improves the detection of cytogenetic abnormalities in multiple myeloma and increases the proportion of clonally abnormal metaphases

  1998cites this paper
• The incidence of DNA aneuploidy in multiple myeloma does not correlate with stage of disease.

  1998cites this paper
• Chromosomal analysis in multiple myeloma: cytogenetic evidence of two different diseases

  1998cites this paper
• Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes.

  1998cites this paper
• DNA Aneuploidy by Flow Cytometry Is an Independent Prognostic Factor in Gastric Cancer

  1998cites this paper
• A study of c-myc translational regulation in multiple myeloma

  1997cites this paper
• Membrane CD22 defines circulating myeloma-related cells as mature or later B cells.

  1997cites this paper
• Hypodiploidy and 22q11 rearrangements at diagnosis are associated with poor prognosis in patients with multiple myeloma

  1997cites this paper
• Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: Primary breakpoints and clinical correlations

  1997cites this paper
• THE USE OF BIOLOGICAL VARIABLES TO PREDICT OUTCOME IN MULTIPLE MYELOMA

  1997cites this paper
• DNA cell content studies in multiple myeloma.

  1996cites this paper
• Tumor-specific aneuploidy not detected in CD19+ B-lymphoid cells from myeloma patients in a multidimensional flow cytometric analysis.

  1996cites this paper
• MULTIPLE MYELOMA: ALMOST ALL PATIENTS ARE CYTOGENETICALLY ABNORMAL

  1996cites this paper
• Incidence of chromosome numerical changes in multiple myeloma: fluorescence in situ hybridization analysis using 15 chromosome-specific probes.

  1996cites this paper
• Flow cytometry in the diagnosis of cancer.

  1995cites this paper
• Immunophenotype and DNA cell content in multiple myeloma.

  1995cites this paper