A novel limonin derivate modulates inflammatory response by suppressing the TLR4/NF-κB signalling pathway.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

• Publication date

  2018-02-23

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.biopha.2018.02.046PMID 29477914
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• LFG-500, a newly synthesized flavonoid, attenuates lipopolysaccharide-induced acute lung injury and inflammation in mice.

  2016cited by this paper
• Inhibitory Effects of Isorhamnetin on the Invasion of Human Breast Carcinoma Cells by Downregulating the Expression and Activity of Matrix Metalloproteinase-2/9

  2015cited by this paper
• Endotoxemia Induces IκBβ/NF-κB–Dependent Endothelin-1 Expression in Hepatic Macrophages

  2015cited by this paper
• The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation.

  2014cited by this paper
• Regulation of microRNA‐155 in Endothelial Inflammation by Targeting Nuclear Factor (NF)‐κB P65

  2014cited by this paper
• Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications.

  2014cited by this paper
• Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation

  2014cited by this paper
• Synthesis and pharmacological evaluation of novel limonin derivatives as anti-inflammatory and analgesic agents with high water solubility.

  2014cited by this paper
• Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy.

  2013cited by this paper
• Anti-inflammatory properties of a dual PPARgamma/alpha agonist muraglitazar in in vitro and in vivo models

  2013cited by this paper
• MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways

  2013cited by this paper
• NF‐κB and the link between inflammation and cancer

  2012cited by this paper
• Inflammation in Atherosclerosis

  2012cited by this paper
• Echinocystic acid ameliorates lung inflammation in mice and alveolar macrophages by inhibiting the binding of LPS to TLR4 in NF-κB and MAPK pathways.

  2012cited by this paper
• Kaempferol and Kaempferol Rhamnosides with Depigmenting and Anti-Inflammatory Properties

  2011cited by this paper
• Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK‐1 activation in the NF‐κB and MAPK pathways

  2011cited by this paper
• miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice

  2011cited by this paper
• MiR‐146a inhibits oxidized low‐density lipoprotein‐induced lipid accumulation and inflammatory response via targeting toll‐like receptor 4

  2011cited by this paper
• Striking inflammation from both sides: manganese(II) pentaazamacrocyclic SOD mimics act also as nitric oxide dismutases: a single-cell study.

  2010cited by this paper
• Vinpocetine inhibits NF-κB–dependent inflammation via an IKK-dependent but PDE-independent mechanism

  2010cited by this paper
• Inhibiting NF-κB activation by small molecules as a therapeutic strategy.

  2010cited by this paper
• A sensitive liquid chromatography-electrospray tandem mass spectrometric method for lancemaside A and its metabolites in plasma and a pharmacokinetic study in mice.

  2010cited by this paper
• Tumor necrosis factor-α signaling in macrophages.

  2010cited by this paper
• Inhibition of transcription factors by plant-derived compounds and their implications in inflammation and cancer.

  2009cited by this paper
• MicroRNAs: Target Recognition and Regulatory Functions

  2009cited by this paper
• META060 inhibits multiple kinases in the NF-κB pathway and suppresses LPS – mediated inflammation in vitro and ex vivo

  2009cited by this paper
• Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the L-arginine/nitric oxide area of research.

  2007cited by this paper
• NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

  2006cited by this paper
• Limonoids: overview of significant bioactive triterpenes distributed in plants kingdom.

  2006cited by this paper
• COX-2 in inflammation and resolution.

  2006cited by this paper
• Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid.

  2006cited by this paper
• Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid

  2006cited by this paper
• Nitric oxide production and signaling in inflammation.

  2005cited by this paper
• Nitric Oxide, a Mediator of Inflammation, Suppresses Tumorigenesis

  2004cited by this paper
• Inflammation in atherosclerosis

  2002cited by this paper
• NF-?B regulation in the immune system

  2002cited by this paper
• NF-kappaB regulation in the immune system.

  2002cited by this paper
• The role of nitric oxide in tissue destruction.

  2001cited by this paper
• Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats.

  2000cited by this paper
• Activation of the transcription factor NF-κB in the rat air pouch model of inflammation

  2000cited by this paper
• Activation of the transcription factor NF-kappaB in the rat air pouch model of inflammation.

  2000cited by this paper

• Beyond bitterness: a comprehensive review of limonoid debittering, bioavailability, metabolic regulation, and potential biological significance of bitterness

  2026cites this paper
• Role of ILC2s as Potential Effector Cells of IL25-Mediated Type 2 Inflammation in Chronic Rhinosinusitis with Nasal Polyps in China

  2025cites this paper
• Bibliometric and visual analysis of immunisation associated with acute kidney injury from 2003 to 2023

  2024cites this paper
• Limonin (LM) and its derivatives: Unveiling the neuroprotective and anti-inflammatory potential of LM and V-A-4 in the management of Alzheimer's disease and Parkinson's disease.

  2024cites this paper
• Effect of quercetin on acute appendicitis by reduction of Caspase-1 and inflammatory factors release through Toll-like receptor 4/nuclear factor kappa-B pathway

  2023cites this paper
• An overview of limonoid synthetic derivatives as promising bioactive molecules.

  2023cites this paper
• Limonin ameliorates indomethacin‐induced intestinal damage and ulcers through Nrf2/ARE pathway

  2023cites this paper
• Preclinical Drug Pharmacokinetic, Tissue Distribution and Excretion Profiles of the Novel Limonin Derivate HY-071085 as an Anti-Inflammatory and Analgesic Candidate in Rats and Beagle Dogs

  2022cites this paper
• Diverse Galactooligosaccharides Differentially Reduce LPS-Induced Inflammation in Macrophages

  2022cites this paper
• Limonoids from the bark of Toona ciliata var pubescens and their anti-tumor activities

  2022cites this paper
• Bioactivity‐guided isolation of anti‐inflammatory limonins from Chukrasia tabularis

  2022cites this paper
• Identification of candidate genes and pathways in limonin-mediated cardiac repair after myocardial infarction.

  2021cites this paper
• New limonoids and quinolone alkaloids with cytotoxic and anti-platelet aggregation activities from Evodia rutaecarpa (Juss.) Benth.

  2021cites this paper
• Limonin ameliorates acute pancreatitis by suppressing JAK2/STAT3 signaling pathway

  2021cites this paper
• Design, Synthesis, and In Vitro and In Vivo Biological Evaluation of Limonin Derivatives for Anti-Inflammation Therapy.

  2021cites this paper
• The In Vitro Anti-Inflammatory Activities of Galangin and Quercetin towards the LPS-Injured Rat Intestinal Epithelial (IEC-6) Cells as Affected by Heat Treatment

  2021cites this paper
• Synthesis of Limonin Derivatives with Improved Anti-inflammatory and Analgesic Properties

  2020cites this paper
• Lactoferrin suppresses LPS-induced expression of HMGB1, microRNA 155, 146, and TLR4/MyD88/NF-кB pathway in RAW264.7 cells

  2020cites this paper
• Limonin ameliorates dextran sulfate sodium-induced chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-κB signaling.

  2020cites this paper
• A practical synthesis of amino limonin/deoxylimonin derivatives as effective mitigators against inflammation and nociception.

  2020cites this paper
• Chemical Constituents from Citrus changshan‐huyou and Their Anti‐Inflammatory Activities

  2020cites this paper
• Discovery of deoxylimonin δ-lactam derivative with favorable anti-inflammation and antinociception efficacy from chemical modified limonin/deoxylimonin analogs.

  2020cites this paper
• The Protective Effect of rhBNP on Postresuscitation Myocardial Dysfunction in a Rat Cardiac Arrest Model

  2020cites this paper
• Novel nortriterpenoids with new skeletons and limonoids from the fruits of Evodia rutaecarpa and their bioactivities.

  2020cites this paper
• Limonin: A Review of Its Pharmacology, Toxicity, and Pharmacokinetics

  2019cites this paper
• Limonin enhances the radiosensitivity of nasopharyngeal carcinoma cells via attenuating Stat3-induced cell stemness.

  2019cites this paper
• Analysis of Evodiae Fructus by capillary electrochromatography-mass spectrometry with methyl-vinylimidazole functionalized organic polymer monolilth as stationary phases.

  2019cites this paper