Differentiation of genetic versus epigenetic mechanisms of toxicity and its application to risk assessment.

No abstract is available for this paper.

• Publication year

  1982

• Venue

  Drug metabolism reviews (Softcover ed.)

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.3109/03602538208991365PMID 6754312
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  year unknowncited by this paper

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