Mucin Production and Hydration Responses to Mucopurulent Materials in Normal versus Cystic Fibrosis Airway Epithelia

No abstract is available for this paper.

• Publication year

  2017

• Venue

  American Journal of Respiratory and Critical Care Medicine

• Publication date

  2017-11-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1164/rccm.201706-1139OCPMID 29099608PMCID PMC5821906
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Airway Mucin Concentration as a Marker of Chronic Bronchitis

  2017cited by this paper
• Under Pressure: Reduced Cerebral Perfusion as a Risk Factor for Postoperative Delirium in Lung Transplant Recipients.

  2016cited by this paper
• Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype.

  2016cited by this paper
• Baseline Goblet Cell Mucin Secretion in the Airways Exceeds Stimulated Secretion over Extended Time Periods, and Is Sensitive to Shear Stress and Intracellular Mucin Stores

  2015cited by this paper
• The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis.

  2015cited by this paper
• Chronic Bronchitis and Current Smoking Are Associated with More Goblet Cells in Moderate to Severe COPD and Smokers without Airflow Obstruction

  2015cited by this paper
• Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure.

  2014cited by this paper
• Muc5b is required for airway defence

  2013cited by this paper
• Inflammation promotes airway epithelial ATP release via calcium-dependent vesicular pathways.

  2013cited by this paper
• Studying mucin secretion from human bronchial epithelial cell primary cultures.

  2012cited by this paper
• Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways

  2012cited by this paper
• Serine Proteases Degrade Airway Mucins in Cystic Fibrosis

  2011cited by this paper
• Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells

  2010cited by this paper
• Airway Epithelial Inflammation-induced Endoplasmic Reticulum Ca2+ Store Expansion Is Mediated by X-box Binding Protein-1*

  2009influential reference
• Physical and transport properties of sputum from children with idiopathic bronchiectasis.

  2008cited by this paper
• Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?

  2008cited by this paper
• Proteases and cystic fibrosis.

  2008cited by this paper
• Munc13‐2−/− baseline secretion defect reveals source of oligomeric mucins in mouse airways

  2008cited by this paper
• Extracellular purines are biomarkers of neutrophilic airway inflammation

  2008influential reference
• Regulation of airway goblet cell mucin secretion by tyrosine phosphorylation signaling pathways.

  2007cited by this paper
• Calcium signaling in human airway goblet cells following purinergic activation.

  2007cited by this paper
• Sputum biomarkers of inflammation in cystic fibrosis lung disease.

  2007cited by this paper
• Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients.

  2007cited by this paper
• Soluble Mediators, Not Cilia, Determine Airway Surface Liquid Volume in Normal and Cystic Fibrosis Superficial Airway Epithelia

  2006cited by this paper
• Regulation of mucin genes in chronic inflammatory airway diseases.

  2006cited by this paper
• Respiratory tract mucin genes and mucin glycoproteins in health and disease.

  2006cited by this paper
• Chronic Airway Infection/Inflammation Induces a Ca2+i-dependent Hyperinflammatory Response in Human Cystic Fibrosis Airway Epithelia*

  2005cited by this paper
• Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice

  2004cited by this paper
• Reevaluating gel-forming mucins' roles in cystic fibrosis lung disease.

  2004cited by this paper
• Interleukin-1β–Induced Mucin Production in Human Airway Epithelium Is Mediated by Cyclooxygenase-2, Prostaglandin E2 Receptors, and Cyclic AMP-Protein Kinase A Signaling

  2004cited by this paper
• Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling.

  2004cited by this paper
• Mucins and their O-Glycans from human bronchial epithelial cell cultures.

  2004cited by this paper
• New Monoclonal Antibodies to Non-Glycosylated Domains of the Secreted Mucins MUC5B and MUC7

  2003cited by this paper
• Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist.

  2002cited by this paper
• Mucus clearance as a primary innate defense mechanism for mammalian airways.

  2002cited by this paper
• Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B.

  2002cited by this paper
• OVEREXPRESSION OF MUCIN GENES INDUCED BY INTERLEUKIN1-1β, TUMOR NECROSIS FACTOR-α, LIPOPOLYSACCHARIDE, AND NEUTROPHIL ELASTASE IS INHIBITED BY A RETINOIC ACID RECEPTOR α ANTAGONIST

  2002cited by this paper
• Regulation of Murine Airway Surface Liquid Volume by CFTR and Ca2+-activated Cl− Conductances

  2002cited by this paper
• Matrix metalloproteases in BAL fluid of patients with cystic fibrosis and their modulation by treatment with dornase alpha

  2002cited by this paper
• Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species.

  2002cited by this paper
• Polarized Signaling via Purinoceptors in Normal and Cystic Fibrosis Airway Epithelia

  2001cited by this paper
• Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro.

  1999cited by this paper
• Respiratory mucins: identification of core proteins and glycoforms.

  1996cited by this paper
• P2u purinoceptor regulation of mucin secretion in SPOC1 cells, a goblet cell line from the airways.

  1996cited by this paper
• Inflammatory cytokines in cystic fibrosis lungs.

  1995cited by this paper
• Airway goblet cells: responsive and adaptable front-line defenders.

  1994cited by this paper
• Pulmonary macrophages.

  1994cited by this paper
• The effect of neutrophil protenase enzymes on the release of mucus from feline and human airway cultures.

  1994cited by this paper
• Evidence for shared epitopes within the 'naked' protein domains of human mucus glycoproteins. A study performed by using polyclonal antibodies and electron microscopy.

  1991cited by this paper
• Proteinases of Pseudomonas aeruginosa evoke mucin release by tracheal epithelium.

  1984cited by this paper
• Replacement therapy of alpha 1-antitrypsin deficiency. Reversal of protease-antiprotease imbalance within the alveolar structures of PiZ subjects.

  1981cited by this paper
• STUDIES ON PULMONARY SECRETIONS. I. THE OVER-ALL CHEMICAL COMPOSITION OF PULMONARY SECRETIONS FROM PATIENTS WITH CYSTIC FIBROSIS, BRONCHIECTASIS, AND LARYNGECTOMY.

  1963cited by this paper

• Host- and microbial-mediated mucin degradation differentially shape Pseudomonas aeruginosa physiology and gene expression

  2025cites this paper
• Airway IL-1β is related to disease severity and mucociliary function in bronchiectasis

  2024cites this paper
• The epithelium takes the stage in asthma and inflammatory bowel diseases

  2024cites this paper
• Biological activities of gastropods secretions: snail and slug slime

  2023cites this paper
• Engineering in vitro models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials

  2023cites this paper
• Engineering in vitro models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials.

  2023cites this paper
• Club cell CREB regulates the goblet cell transcriptional network and pro-mucin effects of IL-1B

  2023cites this paper
• Cystic fibrosis airway inflammation enables elexacaftor/tezacaftor/ivacaftor-mediated rescue of N1303K CFTR mutation

  2023cites this paper
• Mucus and mucus flake composition and abundance reflect inflammatory and infection status in cystic fibrosis.

  2022cites this paper
• Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

  2022cites this paper
• Physiology and Pathophysiology of Human Airway Mucus.

  2022cites this paper
• Airway inflammation in patients with bronchiectasis

  2021cites this paper
• IRE1α Is a Therapeutic Target for Cystic Fibrosis Airway Inflammation

  2021influential citation
• Airway Epithelial Inflammation In Vitro Augments the Rescue of Mutant CFTR by Current CFTR Modulator Therapies

  2021influential citation
• Mucus, Microbiomes and Pulmonary Disease

  2021cites this paper
• Airway-On-A-Chip: Designs and Applications for Lung Repair and Disease

  2021cites this paper
• CFTR modulator response measurements in subjects with cystic fibrosis using 2D differentiated nasal epithelia converted into spheroids

  2021cites this paper
• Culture with apically applied healthy or disease sputum alters the airway surface liquid proteome and ion transport across human bronchial epithelial cells

  2021cites this paper
• Advancing Discovery of Snail Mucins Function and Application

  2021cites this paper
• Mucus Hypersecretion, Hyperconcentration and Chronic Bronchitis

  2021cites this paper
• Impact of Airway Inflammation on the Efficacy of CFTR Modulators

  2021cites this paper
• Running title: CFTR drug assay with airway organoids

  2021cites this paper
• Bronchial Mucus: Basic research and clinical application

  2020cites this paper
• Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways.

  2020cites this paper
• Membrane-bound mucins of the airway mucosal surfaces are densely decorated with keratan sulfate: revisiting their role in the Lung's innate defense.

  2020cites this paper
• Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus.

  2020cites this paper
• Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis

  2020cites this paper
• Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

  2019cites this paper
• Cystic Fibrosis: Emerging Understanding and Therapies.

  2019cites this paper
• Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia.

  2019cites this paper
• Muco‐Obstructive Lung Diseases

  2019cites this paper
• Revealing the molecular signaling pathways of mucus stasis in cystic fibrosis.

  2019cites this paper
• IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis.

  2019cites this paper
• Update in Cystic Fibrosis 2018.

  2019cites this paper
• Pediatric Pulmonology

  2019cites this paper
• Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis.

  2019cites this paper
• Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection

  2018cites this paper
• The cystic fibrosis airway milieu enhances rescue of F508del in a pre-clinical model

  2018cites this paper
• Mucopurulent Triggering of the Airway Epithelium. Implications in Health and Cystic Fibrosis.

  2018cites this paper
• Emerging Concepts and Therapies for Mucoobstructive Lung Disease

  2018cites this paper
• SPLUNC1 degradation by the cystic fibrosis mucosal environment drives airway surface liquid dehydration

  2018cites this paper