Novel quantitative tools for engineering analysis of hepatocyte cultures in bioartificial liver systems.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Biotechnology and Bioengineering

• Publication date

  2005-11-05

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1002/BIT.20586PMID 16180239
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Liver biology and pathobiology

  2006cited by this paper
• Health Inequalities and Why They Matter

  2004cited by this paper
• Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function

  2004cited by this paper
• Multiobjective optimization and multivariable control of the beer fermentation process with the use of evolutionary algorithms

  2004cited by this paper
• Metabolic engineering: advances in modeling and intervention in health and disease.

  2003cited by this paper
• Metabolic flux analysis of cultured hepatocytes exposed to plasma

  2003influential reference
• Cell choice for bioartificial livers.

  2003cited by this paper
• Branched-chain amino acids promote albumin synthesis in rat primary hepatocytes through the mTOR signal transduction system.

  2003influential reference
• Application of Multivariate Analysis to Optimize Function of Cultured Hepatocytes

  2003influential reference
• Engineering Liver Therapies for the Future

  2002cited by this paper
• General statistics of stochastic process of gene expression in eukaryotic cells.

  2002cited by this paper
• Critical issues in bioartificial liver development

  2002cited by this paper
• Uncertainty considerations for describing complex reaction systems

  2002cited by this paper
• Generalized Homotopy Approach to Multiobjective Optimization

  2001cited by this paper
• Streptogramin- and tetracycline-responsive dual regulated expression of p27(Kip1) sense and antisense enables positive and negative growth control of Chinese hamster ovary cells.

  2001cited by this paper
• Design of flexible reduced kinetic mechanisms

  2001cited by this paper
• Stem cell bioengineering.

  2001cited by this paper
• 13C metabolic flux analysis.

  2001cited by this paper
• Intrahepatic amino acid and glucose metabolism in a D‐galactosamine–induced rat liver failure model

  2001cited by this paper
• Optimization of isoamyl acetate production by using immobilized lipase from Mucor miehei by response surface methodology.

  2000cited by this paper
• Engineering of coordinated up- and down-regulation of two glycosyltransferases of the O-glycosylation pathway in Chinese hamster ovary (CHO) cells.

  2000cited by this paper
• Biochemical and Molecular Action of Nutrients Leucine Stimulates Translation Initiation in Skeletal Muscle of Postabsorptive Rats via a Rapamycin-Sensitive Pathway

  2000cited by this paper
• Amino Acid Supplementation Improves Cell-Specific Functions of the Rat Hepatocytes Exposed to Human Plasma

  2000cited by this paper
• Metabolic flux analysis of postburn hepatic hypermetabolism.

  2000cited by this paper
• Metabolic Flux Analysis: A Powerful Tool for Monitoring Tissue Function

  1999cited by this paper
• Cutaneous burn injury alters relative tricarboxylic acid cycle fluxes in rat liver.

  1999cited by this paper
• Bioreaction network topology and metabolic flux ratio analysis by biosynthetic fractional 13C labeling and two-dimensional NMR spectroscopy.

  1999cited by this paper
• Chinese hamster ovary cells with constitutively expressed sialidase antisense RNA produce recombinant dnase in batch culture with increased sialic acid

  1998cited by this paper
• Last chance to stop and think on risks of xenotransplants

  1998cited by this paper
• Bidirectional modulation of insulin action by amino acids.

  1998cited by this paper
• Normal-Boundary Intersection: A New Method for Generating the Pareto Surface in Nonlinear Multicriteria Optimization Problems

  1998cited by this paper
• Translational and pretranslational regulation of protein synthesis by amino acid availability in primary cultures of rat hepatocytes.

  1996cited by this paper
• Effect of amino acid limitation on the expression of 19 genes in rat hepatoma cells

  1994influential reference
• Proline‐mediated enhancement of hepatocyte function in a collagen gel sandwich culture configuration

  1993cited by this paper
• The importance of proline on long‐term hepatocyte function in a collagen gel sandwich configuration: Regulation of protein secretion

  1992cited by this paper
• Mechanism of inhibition of peptide chain initiation by amino acid deprivation in perfused rat liver. Regulation involving inhibition of eukaryotic initiation factor 2 alpha phosphatase activity.

  1991cited by this paper
• Effect of amino acid deprivation on initiation of protein synthesis in rat hepatocytes.

  1989cited by this paper
• Stochastic programming

  1989cited by this paper
• Regulation of albumin mRNA in H4 rat hepatoma cells by the availability of essential amino acids.

  1988cited by this paper
• Stochastic Programming

  1986cited by this paper
• The Liver: Biology and Pathobiology

  1983cited by this paper
• The role of amino acids in the regulation of protein synthesis in perfused rat liver. II. Effects of amino acid deficiency on peptide chain initiation, polysomal aggregation, and distribution of albumin mRNA.

  1982cited by this paper
• The role of amino acids in the regulation of protein synthesis in perfused rat liver. I. Reduction in rates of synthesis resulting from amino acid deprivation and recovery during flow-through perfusion.

  1982cited by this paper
• Effects of amino acids, ammonia and leupeptin on protein synthesis and degradation in isolated rat hepatocytes.

  1978cited by this paper
• Integrated System Identification and Optimization

  1973cited by this paper
• Effects of hypophysectomy on amino acid metabolism and gluconeogenesis in the perfused rat liver.

  1973cited by this paper
• Multi-Factor Experimental Designs for Exploring Response Surfaces

  1957cited by this paper

• Influence of oxygen uptake through the liver surface on the metabolism of ex vivo perfused liver during hypoxia.

  2023cites this paper
• Mathematical modeling of the metabolic activity of an isolated perfused rat liver under reduced oxygenation of the perfusion medium

  2018cites this paper
• Artificial Liver Bioreactor Design

  2016cites this paper
• Stoichiometric Modeling of Oxygen Transportation through the Surface of Isolated Perfused Rat Liver

  2016cites this paper
• “Big Data and Dynamics”—The Mathematical Toolkit Towards Personalized Medicine

  2016cites this paper
• CREPE: Mathematical Model for Crosstalking of Endothelial Cells and Hepatocyte Metabolism

  2014cites this paper
• Metabolic flux ratio analysis and multi-objective optimization revealed a globally conserved and coordinated metabolic response of E. coli to paraquat-induced oxidative stress.

  2013cites this paper
• Stoichiometry Based Steady-State Hepatic Flux Analysis: Computational and Experimental Aspects

  2012cites this paper
• Advanced stoichiometric analysis of metabolic networks of mammalian systems.

  2011cites this paper
• Metabolic Profiling Based Quantitative Evaluation of Hepatocellular Metabolism in Presence of Adipocyte Derived Extracellular Matrix

  2011cites this paper
• Bioinformatics analysis of control mechanisms of burn and sepsis induced inflammatory response

  2011influential citation
• Multiscale Integration of Toxicokinetic and Toxicodynamic Processes: From Cell and Tissue to Organ and “Whole Body” Models

  2011cites this paper
• Pathway analysis of liver metabolism under stressed condition.

  2011cites this paper
• Analysis of Amino Acid Supplementation Effects on Hepatocyte Cultures Using Flux Balance Analysis

  2011cites this paper
• Design and analysis of amino acid supplementation in hepatocyte culture using in vitro experiment and mathematical modeling

  2010influential citation
• Adipocyte‐derived basement membrane extract with biological activity: applications in hepatocyte functional augmentation in vitro

  2010cites this paper
• Effects of Triadimefon on the Metabolism of Cultured Hepatocytes

  2010cites this paper
• Effects of amino acid transport limitations on cultured hepatocytes.

  2010cites this paper
• Author ' s personal copy Transcriptional and metabolic fl ux pro fi ling of triadimefon effects on cultured hepatocytes

  2010cites this paper
• A Rational Design Approach for Amino Acid Supplementation in Hepatocyte Culture

  2009cites this paper
• Multiobjective flux balancing using the NISE method for metabolic network analysis

  2009cites this paper
• A rational design approach for amino acid supplementation in hepatocyte culture

  2009influential citation
• A unified multiscale field/network/agent based modeling framework for human and ecological health risk analysis

  2009cites this paper
• Stoichiometric modelling of cell metabolism.

  2008cites this paper
• HEMET: Mathematical model of biochemical pathways for simulation and prediction of HEpatocyte METabolism

  2008cites this paper
• Multiobjective Optimization in Bioinformatics and Computational Biology

  2007cites this paper
• Investigation of metabolic objectives in cultured hepatocytes

  2007cites this paper
• METABOLIC ENGINEERING OF EMBRYONIC STEM CELL DIFFERENTIATION INTO HEPATOCYTES By

  2007cites this paper
• Control of hepatic differentiation via cellular aggregation in an alginate microenvironment

  2007cites this paper
• Addressing the challenges of multiscale model management in systems biology

  2007cites this paper
• Minimal reaction sets and metabolic pathways for cultured hepatocytes

  2006cites this paper
• Sodium butyrate‐treated embryonic stem cells yield hepatocyte‐like cells expressing a glycolytic phenotype

  2006cites this paper
• Effects of Amino Acid Transport Limitations on Cultured Hepatocytes Biophysical Chemistry

  year unknowncites this paper