mcr-1−Harboring Salmonella enterica Serovar Typhimurium Sequence Type 34 in Pigs, China

We detected the mcr-1 gene in 21 (14.8%) Salmonella isolates from pigs at slaughter; 19 were serovar Typhimurium sequence type 34. The gene was located on IncHI2-like plasmids that also harbored IncF replicons and lacked a conjugative transfer region. These findings highlight the need to prevent further spread of colistin resistance in animals and humans.

• Publication year

  2017

• Venue

  Emerging Infectious Diseases

• Publication date

  2017-02-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3201/eid2302.161543PMID 28098547PMCID 5324782
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Multidrug-Resistant Escherichia coli in Bovine Animals, Europe

  2016cited by this paper
• Dissemination of the mcr-1 colistin resistance gene.

  2016cited by this paper
• Escherichia coli Harboring mcr-1 and blaCTX-M on a Novel IncF Plasmid: First Report of mcr-1 in the United States

  2016cited by this paper
• Detection of the plasmid-mediated mcr-1 gene conferring colistin resistance in human and food isolates of Salmonella enterica and Escherichia coli in England and Wales.

  2016cited by this paper
• Dissemination of the mcr-1 colistin resistance gene.

  2016cited by this paper
• MCR-1 in multidrug-resistant and copper-tolerant clinically relevant Salmonella 1,4,[5],12:i:- and S. Rissen clones in Portugal, 2011 to 2015.

  2016cited by this paper
• Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.

  2016cited by this paper
• Dissemination of the mcr-1 colistin resistance gene.

  2016cited by this paper
• Transferable resistance to colistin: a new but old threat.

  2016cited by this paper
• Polymorphism of genes encoding PmrAB in colistin-resistant strains of Escherichia coli and Salmonella enterica isolated from poultry and swine.

  2015cited by this paper
• The Molecular Epidemiological Characteristics and Genetic Diversity of Salmonella Typhimurium in Guangdong, China, 2007–2011

  2014cited by this paper
• Expansion of Salmonella enterica Serovar Typhimurium ST34 Clone Carrying Multiple Resistance Determinants in China

  2013cited by this paper
• Emergence of multidrug-resistant Salmonella enterica serotype 4,[5],12:i:- involving human cases in Canada: results from the Canadian Integrated Program on Antimicrobial Resistance Surveillance (CIPARS), 2003-10.

  2013cited by this paper
• Leakage of emerging clinically relevant multidrug-resistant Salmonella clones from pig farms.

  2011cited by this paper
• BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons

  2011cited by this paper
• The RAST Server: Rapid Annotations using Subsystems Technology

  2008influential reference
• Amplification of an invA gene sequence of Salmonella typhimurium by polymerase chain reaction as a specific method of detection of Salmonella.

  1992cited by this paper

• Genomic analysis of a multidrug-resistant monophasic Salmonella Typhimurium from Chinese beef harboring a novel mcr-1-bearing IncHI2-IncHI2A plasmid

  2026cites this paper
• Colistin resistance plasmids dually enhance bacterial virulence and antibiotic resistance via surface polysaccharide biosynthesis

  2025cites this paper
• Antibiotic susceptibility and genomic analysis of ciprofloxacin-resistant and ESBLs-producing Escherichia coli in vegetables and their irrigation water and growing soil.

  2024cites this paper
• Prevalence, antimicrobial resistance, and genomic characterization of Salmonella strains isolated in Hangzhou, China: a two-year study

  2024cites this paper
• Clonal spread of blaNDM-1-carrying Salmonella enterica serovar Typhimurium clone ST34 and wide spread of IncHI2/ST3-blaNDM-5 plasmid in China.

  2024cites this paper
• Prevalence and molecular characterization of mcr-1-positive foodborne ST34-Salmonella isolates in China.

  2023cites this paper
• A Review of Resistance to Polymyxins and Evolving Mobile Colistin Resistance Gene (mcr) among Pathogens of Clinical Significance

  2023cites this paper
• Mechanistic Insights of Colistin Resistance and Its Public Health Implications

  2023cites this paper
• Carriage and Transmission of mcr-1 in Salmonella Typhimurium and Its Monophasic 1,4,[5],12:i:- Variants from Diarrheal Outpatients: a 10-Year Genomic Epidemiology in Guangdong, Southern China

  2023cites this paper
• Genomic Characterization of mcr-1-Carrying Foodborne Salmonella enterica serovar Typhimurium and Identification of a Transferable Plasmid Carrying mcr-1, blaCTX-M-14, qnrS2, and oqxAB Genes From Ready-to-Eat Pork Product in China

  2022cites this paper
• The Occurrence and Genomic Characteristics of mcr-1-Harboring Salmonella from Retail Meats and Eggs in Qingdao, China

  2022cites this paper
• Insights into the effects of pulsed antimicrobials on chicken resistome and microbiota from fecal metagenomes

  2022cites this paper
• Global epidemiology, genetic environment, risk factors and therapeutic prospects of mcr genes: A current and emerging update

  2022influential citation
• Role of Horizontal Gene Transfer in the Dissemination of Antimicrobial Resistance in Food Animal Production

  2022cites this paper
• Conjugative transfer of mcr-1-bearing plasmid from Salmonella to Escherichia coli in vitro on chicken meat and in mouse gut.

  2022cites this paper
• Low Level of Colistin Resistance and mcr Genes Presence in Salmonella spp.: Evaluation of Isolates Collected between 2000 and 2020 from Animals and Environment

  2022cites this paper
• Genomic Characterization of Antimicrobial Resistance in Food Chain and Livestock-Associated Salmonella Species

  2021cites this paper
• First identification and Limited Dissemination of mcr-1 Colistin Resistance in Salmonella Isolates in Jiaxing.

  2021cites this paper
• Prevalence and transmission of mobilized colistin resistance (mcr-1) gene positive Escherichia coli in healthy rural residents in Shandong province, China.

  2021cites this paper
• Global distribution of plasmid‐mediated colistin resistance mcr gene in Salmonella: A systematic review

  2021cites this paper
• Reducing the Risk of Transmission of Critical Antimicrobial Resistance Determinants From Contaminated Pork Products to Humans in South-East Asia

  2021cites this paper
• Occurrence of mcr-mediated colistin resistance in Salmonella clinical isolates in Thailand

  2021cites this paper
• Vertical and horizontal distributions of clinical antibiotic resistance genes and bacterial communities in Danjiangkou Reservoir, China

  2021cites this paper
• Mobile Colistin Resistance Gene mcr-1 Detected on an IncI2 Plasmid in Salmonella Typhimurium Sequence Type 19 from a Healthy Pig in South Korea

  2021cites this paper
• Prevalence, genomic characteristics, and transmission dynamics of mcr-1-positive Salmonella enterica Typhimurium from patients with infectious diarrhea.

  2021cites this paper
• Emergence of a Salmonella enterica serovar Typhimurium ST34 isolate, CFSA629, carrying a novel mcr-1.19 variant cultured from egg in China.

  2021cites this paper
• Co-selection may explain the unexpectedly high prevalence of plasmid-mediated colistin resistance gene mcr-1 in a Chinese broiler farm

  2020cites this paper
• Emerging colistin resistance in Salmonella enterica serovar Newport isolates from human infections

  2020cites this paper
• Molecular characteristics of extended-spectrum β-lactamase/AmpC-producing Salmonella enterica serovar Virchow isolated from food-producing animals during 2010-2017 in South Korea.

  2020cites this paper
• Carriage of Distinct mcr‐1‐Harboring Plasmids by Unusual Serotypes of Salmonella

  2020cites this paper
• Genomic Characterization of mcr-1-carrying Salmonella enterica Serovar 4,[5],12:i:- ST 34 Clone Isolated From Pigs in China

  2020influential citation
• Low Prevalence of mcr-1 Among Clinical Enterobacteriaceae Isolates and Co-transfer of mcr-1 and blaNDM-1 from Separate Donors

  2020cites this paper
• A Multidrug-resistant Monophasic Salmonella Typhimurium Co-harboring mcr-1, fosA3, blaCTX-M-14 in a Transferable IncHI2 Plasmid from a Healthy Catering Worker in China

  2020cites this paper
• Plasmid Dynamics of mcr-1-Positive Salmonella spp. in a General Hospital in China

  2020influential citation
• Prevalence and antimicrobial resistance of Salmonellaisolates from goose farms in Northeast China.

  2020cites this paper
• Molecular diversity and antibiotic resistance gene profile of Salmonella enterica serovars isolated from humans and food animals in Lagos, Nigeria.

  2019cites this paper
• Development and Validation of a Clinical Laboratory Improvement Amendments-Compliant Multiplex Real-Time PCR Assay for Detection of mcr Genes.

  2019cites this paper
• Epidemiologic and genomic insights on mcr-1-harbouring Salmonella from diarrhoeal outpatients in Shanghai, China, 2006–2016

  2019influential citation
• Plasmid-Mediated Colistin Resistance in Salmonella enterica: A Review

  2019cites this paper
• Non-typhoidal Salmonella in the Pig Production Chain: A Comprehensive Analysis of Its Impact on Human Health

  2019cites this paper
• Detection of mcr-Mediated Colistin Resistance in Escherichia coli Isolates from Pigs in Small-Scale Farms in Cambodia

  2019cites this paper
• Characterization of Highly Prevalent Plasmids Coharboring mcr-1, oqxAB, and blaCTX-M and Plasmids Harboring oqxAB and blaCTX-M in Escherichia coli Isolates from Food-Producing Animals in China

  2019cites this paper
• MDR Salmonella enterica serovar Typhimurium ST34 carrying mcr-1 isolated from cases of bloodstream and intestinal infection in children in China.

  2019cites this paper
• Using Colistin as a Trojan Horse: Inactivation of Gram-Negative Bacteria with Chlorophyllin

  2019cites this paper
• Emergence and Dissemination of mcr-Carrying Clinically Relevant Salmonella Typhimurium Monophasic Clone ST34

  2019influential citation
• First detection of the plasmid-mediated colistin resistance gene mcr-1 in virulent Vibrio parahaemolyticus.

  2019cites this paper
• Antibiotic Resistance Profiles of Salmonella Recovered From Finishing Pigs and Slaughter Facilities in Henan, China

  2019cites this paper
• Multidrug- and colistin-resistant Salmonella enterica 4,[5],12:i:- sequence type 34 carrying the mcr-3.1 gene on the IncHI2 plasmid recovered from a human.

  2019cites this paper
• Co-Occurrence of mcr-1 and qnrS1 on an IncHI2 Plasmid in Clinical Isolates of Salmonella Typhimurium in Spain

  2019influential citation
• The rise and spread of mcr plasmid-mediated polymyxin resistance

  2019cites this paper
• Current insights on high priority antibiotic-resistant Salmonella enterica in food and foodstuffs: a review

  2019cites this paper
• MCR-1-producing Salmonella Typhimurium ST34 links animal foods to human community infections

  2019cites this paper
• Complete Genomic Analysis of a Salmonella enterica Serovar Typhimurium Isolate Cultured From Ready-to-Eat Pork in China Carrying One Large Plasmid Containing mcr-1

  2018cites this paper
• Prevalence and molecular characteristics of mcr-1 gene in Salmonella typhimurium in a tertiary hospital of Zhejiang Province

  2018influential citation
• Clonal Spread of Escherichia coli ST93 Carrying mcr-1-Harboring IncN1-IncHI2/ST3 Plasmid Among Companion Animals, China

  2018cites this paper
• Characterization of extended-spectrum β-lactamase-producing Escherichia coli harboring mcr-1 and toxin genes from human fecal samples from China.

  2018cites this paper
• Emergence of a novel mobile colistin resistance gene, mcr-8, in NDM-producing Klebsiella pneumoniae

  2018cites this paper
• Hospitalized Patient as Source of Aspergillus fumigatus, 2015

  2018cites this paper
• Complete genetic analysis of a Salmonella enterica serovar Indiana isolate accompanying four plasmids carrying mcr-1, ESBL and other resistance genes in China.

  2017cites this paper
• Distinct mechanisms of acquisition of mcr-1 –bearing plasmid by Salmonella strains recovered from animals and food samples

  2017cites this paper
• Plasmid-mediated colistin resistance in animals: current status and future directions

  2017cites this paper