Mangiferin protects rat myocardial tissue against cyclophosphamide induced cardiotoxicity

Background Mangiferin is a highly potent antioxidant present in mango leaves which is utilized for therapeutic purposes. Objective The present study was undertaken to evaluate the cardioprotective effect of mangiferin against cyclophosphamide induced cardiotoxicity. Materials and methods Rats were treated with 100 mg/kg of mangiferin in alone and interactive groups for 10 days. Apart from normal and mangiferin control groups, all the groups were subjected to cyclophosphamide (200 mg/kg, i.p.) toxicity on Day 1 and effects of different treatments were analyzed by changes in serum biomarkers, tissue antioxidant levels, electrocardiographic parameters, lipid profile and histopathological evaluation. Results Mangiferin treated group showed decrease in serum biomarker enzyme levels and increase in tissue antioxidant levels. Compared to cyclophosphamide control group, mangiferin treated animals showed improvement in lipid profile, electrocardiographic parameters, histological score and mortality. Conclusion The present findings clearly suggest the protective role of mangiferin as a powerful antioxidant preventing cardiotoxicity caused by cyclophosphamide.

• Publication year

  2017

• Venue

  Journal of Ayurveda and Integrative Medicine

• Publication date

  2017-04-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.jaim.2017.04.006PMID 28610894PMCID 5496998
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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