Osteoclast-like Giant Cell Tumor of Parotid Gland with a Carcinomatous Component: A Case Report

The giant cell tumor of the salivary gland is very rare, and 20 cases have been reported in the English-language literature. We report an additional case. A 57-year old man had noticed a mass in the right parotid area for several weeks. The diagnosis using aspiration cytology was a giant cell tumor possibly with a carcinomatous component. Superficial parotidectomy was carried out. The resected parotid gland contained a 1.8 cm-sized well-circumscribed brownish tumor. Histologically the tumor consisted of evenly distributed osteoclast-like giant cells, mononuclear cells and two small foci of a carcinomatous component. The osteoclast-like giant cells and mononuclear cells were positive for vimentin and CD68, and the carcinomatous component was positive for cytokeratin and epithelial membrane antigen. There was no metastatic lesion in the cervical lymph nodes. We believe this is the first case in Korea of an osteoclast-like giant cell tumor of the parotid gland.

• Publication year

  2012

• Venue

  The Korean Journal of Pathology

• Publication date

  2012-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.4132/KoreanJPathol.2012.46.3.297PMID 23110019PMCID 3479769
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Osteoclast-type giant cell tumor of minor salivary gland with mucin-rich salivary duct carcinoma: a case report of unusual histology with immunohistochemical analysis.

  2010cited by this paper
• WHO Classification of Tumours of the Digestive System

  2010cited by this paper
• Osteoclastlike giant cell tumor of the salivary gland.

  2009cited by this paper
• Pathologic Quiz Case: An Unusual Salivary Gland Tumor

  2009cited by this paper
• Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma?

  2009cited by this paper
• Osteoclast-Like Giant-Cell Tumor of the Parotid with Salivary Duct Carcinoma: Case Report and Cytologic, Histologic, and Immunohistochemical Findings

  2007cited by this paper
• Osteoclastomalike Giant Cell Tumor of the Parotid Gland

  2006cited by this paper
• Osteoclast-type Giant Cell Neoplasm of Salivary Gland. A Microdissection-based Comparative Genotyping Assay and Literature Review: Extraskeletal “Giant Cell Tumor of Bone” or Osteoclast-type Giant Cell “Carcinoma”?

  2004cited by this paper
• Pathologic quiz case: an unusual salivary gland tumor.

  2000cited by this paper
• Chromosome 11 aneuploidy detected by fluorescent in situ hybridization (FISH) in breast cancer: relation with progesterone receptor expression

  1999cited by this paper
• Fine Needle Aspiration Cytology of Osteoclast-like Giant Cell Tumor of the Liver: A Case Report.

  1999cited by this paper
• The spectrum of giant cells in tumours of the salivary glands: an analysis of 11 cases.

  1997cited by this paper
• Giant‐cell tumour of the salivary gland with associated carcinosarcoma

  1993cited by this paper
• A case of giant cell tumor of the parotid gland.

  1992cited by this paper
• Surgical Pathology of the Salivary Glands

  1992cited by this paper
• Fine‐needle aspiration cytology of osteoclastic giant‐cell tumor of the pancreas

  1990cited by this paper
• Osteoclast-type giant cell neoplasms of the parotid gland

  1988cited by this paper
• Carcinoma of the parotid gland with osteoclastlike giant cells. Immunohistochemical and ultrastructural observations.

  1985cited by this paper
• Giant cell tumor of major salivary glands: report of three cases, one occurring in association with a malignant mixed tumor.

  1984cited by this paper
• Ultrastructure of osteoclastoma-like giant cell tumor of thyroid.

  1978cited by this paper

• Giant cell tumour of the parotid gland: a rare, unusual entity

  2025cites this paper
• Genomic alteration in rare subtype of sarcomatoid salivary duct carcinoma.

  2021cites this paper
• Giant cell tumor of temporomandibular joint presenting as a parotid tumor: Challenges in the accurate subclassification of giant cell tumors in an unusual location

  2018cites this paper
• Osteoclast- like Giant Cell Tumour of the Salivary Gland: Case Report and Literature Review

  2016influential citation
• Osteoclast‐Like Giant Cell Tumor of the Parotid Gland: Report of a Case Diagnosed on Fine‐Needle Aspiration Cytology With Histological and Immunohistochemical Findings

  2016cites this paper
• Primary osteoclast-like giant cell tumor of parotid gland: A rare extraskeletal presentation with diagnostic challenges

  2016influential citation
• Tumeur à cellules géantes de type ostéoclastique de la parotide

  2014cites this paper
• Giant cell tumour of a temporomandibular joint presenting as a parotid mass: case report and analysis of the 19 cases in the literature.

  2014cites this paper
• [Osteoclast-type giant cell tumor of the parotid gland].

  2014cites this paper