The Differential Effects of pp120 (Ceacam 1) on the Mitogenic Action of Insulin and Insulin-Like Growth Factor 1 Are Regulated by the Nonconserved Tyrosine 1316 in the Insulin Receptor

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Molecular and Cellular Biology

• Publication date

  2000-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.20.11.3896-3905.2000PMID 10805733PMCID PMC85733
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Redefined nomenclature for members of the carcinoembryonic antigen family.

  1999cited by this paper
• The Carboxyl-terminal Region of Biliary Glycoprotein Controls Its Tyrosine Phosphorylation and Association with Protein-tyrosine Phosphatases SHP-1 and SHP-2 in Epithelial Cells*

  1999cited by this paper
• Persistent expression of foreign genes in cultured hepatocytes: expression vectors.

  1999cited by this paper
• pp120, a substrate of the insulin receptor tyrosine kinase, is associated with phosphatase activity.

  1998cited by this paper
• Disruption of IRS-2 causes type 2 diabetes in mice

  1998cited by this paper
• Effect of pp120 on Receptor-mediated Insulin Endocytosis Is Regulated by the Juxtamembrane Domain of the Insulin Receptor*

  1998cited by this paper
• The IRS-signalling system: A network of docking proteins that mediate insulin action

  1998cited by this paper
• Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes*

  1998influential reference
• Association of an 80  kDa protein with C-CAM1 cytoplasmic domain correlates with C-CAM1-mediated growth inhibition

  1998cited by this paper
• Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors.

  1997influential reference
• Suppression of tumorigenicity of breast cancer cells by an epithelial cell adhesion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains

  1997cited by this paper
• Tyrosine residues in the C-terminal domain of the insulin-like growth factor-I receptor mediate mitogenic and tumorigenic signals.

  1997influential reference
• Proliferation of adult rat hepatocytes in primary culture induced by insulin is potentiated by cAMP-elevating agents.

  1997cited by this paper
• Differential phosphorylation of pp120 by insulin and insulin-like growth factor-1 receptors: role for the C-terminal domain of the beta-subunit.

  1997cited by this paper
• Optimal ratios of biliary glycoprotein isoforms required for inhibition of colonic tumor cell growth.

  1997cited by this paper
• Suppression of human bladder cancer growth by increased expression of C-CAM1 gene in an orthotopic model.

  1996cited by this paper
• Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

  1996influential reference
• Effect of Mutations at Serines 1280–1283 on the Mitogenic and Transforming Activities of the Insulin-like Growth Factor I Receptor (*)

  1996cited by this paper
• Tumor suppressive role of an androgen-regulated epithelial cell adhesion molecule (C-CAM) in prostate carcinoma cell revealed by sense and antisense approaches.

  1995cited by this paper
• Activation of protein kinase C alpha inhibits signaling by members of the insulin receptor family.

  1995cited by this paper
• Receptor-mediated Internalization of Insulin

  1995cited by this paper
• Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase.

  1995cited by this paper
• Insulin inhibits nuclear phosphatase activity: requirement for the C-terminal domain of the insulin receptor.

  1995cited by this paper
• Consistent expression of an epithelial cell adhesion molecule (C-CAM) during human prostate development and loss of expression in prostate cancer: implication as a tumor suppressor.

  1995cited by this paper
• Non-SH2 Domains within Insulin Receptor Substrate-1 and SHC Mediate Their Phosphotyrosine-dependent Interaction with the NPEY Motif of the Insulin-like Growth Factor I Receptor (*)

  1995cited by this paper
• Activation of Protein Kinase Cα Inhibits Signaling by Members of the Insulin Receptor Family (*)

  1995cited by this paper
• Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

  1995cited by this paper
• Bile acid efflux mediated by the rat liver canalicular bile acid transport/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation.

  1994cited by this paper
• Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP.

  1994cited by this paper
• Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction.

  1994cited by this paper
• Signal transduction by a chimeric insulin-like growth factor-1 (IGF-1) receptor having the carboxyl-terminal domain of the insulin receptor.

  1994cited by this paper
• Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor.

  1994cited by this paper
• Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor.

  1994cited by this paper
• Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

  1994cited by this paper
• The insulin receptor: structure, function, and signaling.

  1994cited by this paper
• Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

  1994cited by this paper
• Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function.

  1994influential reference
• Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses

  1994influential reference
• Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.

  1994cited by this paper
• Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action.

  1994cited by this paper
• Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

  1994cited by this paper
• The insulin signaling system.

  1994cited by this paper
• Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase.

  1994cited by this paper
• Cell CAM 105 isoform RNA expression is differentially regulated during rat liver regeneration and carcinogenesis.

  1994cited by this paper
• Cell-CAM105 isoforms with different adhesion functions are coexpressed in adult rat tissues and during liver development.

  1993cited by this paper
• Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

  1993cited by this paper
• pp120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms.

  1993cited by this paper
• The function of GRB2 in linking the insulin receptor to Ras signaling pathways.

  1993influential reference
• Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor.

  1993cited by this paper
• Extracellular signals and reversible protein phosphorylation: what to Mek of it all.

  1993cited by this paper
• Role of insulin-like growth factors in embryonic and postnatal growth.

  1993cited by this paper
• Signal transduction via the MAP kinases: proceed at your own RSK.

  1993cited by this paper
• Evidence for calmodulin binding to the cytoplasmic domains of two C‐CAM isoforms

  1993cited by this paper
• Normal insulin receptor substrate-1 phosphorylation in autophosphorylation-defective truncated insulin receptor. Evidence that phosphorylation of substrates might be sufficient for certain biological effects evoked by insulin.

  1993cited by this paper
• The expression of mouse biliary glycoprotein, a carcinoembryonic antigen-related gene, is down-regulated in malignant mouse tissues.

  1993cited by this paper
• Structure-function relationship of the insulin-like growth factor-I receptor tyrosine kinase.

  1993cited by this paper
• Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas.

  1993cited by this paper
• Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).

  1993influential reference
• Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.

  1993cited by this paper
• Human insulin-like growth factor I receptor 950tyrosine is required for somatotroph growth factor signal transduction.

  1992cited by this paper
• The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.

  1992influential reference
• Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.

  1992cited by this paper
• The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities.

  1992cited by this paper
• Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophosphorylation sites by phenylalanine.

  1992cited by this paper
• Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites.

  1992cited by this paper
• Tissue-specific expression of the rat insulin receptor-related receptor gene.

  1992cited by this paper
• Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties.

  1991influential reference
• Multisite serine phosphorylation of the insulin and IGF‐I receptors in transfected cells

  1991cited by this paper
• The role of insulin receptor autophosphorylation in signal transduction.

  1991influential reference
• Hepatocyte plasma membrane ECTO-ATPase (pp120/HA4) is a substrate for tyrosine kinase activity of the insulin receptor.

  1990cited by this paper
• Cloning and expression of a cDNA coding for a rat liver plasma membrane ecto-ATPase. The primary structure of the ecto-ATPase is similar to that of the human biliary glycoprotein I.

  1989cited by this paper
• Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects.

  1988cited by this paper
• Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity.

  1988cited by this paper
• Purification and characterization of the receptor for insulin-like growth factor I.

  1986cited by this paper
• Alterations in the expression of a hepatocyte cell adhesion molecule by transplantable rat hepatocellular carcinomas.

  1985cited by this paper

• Regulation and function of insulin and insulin-like growth factor receptor signalling

  2025cites this paper
• Insulin increases type I collagen synthesis in hepatic stellate cells via α5β1 integrin

  2024cites this paper
• Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1

  2021cites this paper
• Comprehensive insulin receptor phosphorylation dynamics profiled by mass spectrometry

  2021cites this paper
• Hepatic Insulin Clearance: Mechanism and Physiology.

  2019cites this paper
• Size Matters: The Functional Role of the CEACAM1 Isoform Signature and Its Impact for NK Cell-Mediated Killing in Melanoma

  2019cites this paper
• CEACAM1 in Liver Injury, Metabolic and Immune Regulation

  2018cites this paper
• A Role for CEACAM2 protein in Insulin Secretion, Clearance and Action

  2017cites this paper
• CEACAM1 is overexpressed in oral tumors and related to tumorigenesis

  2017cites this paper
• Carcinoembryonic antigen-related cell adhesion molecule 1 is expressed and as a function histotype in ovarian tumors.

  2016cites this paper
• Nicotinamide Mononucleotide in the Context of Elevated Plasma Levels of Free Fatty Acids Improves Glucose Tolerance by Decreasing Insulin Clearance

  2016cites this paper
• Effects of Cardiotonic Steroids and Insulin on Sodium Pump Signaling

  2014cites this paper
• Demonstration of a Direct Interaction between β2-Adrenergic Receptor and Insulin Receptor by BRET and Bioinformatics

  2014cites this paper
• Overlaps Between the Insulin and IGF-I Receptor and Cancer

  2012cites this paper
• Extracellular IgC2 Constant Domains of CEACAMs Mediate PI3K Sensitivity during Uptake of Pathogens

  2012cites this paper
• Internalization of pathogens in mammalian cells via CEACAM1

  2012cites this paper
• Examination of molecular changes in acquired tamoxifen resistance and subsequent response to anti-IGF1R therapy.

  2012cites this paper
• The Insulin Receptor: A New Target for Cancer Therapy

  2011cites this paper
• Mechanisms underlying the link between obesity and neoplastic progression.

  2010cites this paper
• A role for CEACAM2 in insulin homeostasis and action

  2010cites this paper
• Sequencing of type I insulin-like growth factor receptor inhibition with chemotherapy in breast cancer cells.

  2009cites this paper
• Altered splicing of CEACAM1 in breast cancer: Identification of regulatory sequences that control splicing of CEACAM1 into long or short cytoplasmic domain isoforms

  2008cites this paper
• The role of insulin receptors and IGF-I receptors in cancer and other diseases

  2008cites this paper
• Reduction of Hepatic CEACAM1 Levels: an Early Mechanism of Insulin Resistance Induced by High-Fat Diet

  2008influential citation
• CEACAM1: A Common Regulator of Fat Metabolism and Cell Proliferation

  2008influential citation
• INIBIZIONE DI IGF1R: ANALISI COMPARATIVA DEL RUOLO TERAPEUTICO DELL'INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR NEL SARCOMA DI EWING

  2007cites this paper
• The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer.

  2007cites this paper
• La régulation du métabolisme du glucose par la protéine tyrosine phosphatase SHP-1

  2007cites this paper
• From the Department of Oncology and Pathology, Division of Cellular and Molecular Tumor Pathology, Cancer Center Karolinska Karolinska Institutet, Stockholm, Sweden IGF-1R INHIBITION: A TOOL FOR FUNCTIONAL STUDIES OF INSULIN- LIKE GROWTH FACTORS FAMILY IN MALIGNANT CELLS

  2006cites this paper
• Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1.

  2006cites this paper
• IGF-1R inhibition : A tool for functional studies of insulin-like growth factor family in malignant cells

  2006cites this paper
• dominant negative mutation of CEACAM1 Mechanism of glucose intolerance in mice with

  2006cites this paper
• CEACAM1 links metabolism to epidermal growth factor receptor-dependent cell proliferation.

  2005influential citation
• CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation.

  2004cites this paper
• CEACAM1 modulates epidermal growth factor receptor–mediated cell proliferation

  2004cites this paper
• Insulin and Insulin-Like Growth Factor I Receptors: Similarities and Differences in Signal Transduction

  2004cites this paper
• CEACAM1 : a molecular link between fat metabolism and insulin clearance

  2004cites this paper
• Differential role of CEACAM1 and CEACAM2 in insulin metabolism

  2004cites this paper
• CEA-Related CAMs.

  2004cites this paper
• The Insulin-Like Growth Factor System

  2003influential citation
• Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression.

  2003influential citation
• IGF-1 induces growth, survival and morphological change of primary hepatocytes on a galactose-bared polymer through both MAPK and beta-catenin pathways.

  2003cites this paper
• Signalling through IGF-I and insulin receptors: where is the specificity?

  2002cites this paper
• Hormone Signaling

  2002cites this paper
• CEACAM1 regulates insulin clearance in liver

  2002cites this paper
• Regulation of insulin action by CEACAM1.

  2002cites this paper
• Shc and CEACAM1 Interact to Regulate the Mitogenic Action of Insulin*

  2002cites this paper
• Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors.

  2001cites this paper
• Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice

  2001cites this paper
• Microarray Analysis and Identification of Novel Molecules Involved in Insulin-like Growth Factor-1 Receptor Signaling and Gene Expression

  year unknowncites this paper