Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  International Journal of Radiation Oncology, Biology, Physics

• Publication date

  1999-03-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1016/S0360-3016(98)00477-5PMID 10098443
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Single Dose of Thrombopoietin Shortly After Myelosuppressive Total Body Irradiation Prevents Pancytopenia in Mice by Promoting Short-Term Multilineage Spleen-Repopulating Cells at the Transient Expense of Bone Marrow–Repopulating Cells

  1998cited by this paper
• A single dose of thrombopoietin shortly after myelosuppressive total body irradiation prevents pancytopenia in mice by promoting short-term multilineage spleen-repopulating cells at the transient expense of bone marrow-repopulating cells.

  1998cited by this paper
• A single intravenous dose of murine megakaryocyte growth and development factor potently stimulates platelet production, challenging the necessity for daily administration.

  1998cited by this paper
• Multilineage hematopoietic recovery by a single injection of pegylated recombinant human megakaryocyte growth and development factor in myelosuppressed mice.

  1998cited by this paper
• Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+ CD38-) human bone marrow progenitor cells: distinct and key interactions with the ligands for c-kit and flt3, and inhibitory effects of TGF-beta and TNF-alpha.

  1997cited by this paper
• A prospective study of radiation therapy-associated thrombocytopenia.

  1997cited by this paper
• Recombinant human c-Mpl ligand (thrombopoietin) not only acts on megakaryocyte progenitors, but also on erythroid and multipotential progenitors in vitro.

  1997cited by this paper
• Simultaneous administration of TPO and G-CSF after cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platelet and red cell reconstitution, alleviates neutropenia, and promotes the recovery of immature bone marrow cells.

  1997cited by this paper
• Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer.

  1997cited by this paper
• A single injection of pegylated murine megakaryocyte growth and development factor (MGDF) into mice is sufficient to produce a profound stimulation of megakaryocyte frequency, size, and ploidization.

  1997cited by this paper
• Lack of efficacy of thrombopoietin and granulocyte colony-stimulating factor after high dose total-body irradiation and autologous stem cell or bone marrow transplantation in rhesus monkeys.

  1997cited by this paper
• Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer.

  1997cited by this paper
• The Efficacy of Single-Dose Administration of Thrombopoietin With Coadministration of Either Granulocyte/Macrophage or Granulocyte Colony-Stimulating Factor in Myelosuppressed Rhesus Monkeys

  1997cited by this paper
• The efficacy of single-dose administration of thrombopoietin with coadministration of either granulocyte/macrophage or granulocyte colony-stimulating factor in myelosuppressed rhesus monkeys.

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• Thrombopoietin: the primary regulator of megakaryocytopoiesis and thrombopoiesis.

  1997cited by this paper
• Prevention of thrombocytopenia by thrombopoietin in myelosuppressed rhesus monkeys accompanied by prominent erythropoietic stimulation and iron depletion.

  1997cited by this paper
• Radiotherapy-associated neutropenia and thrombocytopenia: analysis of risk factors and development of a predictive model.

  1997cited by this paper
• Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice.

  1996cited by this paper
• In Vivo Biological Effects of Various Forms of Thrombopoietin in a Murine Model of Transient Pancytopenia

  1996cited by this paper
• The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells.

  1996cited by this paper
• Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation.

  1996cited by this paper
• Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice.

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• In Vivo Effects of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor on Hematopoiesis in Normal Mice

  1996cited by this paper
• Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice.

  1996cited by this paper
• Recombinant Human Ligand for MPL, Megakaryocyte Growth and Development Factor (MGDF), Stimulates Thrombopoiesis in Vivo in Normal and Myelosuppressed Baboons

  1996cited by this paper
• Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer.

  1996cited by this paper
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  1996cited by this paper
• Combined effects of interleukin-3 and interleukin-11 on hematopoiesis in irradiated mice.

  1996cited by this paper
• Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation.

  1996cited by this paper
• Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin- primitive progenitor cells.

  1996cited by this paper
• Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3.

  1996cited by this paper
• Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia.

  1996cited by this paper
• Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice.

  1996cited by this paper
• Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin− primitive progenitor cells

  1996cited by this paper
• Modulation of megakaryocytopoiesis by thrombopoietin: the c-Mpl ligand.

  1995cited by this paper
• Chapter 6: Cell and cell system responses: Heterogeneity of radiation sensitivity of hemopoietic stem cell subsets

  1995cited by this paper
• Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice.

  1995cited by this paper
• Purification and characterization of thrombopoietin.

  1995cited by this paper
• Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy.

  1995cited by this paper
• Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice.

  1995cited by this paper
• Clinical Toxicity of Cytokines Used As Haemopoietic Growth Factors

  1995cited by this paper
• Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor.

  1995cited by this paper
• Secretion of cytokines (interleukins-1 alpha, -3, and -6 and granulocyte-macrophage colony-stimulating factor) by normal human bone marrow megakaryocytes.

  1995cited by this paper
• Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates.

  1995cited by this paper
• Interleukin-1 alpha administered after autologous transplantation: a phase I/II clinical trial.

  1994cited by this paper
• Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

  1994cited by this paper
• In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells.

  1994cited by this paper
• The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production.

  1994cited by this paper
• Cytokine production by primary bone marrow megakaryocytes.

  1994cited by this paper
• The clinical utility of granulocyte colony‐stimulating factor: Early achievements and future promise

  1994cited by this paper
• Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl.

  1994cited by this paper
• Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin.

  1994cited by this paper
• Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

  1994cited by this paper
• c-Mpl ligand is a humoral regulator of megakaryocytopoiesis

  1994cited by this paper
• Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

  1994cited by this paper
• [Transient thrombocytopenia after the administration of granulocyte colony-stimulating factor in a patient with acute agranulocytosis].

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  1993cited by this paper
• Effects of recombinant canine stem cell factor, a c-kit ligand, and recombinant granulocyte colony-stimulating factor on hematopoietic recovery after otherwise lethal total body irradiation.

  1993cited by this paper
• [Transient thrombocytopenia after the administration of granulocyte colony-stimulating factor in a patient with acute agranulocytosis].

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• Postirradiation treatment with granulocyte colony-stimulating factor and preirradiation WR-2721 administration synergize to enhance hemopoietic reconstitution and increase survival.

  1992cited by this paper
• Recombinant glycosylated human interleukin-6 accelerates peripheral blood platelet count recovery in radiation-induced bone marrow depression in baboons.

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  1992cited by this paper
• Administration of interleukin-6 stimulates multilineage hematopoiesis and accelerates recovery from radiation-induced hematopoietic depression.

  1991cited by this paper
• Therapeutic use of recombinant human G-CSF (rhG-CSF) in a canine model of sublethal and lethal whole-body irradiation.

  1990cited by this paper
• Effects of recombinant human granulocyte colony-stimulating factor on the hematologic recovery and survival of irradiated mice.

  1990cited by this paper
• Effects of recombinant human interleukin-3 in patients with normal hematopoiesis and in patients with bone marrow failure.

  1990cited by this paper
• Protective, restorative, and therapeutic properties of recombinant colony-stimulating factors.

  1989cited by this paper
• Postirradiation glucan administration enhances the radioprotective effects of WR-2721.

  1989cited by this paper
• Hematologic effects of recombinant human granulocyte colony-stimulating factor in patients with malignancy.

  1989cited by this paper
• Effect of recombinant human granulocyte colony-stimulating factor on hematopoiesis of normal dogs and on hematopoietic recovery after otherwise lethal total body irradiation.

  1989cited by this paper
• Cytokines in therapy of radiation injury.

  1988cited by this paper
• Recovery from severe hematopoietic suppression using recombinant human granulocyte-macrophage colony-stimulating factor.

  1988cited by this paper
• Effects of recombinant human granulocyte-colony stimulating factor on hematopoietic reconstitution after autologous bone marrow transplantation in primates.

  1987cited by this paper
• Radioprotection by interleukin. 1

  1987cited by this paper
• The total marrow mass of the mouse: A simplified method of measurement

  1984cited by this paper
• Self-renewal of hemopoietic stem cells during mixed colony formation in vitro.

  1981cited by this paper
• Characteristics of murine megakaryocytic colonies in vitro.

  1979cited by this paper
• Erythropoietin sensitivity as a differentiation marker in the hemopoietic system: Studies of three erythropoietic colony responses in culture

  1976cited by this paper

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  1998cites this paper