ABSORPTION AND RENAL EXCRETION OF THE TETRAETHYLAMMONIUM ION

1. TEA is quantitatively excreted by the kidneys in dogs and man after parenteral administration. In man 50% of an intravenous dose appears in the urine in 30 minutes, and 50% of an intramuscular dose in about 4 hours. 2. No delay in absorption from an intramuscular injection site was caused by incorporating the drug in a propylene glycol-beeswax mixture, but absorption was delayed after injection of the drug in Pitkin's menstruum. 3. The total excretion after oral administration in man is only 4 to 16% of the dose given. It is probable that poor absorption, rather than enteric or hepatic destruction, accounts for the low recovery. 4. The speed of excretion after intravenous injection in man, and the high extraction ratio obtained in the dog when the drug is infused into the renal artery, indicate that tubular excretion occurs in addition to glomerular filtration. 5. Since at high blood levels the extraction ratio falls below the glomerular filtration fraction, tubular reabsorption may also occur. 6. The drug should be used with caution in patients with severe renal damage.

• Publication year

  1947

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1947-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0022-3565(25)03097-6
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

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