A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Archives of Neurology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1001/ARCHNEUR.62.1.74PMID 15642852
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pattern of brain destruction in Parkinson's and Alzheimer's diseases

  2005cited by this paper
• Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract.

  2003cited by this paper
• Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain.

  2003cited by this paper
• Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

  2003cited by this paper
• NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits

  2003cited by this paper
• The Cast of Molecular Characters in Parkinson's Disease

  2003cited by this paper
• Distinct Retinoid Metabolic Functions for Alcohol Dehydrogenase Genes Adh1 and Adh4 in Protection against Vitamin A Toxicity or Deficiency Revealed in Double Null Mutant Mice*

  2002cited by this paper
• Alcohol dehydrogenase polymorphism and Parkinson's disease.

  2001cited by this paper
• Function, expression and polymorphism of human alcohol dehydrogenase 3/glutathionedependent formaldehyde dehydrogenase

  2001cited by this paper
• Alcohol dehydrogenase alleles in Parkinson's disease

  2000cited by this paper
• Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3.

  1999cited by this paper
• Diagnostic criteria for Parkinson disease.

  1999cited by this paper
• Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family.

  1999cited by this paper
• Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism.

  1999cited by this paper
• Parkinson disease in twins: an etiologic study.

  1999cited by this paper
• Alcohol dehydrogenase as a critical mediator of retinoic acid synthesis from vitamin A in the mouse embryo.

  1998cited by this paper
• Localization of cellular retinoid-binding proteins suggests specific roles for retinoids in the adult central nervous system.

  1994cited by this paper
• Parkinson's Disease Society Brain Bank, London: overview and research.

  1993cited by this paper
• Parkinson's disease: a case-control study of occupational and environmental risk factors.

  1990cited by this paper

• Association between alcohol consumption and mortality in Parkinson’s disease

  2025cites this paper
• Exploring GBA1 gene in Parkinson's disease: Prevalence and variant spectrum from Asia minor

  2025cites this paper
• An alcohol dehydrogenase 7 gene polymorphism associates with both acute and chronic pain in sickle cell disease.

  2023cites this paper
• Large-scale rare variant burden testing in Parkinson's disease.

  2023cites this paper
• Large-scale Rare Variant Burden Testing in Parkinson's Disease Identifies Novel Associations with Genes Involved in Neuro-inflammation

  2022cites this paper
• Whole Exome Sequencing Study in Isolated South-Eastern Moravia (Czechia) Population Indicates Heterogenous Genetic Background for Parkinsonism Development

  2022cites this paper
• High-Throughput Sequencing Haplotype Analysis Indicates in LRRK2 Gene a Potential Risk Factor for Endemic Parkinsonism in Southeastern Moravia, Czech Republic

  2022cites this paper
• Clinical Trials In Parkinson's Disease

  2021cites this paper
• The Role of Alcohol Dehydrogenase in Drug Metabolism: Beyond Ethanol Oxidation

  2021cites this paper
• Genetic Models of Parkinson’s

  2020cites this paper
• Investigation on Intestinal Proteins and Drug Metabolizing Enzymes in Simulated Microgravity Rats by a Proteomics Method

  2020cites this paper
• Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson’s Disease and Potential Therapeutic Role of 5’ Untranslated Region-Directed Small Molecules

  2020cites this paper
• Alcohol Use Disorder, Neurodegeneration, Alzheimer’s and Parkinson’s Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity

  2020cites this paper
• Investigating early functional alteration in a human iPSC-based model of Parkinson’s Disease

  2019cites this paper
• Alcohol Dehydrogenase 1B Suppresses β-Amyloid-Induced Neuron Apoptosis

  2019cites this paper
• No genetic evidence for involvement of alcohol dehydrogenase genes in risk for Parkinson’s disease

  2019cites this paper
• Human alcohol dehydrogenase 1 is an acceptor protein for polyADP-ribosylation.

  2019cites this paper
• A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort

  2019cites this paper
• Association between the missense alcohol dehydrogenase rs1229984T variant with the risk for Parkinson’s disease in women

  2018cites this paper
• Alcohol consumption and risk for Parkinson’s disease: a systematic review and meta-analysis

  2018cites this paper
• Parkinson’s Disease: Biomarkers, Treatment, and Risk Factors

  2018cites this paper
• An investigation into the genetic architecture of multiple system atrophy and familial Parkinson's disease

  2017cites this paper
• Association Between the rs1229984 Polymorphism in the Alcohol Dehydrogenase 1B Gene and Risk for Restless Legs Syndrome

  2017cites this paper
• Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver

  2017cites this paper
• Gene Set Analysis of SNP Data from Genome‐wide Association Studies

  2017cites this paper
• Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease

  2015cites this paper
• Multiple system atrophy: the application of genetics in understanding etiology

  2015cites this paper
• Aldehyde dehydrogenase 2 genetic variations may increase susceptibility to Parkinson's disease in Han Chinese population.

  2015cites this paper
• Genomic and pharmacogenomic biomarkers of Parkinson's disease.

  2014cites this paper
• Rare ADH variant constellations are specific for alcohol dependence.

  2013influential citation
• Partial trisomy 4q associated with young-onset dopa-responsive parkinsonism.

  2012cites this paper
• Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease.

  2012cites this paper
• International Evaluation of Research and Doctoral Training at the University of Helsinki 2005-2010: RC-Specific Evaluation of MNRP - Research Program of Molecular Neurology

  2012cites this paper
• The Reference Human Genome Demonstrates High Risk of Type 1 Diabetes and Other Disorders

  2011cites this paper
• Genes Involved in Parkinson's Disease - Focus on Mitochondrial and Detoxifying Enzymes

  2011cites this paper
• Alcohol Dehydrogenase 2 Genotype and Risk for Migraine

  2010cites this paper
• Alcohol drinking and risk of Parkinson's disease: a case-control study in Japan

  2010cites this paper
• Phenotype prediction of deleterious nonsynonymous single nucleotide polymorphisms in human alcohol metabolism-related genes: a bioinformatics study.

  2010cites this paper
• A novel X‐linked four‐repeat tauopathy with Parkinsonism and spasticity

  2010cites this paper
• Molecular Biology of Parkinson's Disease

  2009cites this paper
• Generation of dopamine neurons in vivo and from embryonic stem cells in vitro

  2009cites this paper
• Ludwig Institute for Cancer Research and Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden GENERATION OF DOPAMINE NEURONS IN VIVO AND FROM EMBRYONIC STEM CELLS IN VITRO

  2009cites this paper
• Mutations in human monoamine‐related neurotransmitter pathway genes

  2008cites this paper
• On the roles of genes in Parkinsons disease

  2008cites this paper
• ADH7 variation modulates extraversion and conscientiousness in substance‐dependent subjects

  2008cites this paper
• Polymorphism in ADH and MTHFR genes in oral squamous cell carcinoma of Indians.

  2008cites this paper
• SPECT-aided diagnostics and genetic risk factors in Parkinson's disease

  2008cites this paper
• Genbank Parkinson-Krankheit Deutschland

  2007cites this paper
• High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract

  2007cites this paper
• Alcohol Dehydrogenase 2 Genotype and Allelic Variants Are Not Associated With the Risk for Essential Tremor

  2007cites this paper
• Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency

  2007cites this paper
• The ADH1C stop mutation in multiple system atrophy patients and healthy probands in the United Kingdom and Germany

  2006cites this paper
• Tardive blepharospasm beginning after withdrawal of veralipride

  2006cites this paper
• LRRK2 expression linked to dopamine‐innervated areas

  2006cites this paper
• Tissue- and species-specific expression patterns of class I, III, and IV Adh and Aldh1 mRNAs in rodent embryos

  2005cites this paper
• Gene Expression Profiling of Sporadic Parkinson's Disease Substantia Nigra Pars Compacta Reveals Impairment of Ubiquitin‐Proteasome Subunits, SKP1A, Aldehyde Dehydrogenase, and Chaperone HSC‐70

  2005cites this paper
• Factores genéticos involucrados en la susceptibilidad para desarrollar enfermedad de Parkinson

  2004cites this paper
• Methanolic Root Extract of Citrullus Colocynthis Ameliorate Parkinson's Disease in Experimental Animals

  year unknowncites this paper