Activated NKT Cells Can Condition Different Splenic Dendritic Cell Subsets To Respond More Effectively to TLR Engagement and Enhance Cross-Priming

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Immunology

• Publication date

  2015-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1401751PMID 26078270
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian α-linked glycosylceramides.

  2014cited by this paper
• Batf3‐independent langerin− CX3CR1− CD8α+ splenic DCs represent a precursor for classical cross‐presenting CD8α+ DCs

  2014cited by this paper
• Sustained in vivo depletion of splenic langerin(+) CD8α(+) dendritic cells is well-tolerated by lang-DTREGFP mice.

  2014cited by this paper
• Invariant NKT Cells Induce Plasmacytoid Dendritic Cell (DC) Cross-Talk with Conventional DCs for Efficient Memory CD8+ T Cell Induction

  2013cited by this paper
• Toll-like Receptor agonists and alpha-galactosylceramide synergistically enhance the production of interferon-gamma in murine splenocytes

  2013cited by this paper
• The Mechanism of Splenic Invariant NKT Cell Activation Dictates Localization In Vivo

  2013cited by this paper
• Type I Interferons as Stimulators of DC-Mediated Cross-Priming: Impact on Anti-Tumor Response

  2013cited by this paper
• DEC-205 is a cell surface receptor for CpG oligonucleotides

  2013cited by this paper
• Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota

  2013cited by this paper
• Targeting dendritic cells--why bother?

  2013cited by this paper
• DEC-205 is a cell surface receptor for CpG oligonucleotides

  2012cited by this paper
• Harnessing human plasmacytoid dendritic cells as professional APCs

  2012cited by this paper
• MR1 presents microbial vitamin B metabolites to MAIT cells

  2012cited by this paper
• Cutting Edge: Clec9A+ Dendritic Cells Mediate the Development of Experimental Cerebral Malaria

  2012cited by this paper
• Serine Protease Inhibitor 6 Is Required To Protect Dendritic Cells from the Kiss of Death

  2012cited by this paper
• The location of splenic NKT cells favours their rapid activation by blood-borne antigen

  2012cited by this paper
• Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A

  2011cited by this paper
• Invariant NKT cells recognize glycolipids from pathogenic Gram-positive bacteria

  2011cited by this paper
• Administration of α‐galactosylceramide impairs the survival of dendritic cell subpopulations in vivo

  2011cited by this paper
• Murine Melanoma-Infiltrating Dendritic Cells Are Defective in Antigen Presenting Function Regardless of the Presence of CD4+CD25+ Regulatory T Cells

  2011cited by this paper
• Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype

  2011cited by this paper
• TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway.

  2011cited by this paper
• CX3CR1+ CD8α+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells

  2010cited by this paper
• Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenza

  2010cited by this paper
• Antibody to Langerin/CD207 localizes large numbers of CD8α+ dendritic cells to the marginal zone of mouse spleen

  2009cited by this paper
• NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner.

  2009cited by this paper
• Novel Subset of CD8α+ Dendritic Cells Localized in the Marginal Zone Is Responsible for Tolerance to Cell-Associated Antigens1

  2009cited by this paper
• Langerin+CD8α+ Dendritic Cells Are Critical for Cross-Priming and IL-12 Production in Response to Systemic Antigens1

  2009cited by this paper
• Cutting Edge: Langerin/CD207 Receptor on Dendritic Cells Mediates Efficient Antigen Presentation on MHC I and II Products In Vivo1

  2008cited by this paper
• Dendritic Cell Function Can Be Modulated through Cooperative Actions of TLR Ligands and Invariant NKT Cells1

  2007cited by this paper
• Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation.

  2007cited by this paper
• Differential Antigen Processing by Dendritic Cell Subsets in Vivo

  2007cited by this paper
• TLR ligands differentially affect uptake and presentation of cellular antigens.

  2007cited by this paper
• Distinct Uptake Mechanisms but Similar Intracellular Processing of Two Different Toll-like Receptor Ligand-Peptide Conjugates in Dendritic Cells*

  2007cited by this paper
• Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-α/β on antigen cross-presentation

  2007cited by this paper
• The delivery of an antigen from the endocytic compartment into the cytosol for cross‐presentation is restricted to early immature dendritic cells

  2006cited by this paper
• Novel synthesis of alpha-galactosyl-ceramides and confirmation of their powerful NKT cell agonist activity.

  2006cited by this paper
• Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors.

  2006cited by this paper
• Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity

  2006cited by this paper
• Type I interferon dependence of plasmacytoid dendritic cell activation and migration

  2005influential reference
• Efficient Synthesis of α-Galactosyl Ceramide Analogues Using Glycosyl Iodide Donors

  2005cited by this paper
• Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

  2005cited by this paper
• Recognition of bacterial glycosphingolipids by natural killer T cells

  2005cited by this paper
• Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections

  2005cited by this paper
• Structure and function of the spleen

  2005influential reference
• Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells.

  2005cited by this paper
• Efficient synthesis of alpha-galactosyl ceramide analogues using glycosyl iodide donors.

  2005cited by this paper
• Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells.

  2005cited by this paper
• Toll-like receptor control of the adaptive immune responses

  2004cited by this paper
• Activation of Natural Killer T Cells by -Galactosylceramide Rapidly Induces the Full Maturation of Dendritic Cells In Vivo and Thereby Acts as an Adjuvant for Combined CD4 and CD8 T Cell Immunity to a Coadministered Protein

  2003cited by this paper
• Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α+ DC correlates with unresponsiveness to imidazoquinolines

  2003influential reference
• NKT Cells Enhance CD4+ and CD8+ T Cell Responses to Soluble Antigen In Vivo through Direct Interaction with Dendritic Cells 1

  2003cited by this paper
• Cross‐presentation of cell‐associated antigens by CD8α+ dendritic cells is attributable to their ability to internalize dead cells

  2002cited by this paper
• The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo

  2002cited by this paper
• A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors.

  2002cited by this paper
• Expression of the Serpin Serine Protease Inhibitor 6 Protects Dendritic Cells from Cytotoxic T Lymphocyte–Induced Apoptosis

  2001cited by this paper
• IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation1

  2001cited by this paper
• The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes.

  2000cited by this paper
• Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma.

  2000cited by this paper
• Characterization of the ovalbumin‐specific TCR transgenic line OT‐I: MHC elements for positive and negative selection

  2000influential reference
• Stimulation of γδ T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma

  2000cited by this paper
• Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

  2000cited by this paper
• The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells

  1999cited by this paper
• Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells.

  1999cited by this paper
• Survival Surgery: Removal of the Spleen or Thymus

  1992cited by this paper
• Introduction of soluble protein into the class I pathway of antigen processing and presentation.

  1988cited by this paper

• Intraperitoneal administration of cationic liposomes containing a TLR3 agonist recruits type I conventional dendritic cells and primes a local CD8+ T cell response.

  2025cites this paper
• Enhancing COVID-19 Vaccine Efficacy: Dual Adjuvant Strategies with TLR7/8 Agonists and Glycolipids.

  2024cites this paper
• iNKT cell agonists as vaccine adjuvants to combat infectious diseases.

  2022cites this paper
• New insights into iNKT cells and their roles in liver diseases

  2022cites this paper
• Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effect

  2022cites this paper
• Intranasal Therapeutic Peptide Vaccine Promotes Efficient Induction and Trafficking of Cytotoxic T Cell Response for the Clearance of HPV Vaginal Tumors

  2020cites this paper
• Modulating the Tumour Microenvironment by Intratumoural Injection of Pattern Recognition Receptor Agonists

  2020cites this paper
• Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

  2020cites this paper
• Langerin+CD8+ Dendritic Cells in the Splenic Marginal Zone: Not So Marginal After All

  2019cites this paper
• Development of TCR-engineered iNKT cells for Cancer Immunotherapy

  2018cites this paper
• Langerin+ CD8α+ Dendritic Cells Drive Early CD8+ T Cell Activation and IL-12 Production During Systemic Bacterial Infection

  2018cites this paper
• Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis

  2018cites this paper
• The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator?

  2018cites this paper
• Vaccine Designs Utilizing Invariant NKT-Licensed Antigen-Presenting Cells Provide NKT or T Cell Help for B Cell Responses

  2018cites this paper
• Blockade of only TGF-β 1 and 2 is sufficient to enhance the efficacy of vaccine and PD-1 checkpoint blockade immunotherapy

  2017cites this paper
• Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

  2017cites this paper
• Engaging Natural Killer T Cells as ‘Universal Helpers’ for Vaccination

  2016cites this paper