Thyroid Hormone Therapy for the Cardiac Surgical Patient

Thyroid hormones (THs) are key regulators of metabolism. The thyroid gland produces both thyroxine (T4) and triiodothyronine (T3). T4 is the main product and is converted in the periphery via deiodination to T3 which is the main biologically active TH. The production of THs is regulated by thyrotrophin (TSH) in response to TSH releasing hormone (TRH). This, in turn, is regulated by a negative feedback mechanism related to serum levels of free T3 and T4 (fT3 and fT4). Binding of T3 to TH receptors (TR) followed by binding of T3-TR complex to thyroid response elements within TH responsive genes leads to changes in gene transcription. These effects of TH are present through a wide number of tissues and organ systems including the cardiovascular system.

• Publication year

  2012

• Venue

  Unknown venue

• Publication date

  2012-02-29

• Fields of study

  Medicine

• Identifiers
  DOI 10.5772/27684
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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