A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α2-Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to Neurodegeneration Ex Vivo and In Vivo

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Molecular and Cellular Biology

• Publication date

  2015-07-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.00544-15PMID 26217017PMCID PMC4561734
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation

  2014cited by this paper
• IGF binding proteins in cancer: mechanistic and clinical insights

  2014cited by this paper
• Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1

  2013cited by this paper
• LRP1 Assembles Unique Co-receptor Systems to Initiate Cell Signaling in Response to Tissue-type Plasminogen Activator and Myelin-associated Glycoprotein*

  2013cited by this paper
• Proprotein convertase furin enhances survival and migration of vascular smooth muscle cells via processing of pro-nerve growth factor.

  2013cited by this paper
• ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice

  2013cited by this paper
• ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation

  2012cited by this paper
• Etanercept, a Widely Used Inhibitor of Tumor Necrosis Factor-α (TNF- α), Prevents Retinal Ganglion Cell Loss in a Rat Model of Glaucoma

  2012cited by this paper
• During glaucoma, alpha2-macroglobulin accumulates in aqueous humor and binds to nerve growth factor, neutralizing neuroprotection.

  2011cited by this paper
• ProNGF induces TNFα-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway

  2010cited by this paper
• An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma.

  2010cited by this paper
• Chronic and Acute Models of Retinal Neurodegeneration TrkA Activity Are Neuroprotective whereas p75NTR Activity Is Neurotoxic through a Paracrine Mechanism*

  2010cited by this paper
• A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist.

  2010cited by this paper
• A neurotrophic rationale for the therapy of neurodegenerative disorders.

  2009cited by this paper
• Biological Activity of Nerve Growth Factor Precursor Is Dependent upon Relative Levels of Its Receptors*

  2009cited by this paper
• Excitotoxic Death of Retinal Neurons In Vivo Occurs via a Non-Cell-Autonomous Mechanism

  2009cited by this paper
• Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor.

  2008cited by this paper
• α2-Macroglobulin Is a Mediator of Retinal Ganglion Cell Death in Glaucoma*

  2008cited by this paper
• Neurotrophic rationale in glaucoma: A TrkA agonist, but not NGF or a p75 antagonist, protects retinal ganglion cells in vivo

  2007cited by this paper
• Effect of retinal laser photocoagulation on the activity of metalloproteinases and the alpha(2)-macroglobulin proteolytic state in the vitreous of eyes with proliferative diabetic retinopathy.

  2007cited by this paper
• Low-density lipoprotein receptor-related protein-1 (LRP-1) expression in a rat model of oxygen-induced retinal neovascularization.

  2006cited by this paper
• Interaction of Survival and Death Signaling in Basal Forebrain Neurons: Roles of Neurotrophins and Proneurotrophins

  2006cited by this paper
• Construction of a mutated pro-nerve growth factor resistant to degradation and suitable for biophysical and cellular utilization

  2006cited by this paper
• Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition.

  2005cited by this paper
• ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin

  2005cited by this paper
• The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor

  2004cited by this paper
• Brain capillary endothelial cells proliferate in response to NGF, express NGF receptors and secrete NGF after inflammation.

  2004cited by this paper
• An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells.

  2004cited by this paper
• Differential cross-regulation of TrkA and TrkC tyrosine kinase receptors with p75

  2003cited by this paper
• Low‐density lipoprotein receptor‐related protein mediates in PC12 cell cultures the inhibition of nerve growth factor‐promoted neurite outgrowth by pregnancy zone protein and α2‐macroglobulin

  2002cited by this paper
• Comparative binding of biotinylated neurotrophins to α2‐macroglobulin family of proteins: Relationship between cytokine‐binding and neuro‐modulatory activities of the macroglobulins

  2002cited by this paper
• Low-density lipoprotein receptor-related protein mediates in PC12 cell cultures the inhibition of nerve growth factor-promoted neurite outgrowth by pregnancy zone protein and alpha2-macroglobulin.

  2002cited by this paper
• Regulation of Cell Survival by Secreted Proneurotrophins

  2001cited by this paper
• Role of α2‐macroglobulin in regulating amyloid β‐protein neurotoxicity: protective or detrimental factor?

  2001cited by this paper
• Role of alpha2-macroglobulin in regulating amyloid beta-protein neurotoxicity: protective or detrimental factor?

  2001cited by this paper
• p75 Co-receptors Regulate Ligand-dependent and Ligand-independent Trk Receptor Activation, in Part by Altering Trk Docking Subdomains*

  2001cited by this paper
• Cell signaling by receptor tyrosine kinases.

  2000cited by this paper
• Cell signaling by receptor tyrosine kinases.

  2000cited by this paper
• alpha2-macroglobulin in late-onset Alzheimer's disease.

  2000cited by this paper
• α2-Macroglobulin in late-onset Alzheimer's disease

  2000cited by this paper
• A designed peptidomimetic agonistic ligand of TrkA nerve growth factor receptors.

  2000cited by this paper
• Functional Blockade of Tyrosine Kinase A in the Rat Basal Forebrain by a Novel Antagonistic Anti-Receptor Monoclonal Antibody

  1999cited by this paper
• A TrkA-selective, Fast Internalizing Nerve Growth Factor-Antibody Complex Induces Trophic but Not Neuritogenic Signals*

  1998cited by this paper
• Establishment and characterization of a retinal Müller cell line.

  1998cited by this paper
• Alpha-2 macroglobulin is genetically associated with Alzheimer disease

  1998cited by this paper
• Optimal Nerve Growth Factor Trophic Signals Mediated by Synergy of TrkA and p75 Receptor-Specific Ligands

  1997cited by this paper
• Distribution of NGF receptors in normal and pathologic human lymphoid tissues.

  1997cited by this paper
• Nerve growth factor (NGF) reduces and NGF antibody exacerbates retinal damage induced in rabbit by experimental ocular hypertension

  1997cited by this paper
• Potent human p140-TrkA agonists derived from an anti-receptor monoclonal antibody

  1996cited by this paper
• Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.

  1996cited by this paper
• The cytokine factsbook

  1994cited by this paper
• alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation.

  1994influential reference
• Expression of mRNA encoding neurotrophins and neurotrophin receptors in rat thymus, spleen tissue and immunocompetent cells. Regulation of neurotrophin-4 mRNA expression by mitogens and leukotriene B4.

  1994cited by this paper
• Recombinant mouse tumor necrosis factor expressed in mammalian cells: effect of glycosylation on cytotoxic activity.

  1992cited by this paper

• The Evolution, Oligomerization, Function, and Action Mechanism of α2-Macroglobulin.

  2026cites this paper
• Investigating the Interplay Between the Nrf2/Keap1/HO-1/SIRT-1 Pathway and the p75NTR/PI3K/Akt/MAPK Cascade in Neurological Disorders: Mechanistic Insights and Therapeutic Innovations

  2025cites this paper
• p75NTR antagonist THX-B increases mature nerve growth factor secretion by bladder cells through decreased activity of matrix metalloproteinase-9.

  2025cites this paper
• ProNGF processing in adult rat tissues and bioactivity of NGF prodomain peptides

  2024cites this paper
• Tri-iso-butyl phosphate (TiBP) exposure induces neurotoxicity by triggering oxidative stress accompanied by neurotransmitter system disruptions and apoptosis in zebrafish larvae.

  2024cites this paper
• 3D in vitro modelling of human patient microglia: A focus on clinical translation and drug development in neurodegenerative diseases.

  2023cites this paper
• Alpha-2-macroglobulin prevents platelet aggregation induced by Brain-Derived Neurotrophic Factor.

  2023cites this paper
• Neurotrophins: are they involved in immune tolerance in pregnancy?

  2023cites this paper
• [Pathogenetic role of multifunctional protein alpha-2-macroglobulin and its activity in tears and serum in age-related macular degeneration and proliferative diabetic retinopathy].

  2023cites this paper
• Potential neurotoxic activity of diverse molecules released by astrocytes.

  2022cites this paper
• Tear Biomarkers in Alzheimer’s and Parkinson’s Diseases, and Multiple Sclerosis: Implications for Diagnosis (Systematic Review)

  2022cites this paper
• Impact of NGF signaling on neuroplasticity during depression: Insights in neuroplasticity-dependent therapeutic approaches

  2021cites this paper
• Fabry disease-associated globotriaosylceramide induces mechanical allodynia via activation of signaling through proNGF-p75NTR but not mature NGF-TrkA.

  2021cites this paper
• Proteomic Analysis of Retinal Tissue in an S100B Autoimmune Glaucoma Model

  2021cites this paper
• A Pilot Study of Changes in the Level of Catecholamines and the Activity of α-2-Macroglobulin in the Tear Fluid of Patients with Parkinson’s Disease and Parkinsonian Mice

  2021cites this paper
• Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands

  2020cites this paper
• A Membranome-Centered Approach Defines Novel Biomarkers for Cellular Subtypes in the Intervertebral Disc

  2020cites this paper
• Neurotrophins of the Fetal Brain and Placenta in Prenatal Hyperhomocysteinemia

  2020cites this paper
• Nerve growth factor promotes ASIC1a expression via the NF-κB pathway and enhances acid-induced chondrocyte apoptosis.

  2020cites this paper
• Maternal Hyperhomocysteinemia Induces Neuroinflammation and Neuronal Death in the Rat Offspring Cortex

  2020cites this paper
• Effects of Environmental Enrichment on Neurotrophins in an MPTP-Induced Parkinson’s Disease Animal Model: A Randomized Trial

  2020influential citation
• GALNT6 promotes breast cancer metastasis by increasing mucin-type O-glycosylation of α2M

  2020cites this paper
• Neutralizing antibody to proNGF rescues erectile function by regulating the expression of neurotrophic and angiogenic factors in a mouse model of cavernous nerve injury

  2020cites this paper
• Recent progress in translational engineered in vitro models of the central nervous system

  2020cites this paper
• Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study

  2020cites this paper
• Oral Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Improves Erectile Function in a Mouse Model of Cavernous Nerve Injury.

  2020cites this paper
• Inhibition of proNGF and p75NTR Pathway Restores Erectile Function Through Dual Angiogenic and Neurotrophic Effects in the Diabetic Mouse.

  2019cites this paper
• Alpha-2-Macroglobulin, a Hypochlorite-Regulated Chaperone and Immune System Modulator

  2019cites this paper
• Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration

  2019cites this paper
• Duloxetine protects against experimental diabetic retinopathy in mice through retinal GFAP downregulation and modulation of neurotrophic factors.

  2019cites this paper
• Reconstituting neurovascular unit based on the close relations between neural stem cells and endothelial cells: an effective method to explore neurogenesis and angiogenesis

  2019cites this paper
• Deletion of p75NTR prevents vaso-obliteration and retinal neovascularization via activation of Trk- A receptor in ischemic retinopathy model

  2018cites this paper
• The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy

  2018cites this paper
• A journey into the retina: Müller glia commanding survival and death

  2018cites this paper
• Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa

  2018cites this paper
• Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance

  2018cites this paper
• Identifying stage-specific markers of Alzheimer's disease using quantitative proteomics.

  2018cites this paper
• Variable expression of alpha-2-macroglobulin and tumor necrosis factor-α in the aqueous humor of patients with pseudoexfoliative syndrome with and without glaucoma

  2018cites this paper
• Inducible overexpression of endothelial proNGF as a mouse model to study microvascular dysfunction.

  2018cites this paper
• Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective.

  2018cites this paper
• α2-Macroglobulins: Structure and Function.

  2017cites this paper
• Attenuation of the Infiltration of Angiotensin II Expressing CD3+ T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia – A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT2) Receptor Antagonist

  2017cites this paper
• Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm.

  2017cites this paper
• Decreased serum proNGF concentration in patients with Parkinson’s disease

  2017cites this paper
• N-Propargyl Caffeamide (PACA) Ameliorates Dopaminergic Neuronal Loss and Motor Dysfunctions in MPTP Mouse Model of Parkinson’s Disease and in MPP+-Induced Neurons via Promoting the Conversion of proNGF to NGF

  2017cites this paper
• p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa

  2017cites this paper
• An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation

  2016cites this paper
• Secretomic analysis of extracellular vesicles originating from polyomavirus‐negative and polyomavirus‐positive Merkel cell carcinoma cell lines

  2016cites this paper
• p75NTR and Its Ligand ProNGF Activate Paracrine Mechanisms Etiological to the Vascular, Inflammatory, and Neurodegenerative Pathologies of Diabetic Retinopathy

  2016influential citation
• The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS

  2016cites this paper