Cytosolic and Secreted Peptidoglycan-Degrading Enzymes in Drosophila Respectively Control Local and Systemic Immune Responses to Microbiota.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Cell Host and Microbe

• Publication date

  2018-02-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.chom.2017.12.007PMID 29398649
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of a NF-κB/Diap1 Pathway by PGRP-LF Is Required for Proper Apoptosis during Drosophila Development

  2017cited by this paper
• Host-Microbiota Interactions Shape Local and Systemic Inflammatory Diseases

  2017cited by this paper
• Peptidoglycan sensing by octopaminergic neurons modulates Drosophila oviposition

  2017cited by this paper
• The microbiota in adaptive immune homeostasis and disease

  2016cited by this paper
• Muscles provide protection during microbial infection by activating innate immune response pathways in Drosophila and zebrafish

  2016cited by this paper
• The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors

  2016cited by this paper
• Gut microbiota, metabolites and host immunity

  2016cited by this paper
• The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior

  2016cited by this paper
• The Central Nervous System and the Gut Microbiome.

  2016cited by this paper
• Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes.

  2015cited by this paper
• CoinFLP: a system for efficient mosaic screening and for visualizing clonal boundaries in Drosophila

  2015cited by this paper
• All for one and one for all: Regionalization of the Drosophila intestine.

  2015cited by this paper
• Studying host-microbiota mutualism in Drosophila: Harnessing the power of gnotobiotic flies

  2015cited by this paper
• CYLD negatively regulates Hippo signaling by limiting Hpo phosphorylation in Drosophila.

  2014cited by this paper
• PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan.

  2014cited by this paper
• Morphological and molecular characterization of adult midgut compartmentalization in Drosophila.

  2013cited by this paper
• Host-intestinal microbiota mutualism: "learning on the fly".

  2013cited by this paper
• NOD proteins: regulators of inflammation in health and disease

  2013cited by this paper
• Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in Drosophila.

  2013cited by this paper
• Gut homeostasis in a microbial world: insights from Drosophila melanogaster

  2013cited by this paper
• The gut microbiota — masters of host development and physiology

  2013cited by this paper
• Tissue- and Ligand-Specific Sensing of Gram-Negative Infection in Drosophila by PGRP-LC Isoforms and PGRP-LE

  2012cited by this paper
• Peptidoglycan sensing by the receptor PGRP-LE in the Drosophila gut induces immune responses to infectious bacteria and tolerance to microbiota.

  2012cited by this paper
• PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse’s offspring

  2012cited by this paper
• Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila

  2012cited by this paper
• Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection.

  2011cited by this paper
• Negative regulation of immune responses on the fly

  2011cited by this paper
• Drosophila Immunity: Analysis of PGRP-SB1 Expression, Enzymatic Activity and Function

  2011cited by this paper
• Extracellular and intracellular pathogen recognition by Drosophila PGRP-LE and PGRP-LC.

  2010cited by this paper
• Recognition of Peptidoglycan from the Microbiota by Nod1 Enhances Systemic Innate Immunity

  2010cited by this paper
• Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission

  2009cited by this paper
• Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune response

  2009cited by this paper
• Autophagic control of listeria through intracellular innate immune recognition in drosophila

  2008cited by this paper
• Innate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila

  2008cited by this paper
• Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

  2008cited by this paper
• Host PGRP Gene Expression and Bacterial Release in Endosymbiosis of the Weevil Sitophilus zeamais

  2006cited by this paper
• The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection.

  2006cited by this paper
• PGRP-SB1: an N-acetylmuramoyl L-alanine amidase with antibacterial activity.

  2006cited by this paper
• PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan

  2006cited by this paper
• Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species.

  2005cited by this paper
• Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor.

  2005cited by this paper
• Peptidoglycan recognition protein (PGRP)‐LE and PGRP‐LC act synergistically in Drosophila immunity

  2004cited by this paper
• A Scavenger Function for a DrosophilaPeptidoglycan Recognition Protein*

  2003cited by this paper
• The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

  2002cited by this paper
• Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli

  2002cited by this paper
• The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response.

  2000cited by this paper

• Application of Proteins Binding Components of Bacterial Cell Wall for Extraction, Concentration, and Analysis of Biological Samples

  2026cites this paper
• Bacteriocyte-specific antimicrobial peptides regulate the Rhynchophorus ferrugineus-Nardonella symbiosis and represent novel targets for symbiosis-based pest control.

  2026cites this paper
• A PGRPLC1/Rel2-F axis controls Anopheles gambiae resistance to systemic infections with Gram-positive bacteria containing Lys-type peptidoglycan

  2025cites this paper
• Cell wall components of gut commensal bacteria stimulate peritrophic matrix formation in malaria vector mosquitoes through activation of the IMD pathway

  2025cites this paper
• Expression and functional characterization of three peptidoglycan recognition proteins, PGRP-L1, PGRP-L2 and PGRP-S in snakehead (Channa argus)

  2025cites this paper
• Peptidoglycan recognition protein L1 regulates intestinal immunity and microbial homeostasis  via the IMD pathway in the silkworm, Bombyx mori.

  2025cites this paper
• The Role of AaPGRP-LB in the Immune Response of Aedes albopictus Against Bacteria Infection

  2025cites this paper
• Bacterial-tyramine-induced renal-gut countercurrent flow regulates gut immune response by promoting ROS accumulation and gut peristalsis in the fly Bactrocera dorsalis

  2024cites this paper
• The role of animal hosts in shaping gut microbiome variation

  2024cites this paper
• A CTL − Lys immune function maintains insect metamorphosis by preventing gut bacterial dysbiosis and limiting opportunistic infections

  2024cites this paper
• Fulvic acid modulates mucosal immunity in fish skin: Sustainable aquaculture solution or environmental risk factor?

  2024cites this paper
• MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in Drosophila gut during inflammation

  2024cites this paper
• Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae

  2024cites this paper
• Black Soldier Fly Larvae Promote the Resource of Cyanobacteria: Frass-Mixed Compost

  2024cites this paper
• Ingestion of Bacillus cereus spores dampens the immune response to favor bacterial persistence

  2024influential citation
• MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in the Drosophila gut during inflammation

  2024cites this paper
• Bacterial peptidoglycan serves as a critical modulator of the gut-immune-brain axis in Drosophila.

  2024influential citation
• High-fat diets induce inflammatory IMD/NFκB signaling via gut microbiota remodeling in Drosophila

  2024cites this paper
• The conceptual foundations of innate immunity: Taking stock 30 years later.

  2024cites this paper
• PcEiger links the Imd/Relish pathway to ROS production in the intestine of the red swamp crayfish

  2023cites this paper
• Short peptidoglycan recognition protein 5 modulates immune response to bacteria in Indian major carp, Cirrhinusmrigala.

  2023cites this paper
• Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow

  2023cites this paper
• Cereal Weevil’s Antimicrobial Peptides: At the Crosstalk between Development, Endosymbiosis and Immune Response

  2023cites this paper
• Role of Rab5 early endosomes in regulating Drosophila gut antibacterial response

  2023cites this paper
• Role of Rab5 early endosomes in regulating Drosophila gut antibacterial response

  2023cites this paper
• Steroid hormone regulation of innate immunity in Drosophila melanogaster

  2023cites this paper
• Immunogenic molecules associated with gut bacterial cell walls: chemical structures, immune-modulating functions, and mechanisms

  2023influential citation
• Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in Drosophila

  2023cites this paper
• Ingestion of Bacillus cereus spores dampens the immune response to favor bacterial persistence

  2023cites this paper
• Main Components of Fish Immunity: An Overview of the Fish Immune System

  2023cites this paper
• Investigating local and systemic intestinal signalling in health and disease with Drosophila

  2022cites this paper
• Peptidoglycan recognition protein SC (PGRP‐SC) shapes gut microbiota richness, diversity and composition by modulating immunity in the house fly Musca domestica

  2022influential citation
• Drosophila melanogaster as a model to study innate immune memory

  2022cites this paper
• Compartmentalized PGRP expression along the dipteran Bactrocera dorsalis gut forms a zone of protection for symbiotic bacteria.

  2022cites this paper
• Dynamic Regulation of NF-κB Response in Innate Immunity: The Case of the IMD Pathway in Drosophila

  2022influential citation
• Bacteria-Derived Peptidoglycan Triggers a Noncanonical Nuclear Factor-κB-Dependent Response in Drosophila Gustatory Neurons

  2022cites this paper
• Renal NF-κB activation impairs uric acid homeostasis to promote tumor-associated mortality independent of wasting.

  2022cites this paper
• Peptidoglycan recognition proteins from the earthworm, Eisenia andrei: Differential inducibility and tissue-specific expression.

  2022cites this paper
• Enteric bacterial infection in Drosophila induces whole-body alterations in metabolic gene expression independently of the immune deficiency signaling pathway

  2022cites this paper
• Dual mode of PGRP-LE-dependent NF-  B pathway activation in bacteria infected

  2022cites this paper
• Gut-derived peptidoglycan remotely inhibits bacteria dependent activation of SREBP by Drosophila adipocytes

  2022cites this paper
• Midgut and Head Transcriptomic Analysis of Silkworms Reveals the Physiological Effects of Artificial Diets

  2022cites this paper
• Sensing microbial infections in the Drosophila melanogaster genetic model organism

  2022influential citation
• The Negative Regulative Roles of BdPGRPs in the Imd Signaling Pathway of Bactrocera dorsalis

  2022cites this paper
• Characterization of PGRP-LB and immune deficiency in the white-backed planthopper Sogatella furcifera (Hemiptera: Delphacidae)

  2021cites this paper
• Drosophila Antimicrobial Peptides and Lysozymes Regulate Gut Microbiota Composition and Abundance

  2021cites this paper
• Microbiota-dependent inflammation promotes metabolic disorder via NF-κB-mediated inhibition of SREBP in Drosophila adipocytes

  2021cites this paper
• PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction

  2021cites this paper
• Distinct Responses of Thitarodes xiaojinensis β-1,3-Glucan Recognition Protein-1 and Immulectin-8 to Ophiocordyceps sinensis and Cordyceps militaris Infection

  2021cites this paper
• Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth.

  2021cites this paper
• Coevolution of Molluscs and Their Microbes

  2021cites this paper
• Disparate regulation of IMD signaling drives sex differences in infection pathology in Drosophila melanogaster

  2021cites this paper
• Protein Phosphatase 4 Negatively Regulates the Immune Deficiency-NF-κB Pathway during the Drosophila Immune Response

  2021cites this paper
• Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation

  2021cites this paper
• Current understanding and perspectives on the potential mechanisms of immune priming in beetles.

  2021cites this paper
• Bacteria-derived peptidoglycan triggers an NF-κB dependent response in Drosophila gustatory neurons

  2021cites this paper
• Bacterial Nucleoside Catabolism Controls Quorum Sensing and Commensal-to-Pathogen Transition in the Drosophila Gut.

  2020cites this paper
• Gut microbiota is essential in PGRP-LA regulated immune protection against Plasmodium berghei infection

  2020cites this paper
• Gut Bacterial Species Distinctively Impact Host Purine Metabolites during Aging in Drosophila

  2020cites this paper
• Sepsis roadmap: What we know, what we learned, and where we are going.

  2020cites this paper
• How commensal microbes shape the physiology of Drosophila melanogaster.

  2020cites this paper
• Gut bacteria-derived peptidoglycan induces a metabolic syndrome-like phenotype via NF-κB-dependent insulin/PI3K signaling reduction in Drosophila renal system

  2020cites this paper
• Disparate regulation of imd drives sex differences in infection tolerance in Drosophila melanogaster

  2020cites this paper
• The mode of expression divergence in Drosophila fat body is infection-specific

  2020cites this paper
• Beyond Host Defense: Deregulation of Drosophila Immunity and Age-Dependent Neurodegeneration

  2020cites this paper
• Physiological and Pathological Regulation of Peripheral Metabolism by Gut-Peptide Hormones in Drosophila

  2020cites this paper
• General overview on the role of Peptidoglycan Recognition Proteins in insect immunity.

  2020cites this paper
• Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression

  2020cites this paper
• Receptors Mediating Host-Microbiota Communication in the Metaorganism: The Invertebrate Perspective

  2020cites this paper
• How Bacteria Impact Host Nervous System and Behaviors: Lessons from Flies and Worms.

  2020cites this paper
• Drosophila Aversive Behavior toward Erwinia carotovora carotovora Is Mediated by Bitter Neurons and Leukokinin

  2020cites this paper
• Vibrio-bivalve interactions in health and disease.

  2020cites this paper
• Microbiomes as modulators of Drosophila melanogaster homeostasis and disease.

  2020cites this paper
• JNK-dependent intestinal barrier failure disrupts host–microbe homeostasis during tumorigenesis

  2020cites this paper
• The Drosophila gut: A gatekeeper and coordinator of organism fitness and physiology

  2020influential citation
• Regulation of the Drosophila Imd pathway by signaling amyloids.

  2019cites this paper
• Ingestion of killed bacteria activates antimicrobial peptide genes in Drosophila melanogaster and protects flies from septic infection

  2019cites this paper
• Immunometabolism: Insights from the Drosophila model

  2019cites this paper
• [Muramyldipeptide - based compounds in current medicine: focus on glucosaminylmuramyl dipeptide].

  2019cites this paper
• A role of peptidoglycan recognition proteins in regulating innate immune response

  2019cites this paper
• Peptidoglycan-dependent NF-κB activation in a small subset of brain octopaminergic neurons controls female oviposition

  2019cites this paper
• Nephrocytes Remove Microbiota-Derived Peptidoglycan from Systemic Circulation to Maintain Immune Homeostasis.

  2019influential citation
• Listening to your gut: immune challenge to the gut sensitizes body wall nociception in the caterpillar Manduca sexta

  2019cites this paper
• The Intestine of Drosophila melanogaster: An Emerging Versatile Model System to Study Intestinal Epithelial Homeostasis and Host-Microbial Interactions in Humans

  2019cites this paper
• JNK-dependent intestinal barrier failure disrupts host-microbe homeostasis during tumorigenesis

  2019cites this paper
• Pattern recognition receptors in Drosophila immune responses.

  2019cites this paper
• The Taiman Transcriptional Coactivator Engages Toll Signals to Promote Apoptosis and Intertissue Invasion in Drosophila.

  2019cites this paper
• Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila.

  2019cites this paper
• Microbial Communities in Different Developmental Stages of the Oriental Fruit Fly, Bactrocera dorsalis, Are Associated with Differentially Expressed Peptidoglycan Recognition Protein-Encoding Genes

  2019cites this paper
• Weevil pgrp-lb prevents endosymbiont TCT dissemination and chronic host systemic immune activation

  2019cites this paper
• PGRP‐LB homolog acts as a negative modulator of immunity in maintaining the gut‐microbe symbiosis of red palm weevil, Rhynchophorus ferrugineus Olivier

  2018cites this paper
• The hydrolase LpqI primes mycobacterial peptidoglycan recycling

  2018cites this paper
• Mycobacteria recycle their peptidoglycan via a novel pathway which influences antimicrobial resistance and limits proliferation in macrophages

  2018cites this paper
• Microbiota‐Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan

  2018cites this paper
• Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster

  2018cites this paper
• A Balancing Act: PGRPs Preserve and Protect.

  2018cites this paper